2014
DOI: 10.1172/jci74701
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Working toward immune tolerance in lung transplantation

Abstract: Long-term allograft survival is a major challenge facing solid organ transplantation. Recent studies have shown a negative correlation between infiltration of memory T cells and allograft survival. Furthermore, blockade of leukocyte activation increases acceptance of transplanted organs, including heart, liver, and kidney. Lung allografts are associated with high rates of rejection, and therapies that increase acceptance of other transplanted organs have not translated into the lung. In this issue of the JCI, … Show more

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Cited by 9 publications
(7 citation statements)
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“…In this study, only 6% of the heart transplant recipients produced dnDSA, whereas 36% of lung transplant recipients produced dnDSA and both heart lung transplant recipients produced dnDSA. This supports the idea that the immunogenicity of lung transplantation is greater than heart transplantation due to the constant immune challenge associated with environmental exposure through respiration (Jiang & Nicolls, 2014). As the immunological risk of both heart and lung transplantation is currently assessed in the same way, both heart and lung transplant recipients were analysed together.…”
Section: Discussionmentioning
confidence: 55%
“…In this study, only 6% of the heart transplant recipients produced dnDSA, whereas 36% of lung transplant recipients produced dnDSA and both heart lung transplant recipients produced dnDSA. This supports the idea that the immunogenicity of lung transplantation is greater than heart transplantation due to the constant immune challenge associated with environmental exposure through respiration (Jiang & Nicolls, 2014). As the immunological risk of both heart and lung transplantation is currently assessed in the same way, both heart and lung transplant recipients were analysed together.…”
Section: Discussionmentioning
confidence: 55%
“…MEK inhibition may also suppress graft rejection after solid organ transplantation; however, several topics should be investigated. In contrast with bone marrow transplantation, host immunity is not ablated and immunological tolerance is unlikely after lung transplantation (19). The thymus is not ablated, and it is unknown how MEK inhibition modulates thymic function upon solid organ transplantation.…”
mentioning
confidence: 99%
“…They are either those of neonates or that of mature conventional and / or transgenic [19]. Like murine model for lung transplantation [20], and human CD3 trasngenic mice [21]. The present lapin model of oral mucosal tolerance, mucosal application of S. typhi bacterin induce low specific agglutination, specific IgM, Specific IgG as well as a mild rate of class switching from IgM to IgG.…”
Section: Resultsmentioning
confidence: 99%