Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation

Abstract

Objective: Acute rejection resulting from alloimmune responses is a major risk factor affecting patient survival following liver transplantation. Since interleukin (IL)-6 can mediate acute rejection, the association between IL-6 gene single nucleotide polymorphisms (SNPs) and incidence of acute rejection in liver transplant recipients was investigated. Methods: Patients who received liver transplant between January 2005 and December 2010 were typed for IL6-572C/G (rs1800796) polymorphisms using the snapshot technique. Association between genotype and acute rejection was analysed using the SNP Statistics website: http:// bioinfo.iconcologia.net/snpstats/start.htm. Allelic and genotypic distributions for rs1800796 were compared among 335 patients with or without acute rejection within the first 6 months following liver transplant. Results: Incidence of acute rejection was 11.94%. A heterozygous CG genotype for IL6-572C/G was associated with a lower acute rejection rate compared with homozygous CC or GG genotypes. Conclusion: IL6-572 CG genotype may be related to protection from acute rejection following liver transplant in Han Chinese patients.

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

“…As an important component of the cytokine network, IL6 is involved in a complex series of events that control pathological and physiological changes after liver transplantation. IL6 gene polymorphisms have been shown to be predictive factors for acute rejection after liver transplantation [10,35]. In our study population of Han Chinese patients with HCC, the donor IL6 rs2069852 AA genotype was found to be a predictor for an increased risk of HCC recurrence and a decreased survival rate, suggesting that IL6 has a tumor recurrence-promoting effect after liver transplantation.…”

“…Interleukin 6 (IL6) is a pleiotropic cytokine that has critical functions in the regulation of the biological responses of several target cells, including hepatocytes [9,10]. IL6 promotes liver regeneration and exerts hepatoprotective effects against Fas-mediated injury and toxic damage in the liver by activating the signal transducer and activator of transcription 3 (STAT3) and the mitogen-activated protein kinase (MAPK) signaling pathways [11].…”

Genetic Polymorphism of Interferon Regulatory Factor 5 (IRF5) Correlates with Allograft Acute Rejection of Liver Transplantation

“…The diagnoses of acute rejection were confirmed by liver biopsy and graded by Banff schema. Rejection occurred within 6 months was considered as acute rejection [33] , [34] .…”

Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration

“…Furthermore, it is considered to be a key regulator of human chronic inflammatory diseases (14). IL-6 is able to initiate various effects on the nervous system, vascular tissue, immune response and stress response, by modulating gene expression and cell survival, proliferation, and differentiation (15). Numerous studies have associated elevated serum levels of IL-6 with cardiovascular diseases, type 2 diabetes, rheumatoid arthritis, multiple sclerosis, Crohn's disease, and lymphatic, renal, bladder and colorectal cancers (13,16).…”