Rechallenge with Anti-EGFR Treatment in RAS/BRAF wt Metastatic Colorectal Cancer (mCRC) in Real Clinical Practice: Experience of the GITuD Group

Salgado Fernández, Mercedes; Reboredo López, Margarita; Covela Rúa, Marta; Candamio, Sonia; González-Villarroel, Paula; Sánchez-Cousido, Luis Felipe; Graña, Begoña; Carral-Maseda, Alberto; Cameselle-García, Soledad; Varela Pose, Vanesa; Gallardo-Martín, Maria Elena; Martínez-Lago, Nieves; ,

doi:10.1007/s11523-024-01062-z

Targ Oncol

2024

DOI: 10.1007/s11523-024-01062-z

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Rechallenge with Anti-EGFR Treatment in RAS/BRAF wt Metastatic Colorectal Cancer (mCRC) in Real Clinical Practice: Experience of the GITuD Group

Mercedes Salgado Fernández,

Margarita Reboredo López,

Marta Covela Rúa

et al.

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Cited by 1 publication

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Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer

Shan,

Tian,

Zhang

et al. 2024

Cancer Biology & Therapy

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Colorectal Cancer (CRC) is the third most common cancer worldwide, and the occurrence and development of CRC are influenced by the molecular biology characteristics of CRC, especially alterations in key signaling pathways. The transforming growth factor-β (TGF-β) plays a crucial role in cellular growth, differentiation, migration, and apoptosis, with SMAD4 protein serving as a key transcription factor in the TGF-β signaling pathway, thus playing a significant role in the onset and progression of CRC. CRC is one of the malignancies with a high mortality rate worldwide. Despite significant research progress in recent years, especially regarding the role of SMAD4, its dual role in the early and late stages of tumor progression has promoted further discussion on its complexity as a therapeutic target, highlighting the urgent need for a deeper analysis of its role in CRC. This review aims to explore the function of SMAD4 protein in CRC and its potential as a therapeutic target.

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Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer

Shan,

Tian,

Zhang

et al. 2024

Cancer Biology & Therapy

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show abstract

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Rechallenge with Anti-EGFR Treatment in RAS/BRAF wt Metastatic Colorectal Cancer (mCRC) in Real Clinical Practice: Experience of the GITuD Group

Cited by 1 publication

References 26 publications

Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer

Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer

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