Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer
Hui Shan,
Guangyu Tian,
Yeqing Zhang
et al.
Abstract:Colorectal Cancer (CRC) is the third most common cancer worldwide, and the occurrence and development of CRC are influenced by the molecular biology characteristics of CRC, especially alterations in key signaling pathways. The transforming growth factor-β (TGF-β) plays a crucial role in cellular growth, differentiation, migration, and apoptosis, with SMAD4 protein serving as a key transcription factor in the TGF-β signaling pathway, thus playing a significant role in the onset and progression of CRC. CRC is on… Show more
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