Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients

Kadkhodazadeh, Mahdi; Baghani, Zahra; Ebadian, Ahmad Reza; Kaghazchi, Zahra; Amid, Reza

doi:10.5051/jpis.2014.44.3.141

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Gurol [29] evaluated 39 patients with implants and found no statistical relationship between IL-10 polymorphism (-1082) and implant failure, our study confirms these findings. Also, in the same line as our study, other authors suggested that the TNF-a-308 G/A polymorphism was not associated with early implant failure [38], [39]. Now, Jacobi-Gresser [40], differing from our study, observed that GA or AA genotypes of the TNF-α polymorphism (G-308A) are more frequent in cases and are associated with an increased risk of implant failure.…”

Section: Methodssupporting

confidence: 88%

IL-10 A/G rs1800896 and TNF-α G308A rs1800629 Polymorphisms and Their Relationship with the Risk of Implant Loss in Adult Patients from Argentina

et al. 2023

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Introduction: the results of treatment in implantology have been evaluated mainly as implant survival rates in small groups of patients selected from specialized clinical or university settings. There is evidence to support polymorphisms that could be linked to some biological complications in implantology. The results may vary according to the origin or ethnic mixtures of the population studied. The objective of this study was to analyze the relationship between the polymorphisms IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 and the loss of dental implants and periodontal disease. Material and method: 140 patients were selected, 10 with implant losses within a maximum period of 6 months of their placement. Each patient voluntarily consented to participate in the study (approved by CIEIS Adult Hospital Córdoba) Filiatory and clinical data were collected in a clinical history. Samples of clinically healthy oral mucosa were obtained and genotyped by PCR and RFPL. Results: The population consisted of male and female individuals in similar proportions (p=0.6121). The average age was 53.06±16.22 years, and an age variation range of 20 to 80 years. 7.7% of the patients included in the study had loss of their implant. It was observed that 62.5% of the patients who presented loss of implants were women. Of the patients with missing implants, 75% were smokers and did not consume alcohol. On the other hand, in relation to periodontal disease only 31% presented disease. In relation to genotype, patients with lost implants had 50% of the mutated allele of the SNP TNFα rs1800629, while 50% of patients with periodontal disease were carriers of the mutated allele for SNP IL-10 rs1800896. On the other hand, considering the total population under study, 31.06% of the patients presented the genotypes with the genetic variation, AG+GG, of the IL10 rs1800896 gene; while 64.07% presented the AA and GA genotypes, (both with the mutated allele) of the TNF-α G308A rs1800629 gene. No significant association (p=0.3298) was observed between IL10 rs1800896 genotypes and periodontal disease; contrary to whether there was a significant relationship of this SNP with periodontal disease (p=0.0164). Conclusion: The polymorphisms evaluated were not predictive of the failure of dental implants. However, a significant association between periodontal disease and TNF-α rs1800629 genotype could be observed. It is noteworthy that this is the first study that describes the frequency of the SNPs studied in a population of Córdoba–Argentina.

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Section: Methodssupporting

confidence: 88%

IL-10 A/G rs1800896 and TNF-α G308A rs1800629 Polymorphisms and Their Relationship with the Risk of Implant Loss in Adult Patients from Argentina

et al. 2023

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“…This pathway is known to play an important role in RA pathogenesis (40). In periimplantitis, the NFkB ligand (RANKL) has been reported to be of importance (41).…”

Section: Discussionmentioning

confidence: 99%

“…This pathway is known to play an important role in RA pathogenesis ( 40 ). In periimplantitis, the NFkB ligand (RANKL) has been reported to be of importance ( 41 ). Interestingly, RANKL is increased by the action of lipopolysaccharides from Porphyromonas gingivalis (Pg) in the periimplant tissue ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Similarity and Potential Relation Between Periimplantitis and Rheumatoid Arthritis on Transcriptomic Level: Results of a Bioinformatics Study

Zhou

et al. 2021

Front. Immunol.

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BackgroundThis bioinformatics study aimed to reveal potential cross-talk genes, related pathways, and transcription factors between periimplantitis and rheumatoid arthritis (RA).MethodsThe datasets GSE33774 (seven periimplantitis and eight control samples) and GSE106090 (six periimplantitis and six control samples) were included from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO). A differential expression analysis (p < 0.05 and |logFC (fold change)| ≥ 1) and a functional enrichment analysis (p < 0.05) were performed. Based on this, a protein–protein interaction (PPI) network was constructed by Cytoscape. RA-related genes were extracted from DisGeNET database, and an overlap between periimplantitis-related genes and these RA-related genes was examined to identify potential cross-talk genes. Gene expression was merged between two datasets, and feature selection was performed by Recursive Feature Elimination (RFE) algorithm. For the feature selection cross-talk genes, support vector machine (SVM) models were constructed. The expression of these feature genes was determined from GSE93272 for RA. Finally, a network including cross-talk genes, related pathways, and transcription factors was constructed.ResultsPeriimplantitis datasets included 138 common differentially expressed genes (DEGs) including 101 up- and 37 downregulated DEGs. The PPI interwork of periimplantitis comprised 1,818 nodes and 2,517 edges. The RFE method selected six features, i.e., MERTK, CD14, MAPT, CCR1, C3AR1, and FCGR2B, which had the highest prediction. Out of these feature genes, CD14 and FCGR2B were most highly expressed in periimplantitis and RA. The final activated pathway–gene network contained 181 nodes and 360 edges. Nuclear factor (NF) kappa B signaling pathway and osteoclast differentiation were identified as potentially relevant pathways.ConclusionsThis current study revealed FCGR2B and CD14 as the most relevant potential cross-talk genes between RA and periimplantitis, which suggests a similarity between RA and periimplantitis and can serve as a theoretical basis for future research.

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Signaling pathways of dental implants’ osseointegration: a narrative review on two of the most relevant; NF-κB and Wnt pathways

Emam,

Moussa

2024

BDJ Open

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Introduction Cell signaling pathways are the biological reactions that control cell functions and fate. They also directly affect the body reactions to implanted biomaterials. It is well-known that dental implants success depends on a successful integration with the alveolar bone: “osseointegration” which events comprise early and later responses to the implanted biomaterials. The early events are mainly immune-inflammatory responses to the implant considered by its microenvironment as a foreign body. Later reactions are osteogenic aiming to regulate bone formation and remodeling. All these events are controlled by the cell signaling pathways in an incredible harmonious coordination. Aim The number of pathways having a role in osseointegration is so big to be reviewed in a single article. So the aim of this review was to study only two of the most relevant ones: the inflammatory Nuclear Factor Kappa B (NF-κB) pathway regulating the early osseointegration events and the osteogenic Wnt pathway regulating later events. Methods We conducted a literature review using key databases to provide an overview about the NF-κB and Wnt cell signaling pathways and their mutual relationship with dental implants. A simplified narrative approach was conducted to explain these cell signaling pathways, their mode of activation and how they are related to the cellular events of osseointegration. Results and conclusion NF-κB and Wnt cell signaling pathways are important cross-talking pathways that are affected by the implant’s material and surface characteristics. The presence of the implant itself in the bone alters the intracellular events of both pathways in the adjacent implant’s cellular microenvironment. Both pathways have a great role in the success or failure of osseointegration. Such knowledge can offer a new hope to treat failed implants and enhance osseointegration in difficult cases. This is consistent with advances in Omics technologies that can change the paradigm of dental implant therapy.

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Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients

Cited by 7 publications

References 22 publications

IL-10 A/G rs1800896 and TNF-α G308A rs1800629 Polymorphisms and Their Relationship with the Risk of Implant Loss in Adult Patients from Argentina

IL-10 A/G rs1800896 and TNF-α G308A rs1800629 Polymorphisms and Their Relationship with the Risk of Implant Loss in Adult Patients from Argentina

Similarity and Potential Relation Between Periimplantitis and Rheumatoid Arthritis on Transcriptomic Level: Results of a Bioinformatics Study

Signaling pathways of dental implants’ osseointegration: a narrative review on two of the most relevant; NF-κB and Wnt pathways

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