Recent Updates in Pharmacological Properties of Chitooligosaccharides

Marmouzi, Ilias; Ezzat, Shahira M.; Salama, Maha M.; Merghany, Rana M.; Attar, Aisha; El-Desoky, Ahmed M; Saat, Mohamed

doi:10.1155/2019/4568039

Cited by 20 publications

(16 citation statements)

References 112 publications

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“…Previous studies have shown the antimicrobial [21], anti-inflammatory [22], antitumoral [23], and antioxidant [24] activities of COSs, as well their potential use in Alzheimer disease [25]. More details on the biological properties and applications of COSs are described elsewhere [26,27]. Recently, COSs have been exploited in nanotechnology aiming to tackle microbial resistance [28], and also tumor imaging and therapy [29] and drug-delivery [30].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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The global rise of infectious disease outbreaks and the progression of microbial resistance reinforce the importance of researching new biomolecules. Obtained from the hydrolysis of chitosan, chitooligosaccharides (COSs) have demonstrated several biological properties, including antimicrobial, and greater advantage over chitosan due to their higher solubility and lower viscosity. Despite the evidence of the biotechnological potential of COSs, their effects on trypanosomatids are still scarce. The objectives of this study were the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of COSs. NMR and mass spectrometry analyses indicated the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no evidence of cytotoxicity upon 2 mg/mL. In addition, COSs showed interesting activity against bacteria and yeasts and a time-dependent parasitic inhibition. Scanning electron microscopy images indicated a parasite aggregation ability of COSs. Thus, the broad biological effect of COSs makes them a promising molecule for the biomedical industry.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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“…Anti-inflammatory activities of different CHOS mixtures with various compositions obtained from diverse preparation methods have been reported using different assay systems, such as mouse models and various cell lines including murine RAW 264.7 macrophages, murine microglial cell line BV-2 , and human endothelial T84 cells [ 2 , 31 ]. To the best of our knowledge, this is the first report on the anti-inflammatory activity of CHOS on human monocytes.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory activity of soluble chito-oligosaccharides (CHOS) on VitD3-induced human THP-1 monocytes

et al. 2021

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Chito-oligosaccharides (CHOS) are oligomers of D-glucosamine and N-acetyl-glucosamine. Anti-inflammatory activities of a wide variety of CHOS mixtures have previously been reported, mainly based on studies with mouse models and murine macrophages. Since the mouse and human immune systems are quite different, gaining insight into the activity of CHOS on human cell lines, using well-characterized CHOS mixtures, is of considerable interest. Bacillus subtilis chitosanase (BsCsn46A) can efficiently convert chitosan to mixtures of water soluble low molecular weight CHOS. Here, the anti-inflammatory activity of a properly characterized CHOS mixture was studied, using human THP-1 cells that were differentiated to mature monocytes using vitamin D3. Addition of CHOS reduced the production of multiple pro-inflammatory cytokines associated with bacterial lipopolyssacharide (LPS)-stimulated inflammation, in a dose-dependent manner and without affecting cell viability. Interestingly, only minimal effects of CHOS were observed in similar experiments with phorbol 12-myristate 13-acetate- (PMA-) differentiated, macrophage-like, THP-1 cells. Altogether, in addition to showing promising biological effects of well-characterized low molecular weight soluble CHOS in a human system, the present study also points at Vitamin D3-stimulated THP-1 cells as a favorable system for assessing the anti-inflammatory activity of bioactive compounds.

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“…The application of CAR-CHIOS complexes can result in the synergistic effect. CHIOS exhibit anti-oxidant, anti-inflammatory and anti-cancer activities [ 22 , 23 ], positively affect probiotic bacteria [ 24 ] and have antimicrobial activity [ 25 ]. Moreover, chitosan, from which CHIOS are produced by enzymatic or chemical hydrolysis is approved as a food additive and introduced in the European Pharmacopeia and the US National Formulary in 2008 and 2011, respectively.…”

Section: Introductionmentioning

confidence: 99%

New β-Carotene-Chitooligosaccharides Complexes for Food Fortification: Stability Study

Bočkuvienė

Sereikaitė

2020

Foods

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The application of β-carotene in food industry is limited due to its chemical instability. The drawback may be overcome by designing new delivery systems. The stability of β-carotene complexed with chitooligosaccharides by kneading, freeze-drying and sonication methods was investigated under various conditions. The first-order kinetics parameters of the reaction of β-carotene degradation were calculated. The complexation improved the stability of β-carotene at high temperatures and ensured its long-term stability in the dark at 4 °C and 24 °C, and in the light at 24 °C. In water solutions, the best characteristics were exhibited by the complexes prepared by freeze-drying and sonication methods. In the powder form, the complexes retained their colour for the period of the investigation of four months. The calculated total colour differences of the complexes were qualified as appreciable, detectable by ordinary people, but not large. Therefore, β-carotene-chitooligosaccharides complexes could be used as a new delivery system suitable for food fortification.

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Recent Updates in Pharmacological Properties of Chitooligosaccharides

Cited by 20 publications

References 112 publications

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Anti-inflammatory activity of soluble chito-oligosaccharides (CHOS) on VitD3-induced human THP-1 monocytes

New β-Carotene-Chitooligosaccharides Complexes for Food Fortification: Stability Study

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