Recent update on alginate based promising transdermal drug delivery systems

Manna, Sreejan; Gupta, Prajna; Nandi, Gouranga; Jana, Sougata

doi:10.1080/09205063.2023.2230847

Cited by 5 publications

(1 citation statement)

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“…All samples were measured on the OCA20 contact angle measurement system (data physics) and surface energy was calculated. , Using a syringe, 5 μL of water or diiodomethane was carefully deposited on the surface of the PSA. At least three different points were measured on the same sample surface to give an average value.…”

Section: Methodsmentioning

confidence: 99%

A Rhamnose-PEG-Modified Dendritic Polymer for Long-Term Efficient Transdermal Drug Delivery

Song,

Cai,

Nan

et al. 2024

ACS Appl. Mater. Interfaces

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This study introduces a dendronized pressuresensitive adhesive, TMPE@Rha, addressing Food and Drug Administration (FDA) concerns about traditional pressuresensitive adhesives (PSAs) in transdermal drug delivery systems. The unique formulation, composed of rhamnose, trihydroxypropane, and poly(ethylene glycol), significantly enhances cohesion and tissue adhesion. Leveraging rhamnose improves intermolecular interactions and surface chain mobility, boosting tissue adhesion. Compared to acrylic pressure-sensitive adhesive 87-DT-4098, TMPE@Rha shows substantial advantages, with up to 5 to 6 times higher peel strength on porcine and wood substrates. Importantly, it maintains strong human skin adhesion beyond 7 days without the typical "dark ring" phenomenon. When loaded with diclofenac, the adhesive exhibits 3.12 times greater peeling strength than commercial alternatives, sustaining human adhesion for up to 6 days. Rigorous analyses confirm rhamnose's role in increasing interaction strength. In vitro studies and microscopy demonstrate the polymer's ability to enhance drug loading and distribution on the skin, improving permeability. Biocompatibility tests affirm TMPE@Rha as nonirritating. In summary, TMPE@Rha establishes a new standard for PSAs in transdermal drug delivery systems, offering exceptional adhesion, robustness, and biocompatibility. This pioneering work provides a blueprint for nextgeneration, highly adhesive, drug-loaded PSAs that meet and exceed FDA criteria.

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Section: Methodsmentioning

confidence: 99%