Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices

Babu, Molakpogu Ravindra; Vishwas, Sukriti; Khursheed, Rubiya; Harish, Vancha; Sravani, Anne Boyina; Khan, Farhan; Alotaibi, Bader; Binshaya, Abdulkarim; Disouza, John; Kumbhar, Popat S.; Patravale, Vandana; Gupta, Gaurav; Loebenberg, Raimar; Arshad, Mohammed Faiz; Patel, Archita; Patel, Samir; Dua, Kamal; Singh, Sachin Kumar

doi:10.1007/s13346-023-01475-9

Drug Deliv. and Transl. Res.

2023

DOI: 10.1007/s13346-023-01475-9

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Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices

Molakpogu Ravindra Babu,

Sukriti Vishwas,

Rubiya Khursheed

et al.

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2024

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Cited by 7 publications

References 255 publications

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Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Haidari,

Bright,

et al. 2024

Small Science

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Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug delivery while complemented with noninvasiveness and patient compliance. Currently, the topical application of antimicrobials restricts the delivery of drugs to the critical areas of the wound bed, largely due to barriers posed by the necrotic tissue, scab formation, and bacterial biofilms, which severely diminish the bioavailability of the therapeutics. MNs have enabled efficient and targeted delivery to overcome many chronic wound challenges. Over the past decade, significant progress has been made to develop MNs with unique properties tailored for the delivery of vaccines, anticancer, and antimicrobials. As ongoing research continues to refine MN design, material properties, and drug formulations, the potential for revolutionizing antimicrobial drug delivery for efficacy, patient experience, and therapeutic outcomes remains at the forefront of scientific research. In this review, insights are provided into the latest progress, current developments, and the diverse applications of MNs for antimicrobial drug delivery. Herein, the translational potential of MNs is highlighted and a perspective on the current challenges associated with clinical translation is provided. Furthermore, this review aids in identifying research gaps while empowering and contributing to the future implementation of cutting‐edge delivery systems to effectively tackle antimicrobial resistance.

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Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Haidari,

Bright,

et al. 2024

Small Science

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Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs

Lin,

Liu,

Hou

et al. 2024

Drug Deliv. and Transl. Res.

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Bao,

Zhang,

Hao

et al. 2024

Nano-Micro Lett.

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The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier and corneal impermeability. Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance. Polysaccharide-based microneedles (PSMNs) have emerged as a transformative solution for ophthalmic drug delivery. However, a comprehensive review of PSMNs in ophthalmology has not been published to date. In this review, we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery. We provide a thorough analysis of PSMNs, summarizing the design principles, fabrication processes, and challenges addressed during fabrication, including improving patient comfort and compliance. We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios. Finally, we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

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Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices

Cited by 7 publications

References 255 publications

Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

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