Recent trends in smart polymeric coatings in biomedicine and drug delivery applications

Makhlouf, Abdel Salam Hamdy; Pérez, Adrián A.; Guerrero, Edgar

doi:10.1016/b978-0-12-849870-5.00019-7

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…Smart polymer coatings are the recent advancement in the polymer coatings. Various reports indicated that, polymer are smart and have the capability to respond to numerous stimuli, such as temperature, light, magnetic field, electric field and pH [ 1 ]. In the medical field, these smart polymers are mainly used in drug delivery applications where the drugs can be loaded in these polymer or polymer coatings and can be delivered at the chosen location with the aid of a stimuli.…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Introductionmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…In situ hydrogels are formed by stimulus-sensitive polymers that, once administered to the body, undergo an in situ gelation, forming a hydrogel. 100 , 101 Stimulus-sensitive polymers are classified according to the type of stimulus to which they respond: 102 , 103 i) polymers that respond to biological stimuli (enzymes and biomolecules); ii) polymers that respond to chemical stimuli (pH and ionic strength); iii) polymers that respond to physical stimulus (temperature, ultrasound, light, mechanical stress).…”

Section: Current Strategies To Improve the Treatment Of Alzheimer’s Diseasementioning

confidence: 99%

Improving Drug Delivery for Alzheimer’s Disease Through Nose-to-Brain Delivery Using Nanoemulsions, Nanostructured Lipid Carriers (NLC) and in situ Hydrogels

Cunha¹,

Forbes²,

Lobo³

et al. 2021

IJN

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Current treatments for Alzheimer’s disease (AD) attenuate the progression of symptoms and aim to improve the patient’s quality of life. Licensed medicines are mostly for oral administration and are limited by the difficulty in crossing the blood–brain barrier (BBB). Here in, the nasal route has been explored as an alternative pathway that allows drugs to be directly delivered to the brain via the nasal cavity. However, clearance mechanisms in the nasal cavity impair the delivery of drugs to the brain and limit their bioavailability. To optimize nose-to-brain delivery, formulations of lipid-based nanosystems, namely nanoemulsions and nanostructured lipid carriers (NLC), formulated in situ gelling hydrogels have been proposed as approaches for nose-to-brain delivery. These formulations possess characteristics that facilitate drug transport directly to the brain, minimizing side effects and maximizing therapeutic benefits. It has been recommended that the manufacture of these drug delivery systems follows the quality by design (QbD) approach based on nasal administration requirements. This review provides an insight into the current knowledge of the AD, highlighting the need for an effective drug delivery to the brain. Considering the mounting interest in the use of nanoemulsions and NLC for nose-to-brain delivery, a description of drug transport pathways in the nasal cavity and the application of these nanosystems and their in situ hydrogels through the intranasal route are presented. Relevant preclinical studies are summarised, and the future prospects for the use of lipid-based nanosystems in the treatment of AD are emphasized.

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“…[ 1,128,129 ] For example, the poly( N ‐isopropylacrylamide) (PNIPAm) is a thermosensitive material showing a substantial volume change when heated above a lower critical solution temperature as water is expelled during a phase transition. [ 130 ] Accordingly, water‐sorption‐induced swelling can be utilized for actuation by applying an inhomogeneous field such as a gradient of temperature, or by using inhomogeneous materials exploiting a gradient of swelling properties. [ 131 ] For instance, Ma et al.…”

Section: Functional Materials and Mechanismsmentioning

confidence: 99%

Foundations for Soft, Smart Matter by Active Mechanical Metamaterials

Pishvar

Harne

2020

Advanced Science

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Emerging interest to synthesize active, engineered matter suggests a future where smart material systems and structures operate autonomously around people, serving diverse roles in engineering, medical, and scientific applications. Similar to biological organisms, a realization of active, engineered matter necessitates functionality culminating from a combination of sensory and control mechanisms in a versatile material frame. Recently, metamaterial platforms with integrated sensing and control have been exploited, so that outstanding non‐natural material behaviors are empowered by synergistic microstructures and controlled by smart materials and systems. This emerging body of science around active mechanical metamaterials offers a first glimpse at future foundations for autonomous engineered systems referred to here as soft, smart matter. Using natural inspirations, synergy across disciplines, and exploiting multiple length scales as well as multiple physics, researchers are devising compelling exemplars of actively controlled metamaterials, inspiring concepts for autonomous engineered matter. While scientific breakthroughs multiply in these fields, future technical challenges remain to be overcome to fulfill the vision of soft, smart matter. This Review surveys the intrinsically multidisciplinary body of science targeted to realize soft, smart matter via innovations in active mechanical metamaterials and proposes ongoing research targets that may deliver the promise of autonomous, engineered matter to full fruition.

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Recent trends in smart polymeric coatings in biomedicine and drug delivery applications

Cited by 12 publications

References 20 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Improving Drug Delivery for Alzheimer’s Disease Through Nose-to-Brain Delivery Using Nanoemulsions, Nanostructured Lipid Carriers (NLC) and in situ Hydrogels

Foundations for Soft, Smart Matter by Active Mechanical Metamaterials

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