Recent translational research: computational studies of breast cancer

Abstract

The combination of mathematics -queen of sciences -and the general utility of computers has been used to make important inroads into insight-providing breast cancer research and clinical aids. These developments are in two broad areas. First, they provide useful prognostic guidelines for individual patients based on historic evidence. Second, by suggesting numeric tumor growth laws that are correlated to clinical parameters, they permit development of biologically relevant theories and comparison with patient data to help us understand complex biologic processes. These latter studies have produced many new ideas that are testable in clinical trials. In this review we discuss these developments from a clinical perspective, and ask whether and how they translate into useful tools for patient treatment.

The dynamics of drug resistance: A mathematical perspective

“…Several review papers have been published on mathematics and drug resistance (Agur, 2010; Chapman et al, 2007; Clare et al, 2000; Fister and Panetta, 2000; Foo and Michor, 2010; Gardner, 2002a; Gardner and Fernandes, 2003; Goldie and Coldman, 1998; Kufe et al, 2003; Michelson, 1993; Michor et al, 2006; Panagiotopoulou et al, 2010; Piccart-Gebhart, 2003; Retsky et al, 2005; Simon and Norton, 2006; Swierniak et al, 2009; Wodarz and Komarova, 2005). In view of the present understanding of MDR, it turns out that most of the review papers have focused on a subset of the issues related to drug resistance.…”

Research on the Construction Method of Knowledge Base of Automatic Question Answering System for Labor Law

“…FastGPT is currently the best project for Prompt concatenation, and then we need to log in to the Docker official website to install the Docker application, and then configure the file to create a folder config.json, and then create a dockercompose.yml file, modify the CHAT_API_KEY in the docker-compose.yml to My OpenAI Key, and then start executing the command to start the local knowledge base, Once the execution is complete, you can access your personal knowledge base on your browser via the http://localhost:3000/ URL. [2]…”

“…The login username is **, and the password is the DEFAULT_ROOT_PSW set in the ** environment variable. [2]…”

New Concepts in Breast Cancer Emerge from Analyzing Clinical Data Using Numerical Algorithms

“…I have published my findings that the entire experimental basis for Gompertzian kinetics lies in the 1960s era Laird papers [ 49 – 54 ]. Laird measured growth of “19 examples of 12 different tumors of the rat, mouse, and rabbit” and concluded: “The pattern of growth defined by the Gompertz equation appears to be a general biological characteristic of tumor growth.” That is a far reaching statement based on only 18 rodents and one rabbit.…”