New Concepts in Breast Cancer Emerge from Analyzing Clinical Data Using Numerical Algorithms

Retsky, Michael

doi:10.3390/ijerph6010347

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…Moreover, a double peaked relapse pattern of breast cancer recurrence has been described, suggesting the risk of metastasis is not constant over time [ 30 – 34 ]. The first peak starts 10 months after the operation and reaches its maximum approximately 18–24 months after surgery.…”

Section: Discussionmentioning

confidence: 99%

Oncological safety of autologous breast reconstruction after mastectomy for invasive breast cancer

et al. 2018

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BackgroundThe number of patients requesting autologous breast reconstruction (ABR) after mastectomy for breast cancer has increased over the past decades. However, concern has been expressed about the oncological safety of ABR. The aim of our study was to assess the effect of ABR on distant relapse.MethodsIn this retrospective cohort study, data was analysed from patients who underwent mastectomy for invasive breast cancer in University Hospitals Leuven between 2000 and 2011. In total, 2326 consecutive patients were included, 485 who underwent mastectomy with ABR and 1841 who underwent mastectomy alone. The risk of relapse in both groups was calculated using a Cox proportional hazards analysis, adjusted for established prognostic factors. ABR was considered as a time-dependent variable. Additionally, the evolution of the risk over follow-up time was calculated.ResultsWith a median follow-up of 68 months, 8% of patients in the reconstruction group developed distant metastases compared to 15% in the mastectomy alone group (univariate HR 0.70, 95% CI 0.50–0.97, p = 0.0323). However, after adjustment for potential confounding factors in a Cox multivariable analysis, the risk of distant relapse was no longer significantly different between groups (multivariate HR 0.82, 95% CI 0.55–1.22, p = 0.3301). Moreover, the risk of metastasis after reconstruction was not time-dependent.ConclusionsThese findings suggest that there is no effect of ABR on distant relapse rate and thus that ABR is an oncological safe procedure. The rate of local recurrence was too low to make any significant conclusions.

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Section: Discussionmentioning

confidence: 99%

Oncological safety of autologous breast reconstruction after mastectomy for invasive breast cancer

et al. 2018

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“…The importance of understanding the surgical inflammatory response is further highlighted in the developing field of oncoanesthesiology, in which anesthesia technique and perioperative strategies, potentially including anti-inflammatory strategies, may impact early risk of recurrence during the first two postoperative years after cancer surgery [48][49][50][51]. The importance of understanding the surgical inflammatory response is further highlighted in the developing field of oncoanesthesiology, in which anesthesia technique and perioperative strategies, potentially including anti-inflammatory strategies, may impact early risk of recurrence during the first two postoperative years after cancer surgery [48][49][50][51].…”

Section: Potential Perioperative Strategiesmentioning

confidence: 99%

Cerebral protection

Riedel

Browne

Silbert

2014

Current Opinion in Anaesthesiology

103

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Recent research points to a central role of a neuro-inflammatory cascade in POCD, with endothelial dysfunction potentially aggravating the insult. Investigating the genomic and molecular mechanisms that underlie the intervariation in the inflammatory response to surgery, improving the identification of appropriate endothelial and inflammatory biomarkers, and developing endothelial modulatory and anti-inflammatory (prevention and resolution) strategies are key areas of future translational research. This is important as the elderly, who show increased susceptibility to this and other perioperative illness syndromes, represent an ever-increasing proportion of patients presenting for surgery.

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“…If anyone is wondering how a medical researcher can be a guest editor of a journal dedicated to ANN, I am a classically trained experimental physicist but made a career change into cancer research a number of years ago. This was recently documented in a sister MDPI journal [ 11 ].…”

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confidence: 63%

Guest Editor’s Concluding Remarks―Advances in Usage of ANN, Discussion of an Unsolved Problem, and Some Differences between Papers Written by Engineers and by Physicians

Retsky

2009

Sensors

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I take this opportunity to discuss a few things that I have learned from being Guest Editor of this special issue of Sensors devoted to Neural Networks and Sensors. The advancement in artificial neural network (ANN) technology is very impressive. The wide variety of fields in which this technology applies in the form of practical applications to clearly identifiable real problems demonstrates that ANNs are being routinely used to solve non-trivial problems. I mention that because A. K. Dewdney wrote in 1997 that while ANNs have been used to solve a few toy problems, he was surprised that anyone takes them seriously as general problem-solving tools [1]. The ANN applications reported by Yu Liu et al. [2], Erkan Beşdok [3], Guillermo Zatorre et al. [4], Amir Jabbari et al. [5], Mohamed Lamine Hafiane et al. [6], Kai-Wei Chiang et al. [7], Raúl Vicen-Bueno et al. [8], Juan L. Pedreño-Molina et al. [9], and P. B. Garcia-Allende et al. [10] are far more than toy applications. The lesson to be learned here is that it is a bad idea to publically bet against technological progress in computer applications. [...

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New Concepts in Breast Cancer Emerge from Analyzing Clinical Data Using Numerical Algorithms

Cited by 5 publications

References 48 publications

Oncological safety of autologous breast reconstruction after mastectomy for invasive breast cancer

Oncological safety of autologous breast reconstruction after mastectomy for invasive breast cancer

Cerebral protection

Guest Editor’s Concluding Remarks―Advances in Usage of ANN, Discussion of an Unsolved Problem, and Some Differences between Papers Written by Engineers and by Physicians

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