Recent technologies in pulsatile drug delivery systems

Jain, Deepika; Raturi, Richa; Jain, Vikas; Bansal, Praveen; Singh, Ranjit

doi:10.4161/biom.1.1.17717

Cited by 105 publications

(64 citation statements)

References 43 publications

(26 reference statements)

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“…Usually, sustained or pulsatile drug release is achieved by using controlled release of drug delivery (Hilt & Peppas, 2005) which means the rapid and transient release of a certain amount of molecules within a short time-period immediately after a predetermined off-release period (Figure 2; Jain et al, 2011). This delivery method works better in certain cases because it closely mimics the way in which the human body naturally produces some compounds (Santini et al, 2000a).…”

Section: Controlled Release and Pulsatile Release Of Drugmentioning

confidence: 99%

“…oral tablets, injections, pulmonary, transdermal (Shawgo et al, 2002;Tao & Desai, 2003;Hilt & Peppas, 2005;Chien & Lin 2006), aerosols and ointments (Langer, 1990) could provide one or more of the following benefits compared to conventional dosage forms including (Langer, 1990;Putney & Burke, 1998;Medlicott & Tucker, 1999;Hilt & Peppas, 2005;Chien & Lin 2006;Jain et al, 2011;Lee et al, 2012;Siegel & Rathbone, 2012) the following factors.…”

Section: Controlled Release and Pulsatile Release Of Drugmentioning

confidence: 99%

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Implantable microchip: the futuristic controlled drug delivery system

2014

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There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized.

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Section: Controlled Release and Pulsatile Release Of Drugmentioning

confidence: 99%

Section: Controlled Release and Pulsatile Release Of Drugmentioning

confidence: 99%

Implantable microchip: the futuristic controlled drug delivery system

2014

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“…The collected blood from the heart puncture was allowed to coagulate for 30 minutes, and serum was separated by centrifugation at 2500 rpm [8]. The serum was used to estimate serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase, alkaline phosphate, total protein, albumin, globulin, total bilirubin, total cholesterol, and high-density lipoprotein.…”

Section: Non-clinical Investigations Of a Formulation Rf1mentioning

confidence: 99%

In Vivo Hepatoprotective Activity of Cassia Auriculata Polymer Nanospheres Containing Silymarin

Sagar

Rao²

2016

Asian J Pharm Clin Res

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Objective: Hepatoprotective activity of herbal drugs has an importance in the treatment of hepatic disorders, but pharmaceutically engineered products are not evolved properly to cure the liver disorders properly based on the demand and also route, target the appropriate site of action. Methods:In our present work, we have been developed a new formulation that possesses a unique nature and site specificity for targeting the disease state. Here, we examined hepatoprotective activity of Cassia auriculata polymer nanospheres containing silymarin against carbon tetrachlorideinduced hepatotoxicity in rats using at 50 mg/kg and 100 mg/kg body weight dose levels, and we have been observed that enzyme activities of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphate, total protein, albumin, globulin, total cholesterol, high-density lipoprotein (HDL), glutathione (GSH), and total bilirubin were analyzed.Results: C. auriculata polymer nanospheres and silymarin produced significant (p<0.001) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, total cholesterol, and increased levels of HDL, total protein, albumin, globulin, and tissue GSH. Conclusion:From these results, it was concluded that of C. auriculata polymer nanospheres would protect the liver cells from carbon tetrachloride from liver diseases.

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“…The carbon dioxide developed after penetration of water into the core resulted in a pulsatile release of drug after rupture of the coating. The release may depend on the mechanical properties of the coating layer 42 .…”

Section: ) Multilayered Tabletsmentioning

confidence: 99%

Untitled

2013

IJPSR

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Chronotherapy refers to the use of circadian, ultradian, infradian & seasonal or other rhythmic cycles in the application of therapy. There are number of conditions which show a circadian pattern and advantage could be taken by timing and adjusting the administration of drugs according to the circadian rhythm of the disease. Some of the conditions, which may be significantly benefited, are hypertension, myocardial infarction, bronchial asthma, peptic ulcer, arthritis, duodenal ulcer, diabetes, neurological disorder, cancer and hypercholesterolemia. Chronotherapy can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. INTRODUCTION: Circadian rhythm regulates many body functions in humans, like metabolism, physiology, behaviour, sleep patterns, hormone production, etc. The release of some drugs is preferred in pulses i.e. the release of drug as a "pulse" after a lag time has to be designed in such a way that a complete and rapid drug release should follow the lag time.Lag time is defined as the time between when a dosage form is placed into an aqueous environment and the time at which the active ingredient begins to release from the dosage form. These systems are also called time-controlled as the drug released is independent of the environment 1 .A single dosage form provides an initial dose of drug followed by one release-free interval, after which second dose of drug is released, which is followed by additional release-free interval and pulse of drug release 2 .Chronopharmaceutics is a branch of pharmaceutics (science and technology of drug dosage forms) meant to the design and evaluation of drug delivery systems that release a bioactive agent at a rhythm that ideally matches in real time the biological requirement for a given disease therapy or prevention 'Chronopharmaceutic Drug Delivery System' uses the basic concepts of human chronobiology and the rhythm dependence of certain disease states and the pharmacodynamics of medications.The drug therapy can be optimized by tailoring the dosing schedule based on chronobiological pattern.

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Recent technologies in pulsatile drug delivery systems

Cited by 105 publications

References 43 publications

Implantable microchip: the futuristic controlled drug delivery system

Implantable microchip: the futuristic controlled drug delivery system

In Vivo Hepatoprotective Activity of Cassia Auriculata Polymer Nanospheres Containing Silymarin

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