Recent studies on micro-/nano-sized biomaterials for cancer immunotherapy

Park, Ok; Yu, Gyeonghui; Jung, Heejung; Mok, Hyejung

doi:10.1007/s40005-016-0288-2

Cited by 34 publications

(7 citation statements)

References 46 publications

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“…Recent progress in nanotechnology has brought the development of nanoparticles as an advanced carrier delivering drugs [19,20,21,22]. These nanoparticles include liposomes [23,24], polymeric nanoparticles [25,26], solid lipid nanoparticles [27,28], micelles [29,30], nanostructured lipid carriers [31,32], nanoemulsions [18,33], and gold nanoparticles [34]. In a field of brain-targeted drug delivery, drug encapsulation in nanoparticles, after systemic administration, conferred drugs receptor- or adsorption- mediated transcytosis or endocytosis mechanism to cross the BBB, thereby increasing the amount of drugs reaching the target site in the brain [35,36].…”

Section: Introductionmentioning

confidence: 99%

Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives

Hong

Choi³

et al. 2019

Pharmaceutics

116

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Restricted drug entry to the brain that is closely associated with the existence of the blood brain barrier (BBB) has limited the accessibility of most potential active therapeutic compounds to the brain from the systemic circulation. Recently, evidences for the presence of direct nose-to-brain drug transport pathways have been accumulated by several studies and an intranasal drug administration route has gained attention as a promising way for providing direct access to the brain without the needs to cross to the BBB. Studies aiming for developing nanoparticles as an intranasal drug carrier have shown considerable promise in overcoming the challenges of intranasal drug delivery route. This review gives a comprehensive overview of works having investigated liposomes as a potential vehicle to deliver drugs to the brain through nose-to-brain route while considering the excellent biocompatibility and high potential of liposomes for clinical development. Herein, studies are reviewed with special emphasis on the impact of formulation factors, such as liposome composition and surface modification of liposomes with targeting moieties, in addition to intranasal environmental factors that may affect the extent/site of absorption of intranasally administered, liposome-encapsulated drugs.

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Section: Introductionmentioning

confidence: 99%

Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives

Hong

Choi³

et al. 2019

Pharmaceutics

116

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“…Among the materials investigated for this purpose, marine polysaccharides, such as alginate, fucoidan, and carrageenan, have shown promise owing to their gel formation ability under mild conditions (Gutowska et al 2001;d'Ayala et al 2008), biocompatibility (Lee and Mooney 2012), biocompatibility, and non-cytotoxic properties (Martins et al 2015). These marine polysaccharides have been processed into scaffolds for tissue engineering, cancer therapy (Stephan et al 2015;Park et al 2017) and carriers of various tissue-regenerating agents, such as growth factors, DNA, and mRNAs for the production of proteins that contribute to tissue repair.…”

Section: Application Of Marine Polysaccharides In Tissue Engineeringmentioning

confidence: 99%

Marine polysaccharides: therapeutic efficacy and biomedical applications

et al. 2017

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The ocean contains numerous marine organisms, including algae, animals, and plants, from which diverse marine polysaccharides with useful physicochemical and biological properties can be extracted. In particular, fucoidan, carrageenan, alginate, and chitosan have been extensively investigated in pharmaceutical and biomedical fields owing to their desirable characteristics, such as biocompatibility, biodegradability, and bioactivity. Various therapeutic efficacies of marine polysaccharides have been elucidated, including the inhibition of cancer, inflammation, and viral infection. The therapeutic activities of these polysaccharides have been demonstrated in various settings, from in vitro laboratory-scale experiments to clinical trials. In addition, marine polysaccharides have been exploited for tissue engineering, the immobilization of biomolecules, and stent coating. Their ability to detect and respond to external stimuli, such as pH, temperature, and electric fields, has enabled their use in the design of novel drug delivery systems. Thus, along with the promising characteristics of marine polysaccharides, this review will comprehensively detail their various therapeutic, biomedical, and miscellaneous applications.

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“…Passive targeting occurs through interactions with the reticuloendothelial system, allowing for entry into the blood, which is dependent on particle size and surface characteristics. Development of nanoparticle anticancer drugs has improved therapeutic efficacy because the drug can be directly and selectively targeted to cancer cells [8,9,10]. For example, Kirtane et al [11] developed a polymer-surfactant nanoparticle composed of a sodium alginate core complexed with doxorubicin and the surfactant aerosol OT for stability.…”

Section: Introductionmentioning

confidence: 99%

Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs

et al. 2019

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Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic anticancer drugs) based on effectiveness and safety profile. Biologic drugs are administered by intravenous (IV) injection due to their large molecular weight, while small molecule drugs are preferentially administered by gastrointestinal route. Even though IV injection is the fastest route of administration and ensures complete bioavailability, this route of administration causes patient inconvenience to visit a hospital for anticancer treatments. In addition, IV administration can cause several side effects such as severe hypersensitivity, myelosuppression, neutropenia, and neurotoxicity. Oral administration is the preferred route for drug delivery due to several advantages such as low cost, pain avoidance, and safety. The main problem of NCEs is a limited aqueous solubility, resulting in poor absorption and low bioavailability. Therefore, improving oral bioavailability of poorly water-soluble drugs is a great challenge in the development of pharmaceutical dosage forms. Several methods such as solid dispersion, complexation, lipid-based systems, micronization, nanonization, and co-crystals were developed to improve the solubility of hydrophobic drugs. Recently, solid dispersion is one of the most widely used and successful techniques in formulation development. This review mainly discusses classification, methods for preparation of solid dispersions, and use of solid dispersion for improving solubility of poorly soluble anticancer drugs.

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Recent studies on micro-/nano-sized biomaterials for cancer immunotherapy

Cited by 34 publications

References 46 publications

Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives

Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives

Marine polysaccharides: therapeutic efficacy and biomedical applications

Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs

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