Recent Progress on Countercurrent Chromatography Modeling

Wang, Fengkang; Ito, Yoichiro; Wei, Yun

doi:10.1080/10826076.2014.941268

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…The mechanism of CCC is based on the compound distribution between two immiscible liquids which are called mobile phase and stationary phase, respectively. The previous report mentioned that CCC does not have several band-broadening mechanisms caused by the action of random imperfection in the flow stream like conventional chromatography because CCC does not have a solid support matrix in the column (Wang et al 2015 ). Therefore, CCC has a less complex mathematical description of the separation process than conventional liquid–liquid chromatography because in the conventional case, the liquid stationary phase is retained on a solid support.…”

Section: Separation and Characterizationmentioning

confidence: 99%

Extraction and characterization of phenolic compounds and their potential antioxidant activities

Shi

Zhao

Yang

et al. 2022

Environ Sci Pollut Res

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For thousands of years, plant has been widely applied in the medical area and is an important part of human diet. A high content of nutrients could be found in all kinds of plants, and the most outstanding group of nutrients that attracts scientists’ attention is the high level of phenolic compounds. Due to the relationship between high phenolic compound content and high antioxidant capacity, plant extracts are expected to become a potential treatment for oxidation stress diseases including diabetes and cancer. However, according to the instability of phenolic compounds to light and oxygen, there are certain difficulties in the extraction of such compounds. But after many years of development, the extraction technology of phenolic compounds has been quite stable, and the only problem is how to obtain high-quality extracts with high efficiency. To further enhance the value of plant extracts, concentration and separation methods are often applied, and when detailed analysis is required, characterization methods including HPLC and LC/GC–MS will be applied to evaluate the number and type of phenolic compounds. A series of antioxidant assays are widely performed in numerous studies to test the antioxidant capacity of the plant extracts, which is also an important basis for evaluating value of extracts. This paper intends to provide a view of a variety of methods used in plants’ phenolic compound extraction, separation, and characterization. Furthermore, this review presents the advantages and disadvantages of techniques involved in phenolic compound research and provides selected representative bibliographic examples.

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Section: Separation and Characterizationmentioning

confidence: 99%

Extraction and characterization of phenolic compounds and their potential antioxidant activities

Shi

Zhao

Yang

et al. 2022

Environ Sci Pollut Res

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“…This implies several advantages, such as the wide range of usable solvents, resulting in the possibility of tailor-made, highly optimized processes for a given separation task [1][2][3][4][5][6]. In this context, models for solvent selection were developed, allowing for a sophisticated choice of fluids [7][8][9][10][11][12]. Furthermore, liquid stationary phase costs are commonly less than solid material costs [1].…”

Section: Introductionmentioning

confidence: 99%

Spatially and Temporally Resolved Analysis of Bleeding in a Centrifugal Partition Chromatography Rotor

Buthmann,

Laby,

Hamza

et al. 2024

Separations

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Centrifugal Partition Chromatography (CPC) is a separation technique that utilizes immiscible liquid phases to purify compounds. The selection of solvents in Liquid–Liquid Chromatography offers flexibility and optimization possibilities for specific separation tasks. Understanding the hydrodynamics inside the apparatus is crucial for optimizing a CPC process. The phase retention ratio (Sf) determines the apparatus’s operating point and separation efficiency. However, stationary phase leakage, known as bleeding, complicates the immobilization of this phase. We used a partly transparent single-disc rotor to investigate the time and space dependency of bleeding inside a CPC apparatus, enabling real-time and localized determination of the phase retention ratio. By tracking the retention values over time, we observed the bleeding phenomenon and its progression from the inlet to the rotor outlet. Depending on the phase system used, the CPC was utilizable for a separation task for only 173–500 dimensionless residence times. Systems with a higher stability parameter (as described in the literature) showed a lower bleeding rate and increased stability over time. Accordingly, our results demonstrate the importance of maintaining an optimal ratio of mobile to stationary phase for efficient separation.

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“…It was found that the concentration of analyte in the incremental unit distributed follows the rules of binomial distribution, which was the initial of the development of CCC theory. At present, increasing numbers of literatures reported on modeling and prediction of CCC are available, however, only few number of reviews present this topic [28,29]. The published reviews included the prediction of partition coefficient for guiding the selection of solvent system and listed some of the models that were used to predict the retention of anayte in CCC, all of which were thermodynamic.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in separation prediction of counter‐current chromatography

Guo

Tong

Zhang

et al. 2020

J of Separation Science

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As a liquid‐liquid partition chromatography, counter‐current chromatography has advantages in large sample loading capacity without irreversible adsorption, which has been widely applied in separation and purification fields. The main factors, including partition coefficient, two‐phase solvent systems, apparatus, and operating parameters greatly affect the separation process of counter‐current chromatography. To promote the applications of counter‐current chromatography, it is essential to develop theoretical research to master the principles of counter‐current chromatographic separations so as to achieve predictions before laborious trials. In this article, recent progress about separation prediction methods are reviewed from a point of the steady and unsteady state of the mass transfer process of counter‐current chromatography and its mass transfer characteristics, and then it is divided into three aspects: prediction of partition coefficient, modeling the thermodynamic process of counter‐current chromatography, and modeling the dynamic process of counter‐current chromatography.

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Recent Progress on Countercurrent Chromatography Modeling

Cited by 11 publications

References 27 publications

Extraction and characterization of phenolic compounds and their potential antioxidant activities

Extraction and characterization of phenolic compounds and their potential antioxidant activities

Spatially and Temporally Resolved Analysis of Bleeding in a Centrifugal Partition Chromatography Rotor

Recent progress in separation prediction of counter‐current chromatography

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