Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism

Liu, Jiang; Ma, Lijun; Zhang, Guoyang; Chen, Yuzhi; Wang, Zhuo

doi:10.1021/acs.bioconjchem.1c00402

Cited by 29 publications

(6 citation statements)

References 128 publications

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“…The buildup of oxygen radicals causes oxidative stress, which enhances inflammation in a variety of illnesses, including chronic inflammatory diseases and neoplasms (Meng et al, 2021; Reuter, Gupta, Chaturvedi, & Aggarwal, 2010). Also, diabetes, cardiovascular disease, and neurodegenerative diseases are all manifestations of chronic oxidative stress (Ma, Zhang, Chen, & Wang, 2021; Yao, Wang, & Li, 2022; Zhao et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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“…It was demonstrated that as the SeNPs quantities rose from 6.5 to 106.3 mg/ml, scavenging capability improved dramatically from 48.45 ± 5.29 to 301.1 ± 11.42 mg/g. The SeNPs’ ability to neutralize these free radicals may be attributed to the dispersibility of the nanoparticles via media due to their tiny particle size, in addition to SeNPs’ high chemical activity [ 53 ]. The oxygen-releasing antioxidant might improve the adequacy with which cells multiply, migrate, proliferate, and spread, advancing the healing procedure.…”

Section: Resultsmentioning

confidence: 99%

Citric acid-mediated green synthesis of selenium nanoparticles: antioxidant, antimicrobial, and anticoagulant potential applications

Alhawiti

2022

Biomass Conv. Bioref.

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Using microwave technique in the presence of citric acid, selenium nanoparticles (SeNPs) were fabricated. The morphological characteristics revealed that the spherical SeNPs with diameters ranging from 10.5 to 20 nm aggregated spherical shapes with sizes ranging from 0.67 to 0.83 mm. Moreover, the antioxidant efficacy was assessed by the DPPH radical scavenging test, which depicted that green-prepared nanoparticle at a 106.3 mg/mL dosage had the maximum scavenging capacity (301.1 ± 11.42 mg/g). Otherwise, with nanoparticle concentrations of 500 mg/ml, in vitro cell viability of SeNPs through human breast cancer MCF-7 cell lines was reduced to 61.2 ± 2.2% after 1 day of exposure. The antibacterial activity was tested against G-negative Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli ( E. coli ), G-positive bacteria Bacillus subtilis (B. subtilis) , and Staphylococcus aureus ( S. aureus ), which demonstrated that SeNPs had little activity against S. aureus . Still, it had the highest activity against E. coli , with a zone of inhibition (ZOI) of 25.2 ± 1.5 mm compared to 16.0 ± 0.6 mm for the standard antibiotic. Most notably, biogenic SeNPs have anticoagulant activities using activated partial thromboplastin time (aPTT) assessment. Based on previous findings, SeNPs can be used in medical aid and their cell viability, antioxidant, anticoagulant, and effects on bacteria.

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“…PDA is also very efficient in complexing several metal ions and the effect of the presence of metals on the AOX properties has been recently reviewed [ 88 ]. Similarly, the general effect of surface functionalization on the ROS-scavenging ability has been discussed [ 89 ].…”

Section: Aox Properties Of Melanin Npmentioning

confidence: 99%

Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents

et al. 2023

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Nanosized antioxidants are highly advantageous in terms of versatility and pharmacokinetics, with respect to conventional molecular ones. Melanin-like materials, artificial species inspired by natural melanin, combine recognized antioxidant (AOX) activity with a unique versatility of preparation and modification. Due to this versatility and documented biocompatibility, artificial melanin has been incorporated into a variety of nanoparticles (NP) in order to give new platforms for nanomedicine with enhanced AOX activity. In this review article, we first discuss the chemical mechanisms behind the AOX activity of materials in the context of the inhibition of the radical chain reaction responsible for the peroxidation of biomolecules. We also focus briefly on the AOX properties of melanin-like NP, considering the effect of parameters such as size, preparation methods and surface functionalization on them. Then, we consider the most recent and relevant applications of AOX melanin-like NPs that are able to counteract ferroptosis and be involved in the treatment of important diseases that affect, e.g., the cardiovascular and nervous systems, as well as the kidneys, liver and articulations. A specific section will be dedicated to cancer treatment, since the role of melanin in this context is still very debated. Finally, we propose future strategies in AOX development for a better chemical understanding of melanin-like materials. In particular, the composition and structure of these materials are still debated, and they present a high level of variability. Thus, a better understanding of the mechanism behind the interaction of melanin-like nanostructures with different radicals and highly reactive species would be highly advantageous for the design of more effective and specific AOX nano-agents.

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Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism

Cited by 29 publications

References 128 publications

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Citric acid-mediated green synthesis of selenium nanoparticles: antioxidant, antimicrobial, and anticoagulant potential applications

Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents

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