Recent progress of national banking project on homozygous
            <scp>HLA</scp>
            ‐typed induced pluripotent stem cells in
            <scp>S</scp>
            outh
            <scp>K</scp>
            orea

Rim, Yeri Alice; Park, Narae; Nam, Yoonho; Ham, Dong-Sik; Kim, Jiwon; Ha, Hye-Yeong; Jung, Ji‐Won; Jung, Seung Min; Baek, In‐Cheol; Kim, Su-Yeon; Kim, Tai‐Gyu; Song, Jihwan; Lee, Jennifer; Park, Sung-Hwan; Chung, Nack‐Gyun; Yoon, Kun‐Ho; Ju, Ji Hyeon

doi:10.1002/term.2578

Cited by 41 publications

(39 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, clinical-grade iPSC haplobanks are already available in South Korea and Japan (16,19,20,26) and similar initiatives are being undertaken in other countries such as Australia (27). The effectiveness of the approach will come from a global collaborative to share haplolines and this implies an effort to standardize the production and quality control by the different banks (28,29).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Álvarez-Palomo

Garcia-Martínez

Gayoso

et al. 2020

Preprint

View full text Add to dashboard Cite

Background iPSC (Induced Pluripotent Stem Cells) banks of iPSC lines with homozygous HLA (Human Leukocyte Antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation of iPSC derived cell therapies. Cord blood banks offer an extensive source of HLA-typed cells suitable for reprogramming to iPSC. Several initiatives worldwide have been undertaken to create national and international iPSC haplobanks that match a significant part of a population. Methods To create an iPSC haplobank that serves the Spanish population (IPS-PANIA), we have searched the Spanish Bone Marrow Donor Registry (REDMO) to identify the most frequently estimated haplotypes. From the top ten donors identified, we estimated the population coverage using the criteria of zero mismatches in HLA-A, -B and -DRB1 with different stringencies: high resolution, low resolution and beneficial mismatch. Results We have calculated that ten cord blood units from homozygous donors stored at the Spanish cord blood banks can provide a HLA-A, HLA-B and HLA-DRB1 matching for 28,23% of the population. Conclusion We confirm the feasibility of using banked cord blood units to create an iPSC haplobank that will cover a significant percentage of the Spanish and international population for future advanced therapy replacement strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Other studies have calculated the coverage of haplobanks for the UK population (15), South Korea (16), China (17) and the U.S. (18). iPSC haplobanks created from cord blood and peripheral blood donors are already a reality in South Korea and Japan (16,19,20).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Álvarez-Palomo

Garcia-Martínez

Gayoso

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In this previous study, chondrogenic markers were expressed in chondrogenic pellets, and the level of ECM was as high as that observed with MSCs. In our previous study, we established 13 CBMC‐hiPSCs that have homozygous human leukocyte antigen types in the good manufacturing practice facility (Rim et al, ). These cells are the first human leukocyte antigen‐homozygous hiPSC lines that were developed as a national cell banking cell source.…”

Section: Discussionmentioning

confidence: 99%

Repair potential of nonsurgically delivered induced pluripotent stem cell-derived chondrocytes in a rat osteochondral defect model

Rim

Nam

Park

et al. 2018

J Tissue Eng Regen Med

Self Cite

View full text Add to dashboard Cite

Human induced pluripotent stem cells (hiPSCs) are thought to be an alternative cell source for future regenerative medicine. hiPSCs may allow unlimited production of cell types that have low turnover rates and are difficult to obtain such as autologous chondrocytes. In this study, we generated hiPSC-derived chondrogenic pellets, and chondrocytes were isolated. To confirm the curative effects, chondrogenic pellets and isolated chondrocytes were transplanted into rat joints with osteochondral defects. Isolated hiPSC-derived chondrocytes were delivered in the defect by a single intra-articular injection. The generated hiPSC-derived chondrogenic pellets had increased chondrogenic marker expression and accumulated extracellular matrix proteins. Chondrocytes were successfully isolated from the pellets. Alcian blue staining and collagen type II were detected in the cells. Chondrogenic marker expression was also increased in the isolated cells. Transplanted chondrogenic pellets and chondrocytes both had curative effects in the osteochondral defect rat model. Detection of human proteins in the joints proved that the cells were successfully delivered into the defect. Chondrogenic pellets or chondrocytes generated from hiPSCs have potential as regenerative medicine for cartilage recovery or regeneration. Chondrocytes isolated from hiPSC-derived chondrogenic pellets had curative effects in damaged cartilage. Injectable hiPSC-derived chondrocytes show the possibility of noninvasive delivery of regenerative medicine for cartilage recovery.

show abstract

“…Cord blood mononuclear cell (CBMC)-derived induced pluripotent stem cells (iPSCs) were established and characterized as described previously [28]. In our previous study, we established 13 CBMC-derived iPSC cell lines, characterized by high pluripotency and normal karyotypes.…”

Section: Cell Culturementioning

confidence: 99%

Exacerbation of symptomatic arthritis by cigarette smoke in experimental arthritis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Introduction Epidemiologically, cigarette smoking is a well-known risk factor for the pathogenesis of rheumatoid arthritis (RA). However, there has been few plausible explanations why cigarette smoking aggravated RA. We investigated the causal effect of smoking in experimental model of arthritis development. Methods During induction of experimental arthritis with collagen challenge, mice were exposed to a smoking environment with 3R4F cigarettes. Generated smoke was delivered to mice through a nose-only exposure chamber (ISO standard 3308). Human cartilage pellet was challenged by cigarette smoke extract to identify citrullinating potential in vitro. Results Cigarette smoke exacerbated arthritis in a collagen-induced arthritis (CIA) model. Exposure to smoke accelerated the onset of arthritis by 2 weeks compared to the conventional model without smoke. Citrullination of lung tissue as well as tarsal joints were revealed in smokeaggravated CIA mice. Interestingly, tracheal cartilage was a core organ regarding intensity and area size of citrullination. The trachea might be an interesting organ in viewpoint of sharing cartilage with joint and direct smoke exposure. Anti-CCP antibodies were barely detected in the serum of CIA mice, they were significantly elevated in cigarette smoke group. Citrullinated antigens were increased in the serum of smoke-exposed mice. Lastly, a cigarette smoke extract enhanced human cartilage citrullination in vitro. Conclusions Missing link of arthritic mechanism between smoke and RA could be partially explained by tracheal citrullination. To control tracheal cartilage citrullination may be beneficial for

show abstract

Recent progress of national banking project on homozygous HLA ‐typed induced pluripotent stem cells in S outh K orea

Cited by 41 publications

References 15 publications

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Repair potential of nonsurgically delivered induced pluripotent stem cell-derived chondrocytes in a rat osteochondral defect model

Exacerbation of symptomatic arthritis by cigarette smoke in experimental arthritis

Contact Info

Product

Resources

About