Recent progress of microfluidic reactors for biomedical applications

Shi, Huanhuan; Nie, Kaixuan; Dong, Bo; Long, Mengqiu; Xu, Hui; Liu, Zhengchun

doi:10.1016/j.cej.2018.12.104

Cited by 148 publications

(58 citation statements)

References 129 publications

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“…Because of that, it is possible now for a real-time monitoring of biomarker labeling, drug's mechanism of action, clinical pathology, tissue, and organ physiology just within a microscale portable device and without any victim animal [106,107]. In addition to that, the microfluidic probe has been also employed for a single-cell pharmacological analysis which is remarkable [108,109]. The schematic image of the organ-on-chip device including injection point for A and B chemicals, mixer, reaction place (reactor), separator, detector, and process waste stream is shown in Figure 5.…”

Section: Where Is the Microfluidics Today?mentioning

confidence: 99%

Microfluidics Era in Chemistry Field: A Review

et al. 2019

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By miniaturizing the reactor dimension, microfluidic devices are attracting world attention and starting the microfluidic era, especially in the chemistry field because they offer great advantages such as rapid processes, small amount of the required reagents, low risk, ease and accurate control, portable and possibility of online monitoring. Because of that, microfluidic devices have been massively investigated and applied for the real application of human life. This review summarizes the up-to-date microfluidic research works including continuous-flow, droplet-based, open-system, paper-based and digital microfluidic devices. The brief fabrication technique of those microfluidic devices, as well as their potential application for particles separation, solvent extraction, nanoparticle fabrication, qualitative and quantitative analysis, environmental monitoring, drug delivery, biochemical assay and so on, are discussed. Recent perspectives of the microfluidics as a lab-on-chip or micro total analysis system device and organ-on-chip are also introduced.

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Section: Where Is the Microfluidics Today?mentioning

confidence: 99%

Microfluidics Era in Chemistry Field: A Review

et al. 2019

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“…In the past decade, micro-and nanoscale devices have stimulated considerable attention [1][2][3] due to their promising applications in sensing, tracking, decontamination, and biomedical areas. [4,5] In particular, micro/nanomotors with desirable dimensions, promising potential of active targeting abilities as well as autonomous or semi-autonomous mobility in a predesigned direction with tuned velocity have paved the way for designing multifunctional drug delivery systems. [6,7] Initially, a wide range of technological developments started from the synthetic micro/nanomotors and various types of such micro/nanomotors have been successfully fabricated, such as microtubes, [8] nanowires, [9] Janus micro/nanomotors, [10,11] and helical micro/nanomotors.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Motion Control of Micro/Nanomotors

Yang

Zhong

et al. 2020

Advanced Intelligent Systems

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Micro/nanomotors are able to convert energy in different forms into propulsion and movement with predesigned directions and velocities, enabling them to be self‐propelled carriers and vehicles for the delivery of active pharmaceutical ingredients and other biomedical cargos to the target sites such as tumors. However, the inadequate energy and noncontrollable moving directions remain the grand challenges for their promising applications. Recently, an increasing attention has been paid to these issues and numerous reported researches have focused to design and develop more efficient and precisely controllable micro/nanomotors with different methods. This review aims to summarize those studies and to introduce newly developed micro/nanomotors including synthetic micro/nanomotors and biohybrid motors, discussing the control mechanisms as well as advantages and limitations thereof. Conclusions and future perspectives are also provided in brief.

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“…In fact, the ability to generate stable linear [7] or nonlinear spatial chemical gradient profiles within microfluidics has been adapted extensively for analysis [8]. Past research studies have shown that a device that can generate spatially and temporally controlled gradients is regarded as a robust and powerful method to investigate migratory cells [9][10][11][12], drug screening [13,14], oil production screening from microalgae [15], nucleation and growth of crystals [16], and wound healing [17] under a variety of conditions.…”

Section: Introductionmentioning

confidence: 99%

A Microfluidic Concentration Gradient Maker with Tunable Concentration Profiles by Changing Feed Flow Rate Ratios

Zhang

Meng

et al. 2020

Micromachines

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Microfluidic chips—in which chemical or biological fluid samples are mixed into linear or nonlinear concentration distribution profiles—have generated enormous enthusiasm of their ability to develop patterns for drug release and their potential toxicology applications. These microfluidic devices have untapped potential for varying concentration patterns by the use of one single device or by easy-to-operate procedures. To address this challenge, we developed a soft-lithography-fabricated microfluidic platform that enabled one single device to be used as a concentration maker, which could generate linear, bell-type, or even S-type concentration profiles by tuning the feed flow rate ratios of each independent inlet. Here, we present an FFRR (feed flow rate ratio) adjustment approach to generate tens of types of concentration gradient profiles with one single device. To demonstrate the advantages of this approach, we used a Christmas-tree-like microfluidic chip as the demo. Its performance was analyzed using numerical simulation models and experimental investigations, and it showed an excellent time response (~10 s). With on-demand flow rate ratios, the FFRR microfluidic device could be used for many lab-on-a-chip applications where flexible concentration profiles are required for analysis.

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Recent progress of microfluidic reactors for biomedical applications

Cited by 148 publications

References 129 publications

Microfluidics Era in Chemistry Field: A Review

Microfluidics Era in Chemistry Field: A Review

Recent Advances in Motion Control of Micro/Nanomotors

A Microfluidic Concentration Gradient Maker with Tunable Concentration Profiles by Changing Feed Flow Rate Ratios

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