Recent progress of HIMAC for sophisticated heavy-ion cancer radiotherapy

Noda, K.; Furukawa, Takuji; Fujimoto, T.; Hara, Yusuke; Inaniwa, Taku; Iwata, Y.; Katagiri, Ken; Kanematsu, Nobuyuki; Mizushima, Kota; Miyoshi, Tomohiro; Mori, Shinichiro; Murakami, Takeshi; Sano, Y.; Sato, Shinji; Shirai, Tomoyuki; Takada, E.; Takei, Yasuhiko; Yonai, Shunsuke

doi:10.1016/j.nimb.2013.12.036

Cited by 17 publications

(8 citation statements)

References 14 publications

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“…57 The PCR utilizes advanced technologies such as high-speed scanning magnet (100 mm ms 21 in horizontal and 50 mm ms 21 in vertical directions), extended flat-top operation of the synchrotron and the spill control system designed to deliver an intensitymodulated beam. 75 The simulation study showed that in case of liver tumours, gated rescanning is able to ensure good dose conformity and maximal sparing of healthy tissues on the condition that an odd number of at least seven PCRs are performed. 22 Another research demonstrated that multiple PCRs with amplitude-based gating allows providing clinically acceptable dose distributions for the lung and liver moving tumours, even in the presence of irregular breathing.…”

Section: Irradiation Of Moving Targetsmentioning

confidence: 97%

“…69 The technique, called phase-controlled rescanning (PCR), carries out repainting of all spots of a single layer within the gating window. 57,75 When one slice is fully irradiated by the pencil beam (with Bragg peak spread-out of 3 mm by the mini ridge filter), the energy is changed and the rescanning is performed for the next layer. 26,57 The process is repeated (11 synchrotron energy steps are available) until all target cross-sections obtain the prescribed dose.…”

Section: Irradiation Of Moving Targetsmentioning

confidence: 99%

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Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Kubiak¹

2016

BJR

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Particle therapy of moving targets is still a great challenge. The motion of organs situated in the thorax and abdomen strongly affects the precision of proton and carbon ion radiotherapy. The motion is responsible for not only the dislocation of the tumour but also the alterations in the internal density along the beam path, which influence the range of particle beams. Furthermore, in case of pencil beam scanning, there is an interference between the target movement and dynamic beam delivery. This review presents the strategies for tumour motion monitoring and moving target irradiation in the context of hadron therapy. Methods enabling the direct determination of tumour position (fluoroscopic imaging of implanted radio-opaque fiducial markers, electromagnetic detection of inserted transponders and ultrasonic tumour localization systems) are presented. Attention is also drawn to the techniques which use external surrogate motion for an indirect estimation of target displacement during irradiation. The role of respiratory-correlated CT [four-dimensional CT (4DCT)] in the determination of motion pattern prior to the particle treatment is also considered. An essential part of the article is the review of the main approaches to moving target irradiation in hadron therapy: gating, rescanning (repainting), gated rescanning and tumour tracking. The advantages, drawbacks and development trends of these methods are discussed. The new accelerators, called "cyclinacs", are presented, because their application to particle therapy will allow making a breakthrough in the 4D spot scanning treatment of moving organs.

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Section: Irradiation Of Moving Targetsmentioning

confidence: 97%

Section: Irradiation Of Moving Targetsmentioning

confidence: 99%

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Kubiak¹

2016

BJR

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“…A compact rotating gantry with a carbon ion pencil beam capable of three-dimensional (3D) scanning has been developed for advanced cancer radiotherapy to provide a higher contrast dose distribution . A 3D dosimeter for heavy ion beam irradiation is therefore needed to verify complex dose distributions in tissue-equivalent material .…”

Section: Introductionmentioning

confidence: 99%

Organic-Gelatin-Free Nanocomposite Fricke Gel Dosimeter

et al. 2017

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We report a nanocomposite Fricke gel (NC-FG) dosimeter prepared using only Fe and nanoclay in water, without any organic gelling agents. This dosimeter gels due to its thixotropic properties and exhibits linear energy transfer (LET)-independent radiological properties under carbon ion beam irradiation. The radiation sensitivity of this dosimeter was 1.8 [s kGy], which is three times higher than that reported previously (0.6 [s kGy]) for a similar dosimeter containing gelatin. The Fe yield was determined to be 0.19 μmol/J by evaluating the difference in spin-lattice relaxivity between Fe and Fe. A further increase in the radiation sensitivity was observed upon addition of the hydrated electron scavenger NO, suggesting the reduction of Fe by a hydrated electron. LET-dependent variations of the contributions of OH radicals and hydrated electrons compensate each other in the oxidation yield of NC-FG. This is the main mechanism of the suppression of LET effects in the Bragg peak compared to conventional Fricke dosimeters. The radiation-induced oxidation yield G(Fe) can be described by the stoichiometric equation {G(Fe) = G(OH) - G(e) + 2G(HO) + G(H)} with the reported LET dependence of the primary yield of water decomposition radicals. The calculated results are in approximate agreement with the absolute value of the experimental oxidation yield of NC-FG. The effects of the addition of small amounts of radical scavengers (nitrate, selenate, or cadmium) are also evaluated. The sensitivity was divided into two types, and influences of intermediate radicals after scavenging reaction are indicated.

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“…This requires the development of ion beam dosimeters that satisfy characteristic dosimetric properties (9). Thus, there is increasing demand for the dosimetry of charged particle beams because they are increasingly used for diagnostic and therapeutic purposes (4,5,10). Commonly used dosimeters such as LiF:Cu,Mg,P and CaSO 4 :Dy are not standardized for use in ion dosimetry and there is the opportunity to develop new materials tailored for ion dosimetry.…”

Section: Introductionmentioning

confidence: 99%

Comparison of thermoluminescence characteristics in γ‐ray and C⁵⁺ ion beam‐irradiated LiCaAlF₆:Ce phosphor

Yerpude

Dhoble²,

Lochab

et al. 2016

Luminescence

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We compare the thermoluminescence (TL) behavior of Ce(3+) ion-activated LiCaAlF6 exposed to γ-rays and a carbon ion beam. The reported phosphor is synthesized using an in-house precipitation method with varying concentrations of activator ion and is characterized by X-ray diffraction (XRD) and TL. Rietveld refinement is performed to study the structural statistics. The TL glow curve consists of a prominent glow peak at 232°C with three shoulders at 115, 159 and 333°C when exposed to γ-rays from a (60) Co source. When exposed to a C(5+) ion beam, the TL glow curve consists of five peaks with peak temperatures near 156, 221, 250, 287 and 330°C, and is found to vary slightly with changing fluence. Glow curve convolution deconvolution (GCCD) functions are applied to the TL curves for complete analysis of the glow curve structure and TL traps. The order of kinetics (b), activation energy (E) and frequency factor are determined using Chen's peak shape method and theoretical curves are drawn using GCCD functions. A track interaction model (TIM) is used to explain the sublinearity/saturation at higher fluences. Ion beam parameters are analyzed using Monte-Carlo simulation-based SRIM-2013 code. Copyright © 2016 John Wiley & Sons, Ltd.

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Recent progress of HIMAC for sophisticated heavy-ion cancer radiotherapy

Cited by 17 publications

References 14 publications

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Organic-Gelatin-Free Nanocomposite Fricke Gel Dosimeter

Comparison of thermoluminescence characteristics in γ‐ray and C⁵⁺ ion beam‐irradiated LiCaAlF₆:Ce phosphor

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Recent progress of HIMAC for sophisticated heavy-ion cancer radiotherapy

Cited by 17 publications

References 14 publications

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Organic-Gelatin-Free Nanocomposite Fricke Gel Dosimeter

Comparison of thermoluminescence characteristics in γ‐ray and C5+ ion beam‐irradiated LiCaAlF6:Ce phosphor

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Product

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Comparison of thermoluminescence characteristics in γ‐ray and C⁵⁺ ion beam‐irradiated LiCaAlF₆:Ce phosphor