Recent Progress of Electrospun Herbal Medicine Nanofibers

Liu, Huan; Bai, Yubin; Huang, Chang; Wang, Ying; Ji, Yuexin; Du, Yutong; Xu, Lin; Yu, Deng‐Guang; Bligh, S. W. Annie

doi:10.3390/biom13010184

Cited by 46 publications

(19 citation statements)

References 274 publications

(353 reference statements)

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“…A reasonable selection of a drug carrier must meet several conditions, which at a minimum include good compatibility, manipulation of the drug release behaviors, and good processability ( Hameed et al, 2022 ; Ge et al, 2023 ; Liu et al, 2023 ). PVP has a series of products and has a broad application in a wide variety of fields.…”

Section: Resultsmentioning

confidence: 99%

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Liu

Dai

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: As an interdisciplinary field, drug delivery relies on the developments of modern science and technology. Correspondingly, how to upgrade the traditional dosage forms for a more efficacious, safer, and convenient drug delivery poses a continuous challenge to researchers.Methods, results and discussion: In this study, a proof-of-concept demonstration was conducted to convert a popular traditional liquid dosage form (a commercial oral compound solution prepared from an intermediate licorice fluidextract) into a solid dosage form. The oral commercial solution was successfully encapsulated into the core–shell nanohybrids, and the ethanol in the oral solution was removed. The SEM and TEM evaluations showed that the prepared nanofibers had linear morphologies without any discerned spindles or beads and an obvious core–shell nanostructure. The FTIR and XRD results verified that the active ingredients in the commercial solution were compatible with the polymeric matrices and were presented in the core section in an amorphous state. Three different types of methods were developed, and the fast dissolution of the electrospun core–shell nanofibers was verified.Conclusion: Coaxial electrospinning can act as a nano pharmaceutical technique to upgrade the traditional oral solution into fast-dissolving solid drug delivery films to retain the advantages of the liquid dosage forms and the solid dosage forms.

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Section: Resultsmentioning

confidence: 99%

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Liu

Dai

et al. 2023

Front. Bioeng. Biotechnol.

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“…A series of experimental variables, including the electrostatic field force [ 10 , 11 ], polymer parameters [ 12 ], solvent [ 13 ], spinneret [ 14 , 15 , 16 ], environment humidity [ 17 ], and temperature [ 18 ], have an impact on the morphology and structure of electrospun nanofibers. Coaxial and triaxial multifluid electrospinning processes have also been reported in recent years [ 19 , 20 , 21 ]. In this field, polymer fibers are functionalized by adding active ingredients in a mixed electrospinning process.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang

Cao

et al. 2023

Polymers

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Electrospun porous nanofibers have gained a lot of interest recently in various fields because of their adjustable porous structure, high specific surface area, and large number of active sites, which can further enhance the performance of materials. This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. Firstly, the polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning, namely the template method and phase separation method, are introduced. Secondly, recent applications of electrospun porous nanofibers in air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound and wave absorption, flame retardant, and heat insulation are reviewed. Finally, the challenges and possible research directions for the future study of electrospun porous nanofibers are discussed.

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“…Multifluid spinning improves the efficiency of preparing functional nanofibers, allowing for one-step preparation of complex functional nanofibers [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. A series of spinnerets with multistage structures, which could be used to implement multi-fluid electrospinning processes for preparing complex biomedical nanostructures, were reported [ 40 , 41 , 42 , 43 , 44 , 45 ]. Core–sheath nanofibers are nanomaterials with a hierarchical structure that can be customized for specific functions [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Yang

Kang

et al. 2023

Sensors

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This study presents a glucose biosensor based on electrospun core–sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely of core–sheath nanofibers fabricated using a modified coaxial electrospinning process. Film F2 was a double-layer hybrid film fabricated through a sequential electrospinning and blending process. The bottom layer of F2 comprised core–sheath nanofibers fabricated using a modified process, in which pure polymethacrylate type A (Eudragit L100) was used as the core section and water-soluble lignin (WSL) and phenol were loaded as the sheath section. The top layer of F2 contained glucose oxidase (GOx) and gold nanoparticles, which were distributed throughout the polyvinylpyrrolidone K90 (PVP K90) nanofibers through a single-fluid blending electrospinning process. The study investigated the sequential electrospinning process in detail. The experimental results demonstrated that the F2 hybrid film had a higher degradation efficiency of β-D-glucose than F1, reaching a maximum of over 70% after 12 h within the concentration range of 10–40 mmol/L. The hybrid film F2 is used for colorimetric sensing of β-D-glucose in the range of 1–15 mmol/L. The solution exhibited a color that deepened gradually with an increase in β-D-glucose concentration. Electrospinning is flexible in creating structures for bio-cascade reactions, and the double-layer hybrid film can provide a simple template for developing other sensing nanomaterials.

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Recent Progress of Electrospun Herbal Medicine Nanofibers

Cited by 46 publications

References 274 publications

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

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