Recent Progress in Ti-Based Metallic Glasses for Application as Biomaterials

Abstract

Ti-based bulk metallic glasses are of great interest in biomedical applications due to their high corrosion resistance, excellent mechanical properties and good biocompatibility. This article reviews recent progress in the development of Ti-based metallic glasses for the application as biomaterials. Ti-based (TiZrCuPd, TiZrCuPdSn, and TiZrCuPdNb) bulk metallic glasses without toxic and allergic elements have been developed. These glassy alloys exhibited high glass-forming ability, high strength, large plasticity, good corrosion resistance and excellent biocompatibility, which open possibilities to create Ti-based metallic glass implants. Using a spark plasma sintering process, large-size Ti-based bulk metallic glasses and the composites with hydroxyapatite, as well as porous glassy alloys having approximate Young's modulus with that of bone were developed.

Corrosion of Metallic Biomaterials: A Review

“…Among these, some contain nickel and/or beryllium and will not be mentioned here, because I do not find them of real potential use. Others include the Ti–Zr–Cu–Pd, Ti–Zr–Cu–Pd–Sn, Ti–Zr–Hf–Cu–Ni–Si–Sn, Ti–Zr–(Ta/Pd)–Si, Ti–Zr–Si, Ti–Si, Ti–Nb–Si and Ti–Zr–Nb–Si systems [224,226,227,228,229,230,231,232,233,234,235]. Ti-based BMGs have fairly low Young’s modulus (80–120 GPa), high fracture strength (1700–2500 MPa), low density, excellent specific strength and high wear resistance [224].…”

Designing new biocompatible glass‐forming Ti75‐xZr10NbxSi15 (x = 0, 15) alloys: corrosion, passivity, and apatite formation

“…22,23 The first corrosion investigations of VM-Cubased bulk metallic glasses such as in the Ti-Zr-Cu-Pd system in simulated body fluid revealed the presence of large fractions of Cu in the alloy (30 at %) as being critical for the initiation of pronounced pitting events. 10,14,24 Such a critical role of Cu for the pitting susceptibility of metallic glasses was recently confirmed in a study by Lin et al 3 who compared the electrochemical behavior of different metallic glasses on Zr-, Ti-, and Ta-base in Hanks solution.…”

“…[8][9][10][11][12][13] Typical alloy systems with bulk glass-forming ability are for example Ti 40 Zr 10 Cu 36 Pd 14 with max. cast rod diameter of 6 mm 14 or Ti 40 Zr 25 Cu 12 Ni 3 Be 20 with max. cast rod diameter of 14 mm.…”

“…Those corrosion events are often due to the presence of cast defects (e.g., crystalline inclusions, pores) or of defects generated by mechanical processing (e.g., shear‐bands) that cause a local break down of passivity . The first corrosion investigations of VM‐Cu‐based bulk metallic glasses such as in the Ti‐Zr‐Cu‐Pd system in simulated body fluid revealed the presence of large fractions of Cu in the alloy (≥30 at %) as being critical for the initiation of pronounced pitting events . Such a critical role of Cu for the pitting susceptibility of metallic glasses was recently confirmed in a study by Lin et al who compared the electrochemical behavior of different metallic glasses on Zr‐, Ti‐, and Ta‐base in Hanks solution.…”

Biodegradable Mg–Zn–Ca-Based Metallic Glasses

“…There are numerous comprehensive and systemic reviews on various MGs for engineering materials application [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. There are also some reviews on Fe-, Ti-, Zr-, Mg-, and Ca-based MGs, which were developed for biomedical purposes [ 15 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. In particular, biodegradable Mg-based MGs are very promising candidates for temporary biomedical implants, such as cardiovascular stents, bone screws, and plates.…”