Recent progress in the detection and treatment of atherosclerosis by nanoparticles

Dysfunctional Vascular Endothelium as a Driver of Atherosclerosis: Emerging Insights Into Pathogenesis and Treatment

“…Advances in the development of nanoparticles (on a scale of <0.1 μm) have likewise afforded new opportunities for anti-atherosclerotic therapies that resolve endothelial dysfunction ( Flores et al, 2019 ; Marchio et al, 2019 ; Chen L. et al, 2020 ). Vascular nanotherapies have been broadly classified as those which resolve inflammation and dysfunction in efferocytosis, limit plaque neovascularization and neointimal growth, modulate lipid metabolism, and decrease thrombosis ( Flores et al, 2019 ).…”

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

“…Delivering drugs to intimal macrophage/foam cells to suppress plaque inflammation is a potential intervention strategy for atherosclerosis therapy [ [7] , [8] , [9] ]. Nanoparticles have been widely utilized as drug and gene carriers for atherosclerosis therapy [ [10] , [11] , [12] ]. Nanoparticles must penetrate a thick fibrous cap—mainly composed of vascular smooth muscle cells and collagenous fibers—through leaky vasculature and subsequent inflammatory cell-mediated sequestration (ELVIS) effect [ 13 , 14 ] before they reach pathological macrophage/foam cells [ 15 , 16 ].…”

Green and efficient piezocatalytic hydrogen production achieved by modifying SrBi4Ti4O15 with CdSe

“…The SrBi 4 Ti 4 O 15 nanosheets (SBTO NSs) with a unique layered structure can be prepared via a facile hydrothermal method. 20 In comparison to SBTO obtained using alternative preparation techniques, the hydrothermally synthesized SBTO NSs offer several advantages, 21 rendering them an ideal material for piezoelectric catalytic reactions. [22][23][24][25] However, even in the case of SBTO NSs prepared via a hydrothermal method, the migration of interface charge carriers remains relatively weak, leading to diminished surface reactivity.…”