Recent progress in the applications of gold-based nanoparticles towards tumor-targeted imaging and therapy

Abstract

We summarize the latest developments of gold nanomaterials in imaging and combined therapy as well as prospects for the future application of gold-based theranostic nanoplatforms.

Computational Nanomaterials Design: towards the Realization of Nanoparticle use in Radiotherapy Case Study 2: Adsorption states of At on Au (111) Surface

“…Gold and, by extension, gold nanoparticles (AuNPs) have been used in applications such as electronics, catalysis, and biomedicine due to the many advantageous properties that they possess [11][12][13][14][15][16][17][18]. Synthesis of AuNPs can be tailored depending on the desired uses, and AuNPs are also deemed to be suitable for biomedical applications due to their low toxicity and ability to penetrate deep into cells [7,9,[16][17][18][19][20][21][22][23]. Many applications for AuNPs have been developed including as drug carriers, tumor imaging, hyperthermia, etc [16][17][18].…”

“…Synthesis of AuNPs can be tailored depending on the desired uses, and AuNPs are also deemed to be suitable for biomedical applications due to their low toxicity and ability to penetrate deep into cells [7,9,[16][17][18][19][20][21][22][23]. Many applications for AuNPs have been developed including as drug carriers, tumor imaging, hyperthermia, etc [16][17][18]. AuNPs can also be used to carry out radiotherapy by being labeled with radioactive materials such as 225 Ac, 227 Th, and 125 I among others [10, 24,25].…”

Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters

“…Spherical Au nanoparticles have been widely utilized in cancer treatment, mainly thanks to their unique physicochemical properties, their excellent biocompatibility, and particularly their characteristic surface plasmon resonance absorbance with specific wavelengths [ 19 , 20 ]. Spherical Au nanoparticles can be applied for cancer treatment in several ways such as photothermal therapy, radiotherapy, tumor imaging, and serving as drug delivery systems [ 21 , 22 , 23 , 24 , 25 , 26 ].…”

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma

“…Combining noble metal-based nanotechnology with diagnostic methods and therapies (from traditional radiotherapy to emerging immunotherapy) has improved the accuracy and efficiency of cancer diagnosis and treatment ( Jiao et al, 2016 ; Mohammadniaei et al, 2019 ; Zhan et al, 2021 ). Gold NPs are the most frequently utilized noble metal NPs in tumor diagnosis and treatment due to their unique radiosensitizing properties, good biocompatibility, and relatively low toxicity ( Boisselier and Astruc, 2009 ; Kovács et al, 2022 ; Li et al, 2022 ). Studies have also shown that GNPs may possess certain targeting properties, as demonstrated by the fact that GNPs selectively act on heparin-binding proteins, such as EGFR and VEGFR-2 ( Mukherjee et al, 2005 ; Huang et al, 2021 ; Zhao et al, 2022 ).…”