Recent progress in quantum dot based sensors

Cui, Lei; He, Xiao‐Peng; Chen, Guorong

doi:10.1039/c5ra01950h

Cited by 84 publications

(38 citation statements)

References 131 publications

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“…Because of the presence of both AuNP and GO, the Raman signals of the dyes were drastically enhanced, leading to simultaneous ultrasensitive detection of two specific DNAs with excitation from a single light source . Quantum dots (QDs), semiconductor nanomaterials that show quantum mechanical properties, are another class of prevailing nanoparticles for the fabrication of biosensors for both in vitro and in vivo applications . QDs with different emission colors were used to conjugate with two ssDNAs that target two genes of a highly pathogenic bacterium.…”

Section: Photoluminescence Architectures: Simple Construction and DIVmentioning

confidence: 99%

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides

Tian

2015

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Ever since the discovery of graphene, increasing efforts have been devoted to the use of this stellar material as well as the development of other graphene-like materials such as thin-layer transition metal dichalcogenides and oxides (TMD/Os) for a variety of applications. Because of their large surface area and unique optical properties, these two-dimensional materials with a size ranging from the micro- to the nanoscale have been employed as the substrate to construct photoluminescence architectures for disease diagnosis as well as theranostics. These architectures are built through the simple self-assembly of labeled biomolecular probes with the substrate material, leading to signal quenching. Upon the specific interaction of the architecture with a target biomarker, the signal can be spontaneously restored in a reversible manner. Meanwhile, by co-loading therapeutic agents and employing the inherent photo-thermal properties of the material substrates, a combined disease imaging and therapy (theranostics) can be achieved. This review highlights the latest advances in the construction and application of graphene and TMD/O based thin-layer material composites for single-target and multiplexed detection of a variety of biomarkers and theranostics. These versatile material architectures, owing to their ease in preparation, low cost and flexibility in functionalization, provide promising tools for both basic biochemical research and clinical applications.

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Section: Photoluminescence Architectures: Simple Construction and DIVmentioning

confidence: 99%

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides

Tian

2015

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“…Our previous studies have showed that QDs have unique optical and electronic properties such as size-tunable light emission, superior signal brightness, resistance to photobleaching and simultaneous excitation of multiple fluorescence colors. [25][26][27] QDs have gained broad application in many areas of biology. 28 The versatile properties of QDs have allowed investigators to conduct biological studies with extended spatiotemporal capabilities.…”

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Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells

Peng

Liu

Yang

et al. 2017

IJN

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Purpose Semiconductor quantum dots (QDs) are a promising alternative to organic fluorescent dyes for multiplexed molecular imaging of cancer stroma, which have great advantages in holistically analyzing the complex interactions among cancer stromal components in situ. Patients and methods A QD probe-based multiplexed spectral molecular imaging method was established for simultaneous imaging. Three tissue microarrays (TMAs) including 184 gastric cancer (GC) tissues were constructed for the study. Multispectral analyses were performed for quantifying stromal biomarkers, such as lysyl oxidase (LOX). The stromal status including infiltrating of immune cells (high density of macrophages), angiogenesis (high density of microvessel density [MVD], low neovessel maturation) and extracellular matrix (ECM) remodeling (low density of type IV collagen, intense expression of matrix metalloproteinase 9 [MMP-9]) was evaluated. Results This study compared the imaging features of the QD probe-based single molecular imaging method, immunohistochemistry, and organic dye-based immunofluorescent methods, and showed the advantages of the QD probe-based multiple molecular imaging method for simultaneously visualizing complex components of cancer stroma. The risk of macrophages in high density, high MVD, low neomicrovessel maturation, MMP-9 expression and low type IV collagen was significantly increased for the expression of LOX. With the advantages of the established QD probe-based multiplexed molecular imaging method, the spatial relationship between LOX and stromal essential events could be simultaneously evaluated histologically. Stromal activation was defined and then evaluated. Survival analysis showed that the stromal activation was correlated with overall survival and disease-free survival ( P <0.001 for all). The expression of LOX was significantly increased in the intense activation subgroup ( P <0.001). Conclusion Quantifying assessment of the stroma indicates that the LOX may be a stromal marker for GC and stromal activation, which is not only responsible for the ECM remodeling morphologically, but also for the formation of invasive properties and recurrence. These results support the possibility to integrate morphological and molecular biomarker information for cancer research by the biomedical application of QDs.

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“…This allows for a considerable reduction in manufacturing expenditures and is therefore very attractive for industrial purposes. Other than their emissive properties, they can also be used for a variety of other applications like in sensing devices, photovoltaics and more . Thus, colloidal QDs have been actively pursued for both fundamental research and industrial development due to their solution processability and size‐dependent optical properties associated with quantum confinement.…”

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confidence: 99%

The Next Stage in Colloidal Synthesis of Aqueous CdSe Quantum Dots: High Throughput and Intense Emissive Properties

et al. 2019

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Quantum dots (QDs) of CdSe have been produced with high yield using common reagents in water at 150 °C. The QDs thus produced are water compatible, show intense fluorescence emission and have high quantum yields (QYs). Their size can be controlled similarly to the high temperature organometallic method of synthesizing QDs, and these QDs produced in organic solvents at high temperature and the QDs produced in water both show comparable QYs. The great advantage is that a green solvent, water, is used and their separation from the water is very simple. They can be stored dry very easily. Similar to the organic method their size can be controlled by time, producing QDs with distinct fluorescence. The size obtained by TEM for 30, 60 and 90 minutes of reaction is 4.18 nm, 6.7 nm and 8.6 nm, respectively. This parallels the change in the emission wavelength of the QDs produced; green, yellow and orange, respectively. TEM dimensions are very similar to these of DLS (dynamic light scattering). These QDs display the hexagonal wurtzite phase, common for the higher temperature synthesis of QDs in organic solvents, and not the zinc blende phase of CdSe QDs common for the lower temperature water synthesis of QDs. The prepared QDs have shown the same intense emission for over a year after being synthesized.

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Recent progress in quantum dot based sensors

Abstract: Recent progress in quantum dot (QD) based chemo- and biosensors for various applications is summarized.

Cited by 84 publications

References 131 publications

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides

Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides

Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells

The Next Stage in Colloidal Synthesis of Aqueous CdSe Quantum Dots: High Throughput and Intense Emissive Properties

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