The potential biomedical applications of the MNPs nanohybrids coated with mcarboranylphosphinate (1-MNPs) as a theranostic biomaterial for cancer therapy were tested. The cellular uptake and toxicity profile of 1-MNPs from culture media by human brain endothelial cells (hCMEC/D3) and glioblastoma multiform A172 cell line was demonstrated. Prior to testing 1-MNPs' in vitro toxicity, studies of colloidal stability of the 1-MNPs' suspension in different culture media and temperatures were carried out. TEM images and chemical titration confirmed that 1-MNPs penetrate into cells. Additionally, to explore 1-MNPs' potential use in Boron Neutron Capture Therapy (BNCT) for treating cancer locally, the presence of the mcarboranyl coordinated with the MNPs core after uptake was proven by XPS and EELS. Importantly, thermal neutrons irradiation in BNCT reduced by 2.5 the number of cultured glioblastoma cells after 1-MNP treatment, and the systemic administration of 1-MNPs in mice was well tolerated with no major signs of toxicity.
Closely packed hollow spheres connected through pillars to a CdSe quantum dot (QD) core produce channels through which ions navigate. This particular structure is well represented by [CdSe@CarbOPH(O)]@Cl/[N(Caprylyl) Me ] indicating that in the channels between the canopy made by the carboranyl spheres (carboranylphosphinate, CarbOPH(O)) and the CdSe core exist chloride anions. Due to the close packing, the spheres produce openings. These are converted into gates because [N(Caprylyl) Me ] acts as a plug. The [CdSe@CarbOPH(O)]@Cl/assembly is negatively charged because the Cd positive charges are outnumbered by the negative charges due to the Se, the phosphinic acid and, very importantly, the trapped chloride anions, and this negative load is compensated by the cationic surfactant. Here, it is shown that this synergism produces an unprecedented phenomenon, namely, kinetic fluorescence switching. It is observed that the material shines brightly then loses its brightness and, upon the application of kinetic energy, shines back to the maximum power. This process continues for an extended period of time, up to half a year, at least. This new type of architecture in QDs is named as core-canopy QDs. In this case, this study demonstrates one property, the kinetic fluorescence switching, as a consequence of the trapping of Cl in the QDs channels, but other properties can be envisaged with the judicious choice of the anions or even the pillar connecting the hollow sphere with the ground.
Lipoleiomyoma of the uterus is a rare variant of leiomyoma, and lipoleiomyoma of the broad ligament is still rarer, with only a handful of cases being reported. The present case was a perimenopausal woman who presented with a huge lower abdominal mass. Ultrasonography and computed tomography showed a heterogeneous solid mass in the left adnexa. The histopathological findings confirmed the nature of the lesions as a benign lipoleiomyoma with dermoid cyst of the left ovary and its other associated benign lesions, were the interesting features seen in this case which were not suspected clinically and radiologically.
A successful
homogeneous photoredox catalyst has been fruitfully heterogenized
on magnetic nanoparticles (MNPs) coated with a silica layer, keeping
intact its homogeneous catalytic properties but gaining others due
to the easy magnetic separation and recyclability. The amine-terminated
magnetic silica nanoparticles linked noncovalently to H[3,3′-Co(1,2-C2B9H11)2]− (H[1]), termed MSNPs-NH2@H[1], are highly stable and do not produce any leakage of the photoredox
catalyst H[1] in water. The magnetite MNPs were coated
with SiO2 to provide colloidal stability and silanol groups
to be tethered to amine-containing units. These were the MSNPs-NH2 on which was anchored, in water, the cobaltabis(dicarbollide)
complex H[1] to obtain MSNPs-NH2@H[1]. Both MSNPs-NH2 and MSNPs-NH2@H[1] were evaluated to study the morphology, characterization, and colloidal
stability of the MNPs produced. The heterogeneous MSNP-NH2@H[1] system was studied for the photooxidation of alcohols,
such as 1-phenylethanol, 1-hexanol, 1,6-hexanediol, or cyclohexanol
among others, using catalyst loads of 0.1 and 0.01 mol %. Surfactants
were introduced to prevent the aggregation of MNPs, and cetyl trimethyl
ammonium chloride was chosen as a surfactant. This provided adequate
stability, without hampering quick magnetic separation. The results
proved that the catalysis could be speeded up if aggregation was prevented.
The recyclability of the catalytic system was demonstrated by performing
12 runs of the MSNPs-NH2@H[1] system, each
one without loss of selectivity and yield. The cobaltabis(dicarbollide)
catalyst supported on silica-coated magnetite nanoparticles has proven
to be a robust, efficient, and easily reusable system for the photooxidation
of alcohols in water, resulting in a green and sustainable heterogeneous
catalytic system.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.