Recent progress in polysaccharides from<i>Panax ginseng</i>C. A. Meyer

Guo, Mingkun; Shao, Shuai; Wang, Dandan; Zhao, Daqing; Wang, Mingxing

doi:10.1039/d0fo01896a

Cited by 88 publications

(53 citation statements)

References 132 publications

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“…Modern pharmacological studies have shown that P. ginseng has therapeutic effects on intestinal system diseases, such as ulcerative colitis, Crohn’s bowel disease, and intestinal cancer ( 43 ). The polysaccharide is an important active component of P. ginseng in mediating the inflammatory response and immune function and has obvious inhibitory effects on many pathogenic bacteria ( 44 ). In this study, polysaccharide from P. ginseng was isolated and simi-purified, and its basic physicochemical properties were studied by HPLC, FT-IR, and GPC.…”

Section: Discussionmentioning

confidence: 99%

Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy

et al. 2021

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Polysaccharides from Panax ginseng C. A. Meyer (P. ginseng) are the main active component of P. ginseng and exhibit significant intestinal anti-inflammatory activity. However, the therapeutic mechanism of the ginseng polysaccharide is unclear, and this hinders the application for medicine or functional food. In this study, a polysaccharide was isolated from P. ginseng (GP). The primary structure and morphology of the GP were studied by HPLC, FT-IR spectroscopy, and scanning electron microscopy (SEM). Further, its intestinal anti-inflammatory activity and its mechanism of function were evaluated in experimental systems using DSS-induced rats, fecal microbiota transplantation (FMT), and LPS-stimulated HT-29 cells. Results showed that GP modulated the structure of gut microbiota and restored mTOR-dependent autophagic dysfunction. Consequently, active autophagy suppressed inflammation through the inhibition of NF-κB, oxidative stress, and the release of cytokines. Therefore, our research provides a rationale for future investigations into the relationship between microbiota and autophagy and revealed the therapeutic potential of GP for inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy

et al. 2021

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“…It could be affected by monosaccharide composition, molecular weight, branched chain structure, high-level structure, etc. Existing studies have found that the mechanisms of polysaccharides for hypoglycemic activity mainly include regulation of enzyme activity, liver glucose metabolism, intestinal flora, protection and reparation of pancreatic islet cells, and improvement of insulin sensitivity [ 105 , 106 , 107 , 108 , 109 ].…”

Section: Biological Activitymentioning

confidence: 99%

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Jia

Xue

et al. 2021

Polymers

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Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which possesses antitumor, antioxidant, anti-virus, hypoglycemic, and hypolipidemic activities. In this review, the current advancements on extraction, purification, structural characteristics, and biological activities of IOPS were summarized. This review can provide significant insight into the IOPS bioactivities as their in vitro and in vivo data were summarized, and some possible mechanisms were listed. Furthermore, applications of IOPS were reviewed and discussed; IOPS might be a potential candidate for the treatment of cancers and type 2 diabetes. Besides, new perspectives for the future work of IOPS were also proposed.

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“…Recent studies demonstrated that ginseng extracts, active components (ginsenosides and gintonin), and ginseng formulas can improve the symptoms of AD patients and inhibit the progression of AD by reducing the deposition of Aβ and tau protein hyperphosphorylation. These effects may be mediated by mitochondrial function, neuron conduction, apoptosis, calcium ions, and reactive oxygen species (ROS) ( Rajabian et al, 2019 ; Guo et al, 2021 ). Ginsenosides, which are mainly classified into protopanaxadiol (PPD) and protopanaxatriol (PPT), according to their sapogenin, can result in significant improvement in AD symptoms ( Im and Nah, 2013 ; Kim et al, 2018 ; Piao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Potentials of Panax Ginseng Against Alzheimer’s Disease: A Review of Preclinical and Clinical Evidences

Huang

Chen

et al. 2021

Front. Pharmacol.

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Alzheimer’s disease (AD), a neurodegenerative disorder, is a major health concern in the increasingly aged population worldwide. Currently, no clinically effective drug can halt the progression of AD. Panax ginseng C.A. Mey. is a well-known medicinal plant that contains ginsenosides, gintonin, and other components and has neuroprotective effects against a series of pathological cascades in AD, including beta-amyloid formation, neuroinflammation, oxidative stress, and mitochondrial dysfunction. In this review, we summarize the effects and mechanisms of these major components and formulas containing P. ginseng in neuronal cells and animal models. Moreover, clinical findings regarding the prevention and treatment of AD with P. ginseng or its formulas are discussed. This review can provide new insights into the possible use of ginseng in the prevention and treatment of AD.

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Recent progress in polysaccharides fromPanax ginsengC. A. Meyer

Abstract: Panax ginseng C. A. Meyer (P. ginseng) has a long history of medicinal use and can treat a variety of diseases.

Cited by 88 publications

References 132 publications

Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy

Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Neuroprotective Potentials of Panax Ginseng Against Alzheimer’s Disease: A Review of Preclinical and Clinical Evidences

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