Recent progress in polymer hydrogel bioadhesives

Abstract

Adhesive hydrogels have broad applications in tissue adhesives, hemostatic agents, and biomedical sensors. Various bio‐inspired glues and synthetic adhesives are clinically used as conventional hemostatic agents and auxiliary tools for wound closure. Medical adhesives are needed to effectively and quickly control bleeding, thereby reducing the risk of complications caused by severe blood loss. Medical sensors need to have excellent skin compliance, mechanical properties, sensitivity, and biological safety. This review focuses on recent progress in adhesive hydrogel systems, their structures, adhesion mechanisms, construction strategies, and emerging applications in the biomedical field.

Gradient adhesion modification of polyacrylamide/alginate–calcium tough hydrogels

“…Tissue adhesive hydrogels have great potential applications in wearable strain sensors to monitor human motions. 37–39 Because of the existence of free ions in porous networks, hydrogels have good electrical conductivity. The addition of LiCl can improve the conductivity of hydrogels.…”

Research Progress on Hydrogel–Elastomer Adhesion

“…Compared to the breaking energy of hydrogels (high strength) and elastomers, the adhesion energy based on bonds (non-covalent) and substrates is usually considerably lower [ 30 , 31 , 32 ]. This confines their application in the field of bioelectronics [ 33 , 34 , 35 ]. Hence, the combination of non-covalent interaction and covalent interaction was proposed.…”

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

“…However, the review focuses on the use of HRP-catalyzed hydrogels for hemostasis and drug and cell delivery purposes (Thi et al, 2019). Pei et al also published a review on the polymer hydrogel bioadhesives, with a small section about bioadhesives for tissue engineering applications (Pei et al, 2021). In this article, we aim to provide a comprehensive review on a variety of tissue engineering scaffolds with adhesive properties.…”