Recent progress in mucoadhesive polymers for buccal drug delivery applications

Sharma, Manu; Rathore, Aishwarya; Sharma, Sheelu; Sadhu, Veera; Reddy, Kakarla Raghava; Kulkarni, Raghavendra V.

doi:10.1016/b978-0-12-817923-9.00008-0

Cited by 6 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To improve the efficacy and safety of fentanyl, the drug was incorporated into the mucoadhesive layer and the top protective layer provided unidirectional drug release. The oromucosal films as a dosage form were included in the European Pharmacopoeia (monograph "Oromucosal preparations") in 2012 [177][178][179].…”

Section: Dosage Forms For Oromucosal Applicationmentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

View full text Add to dashboard Cite

Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, which also complicates the absorption of drugs. The development of oromucosal drug delivery systems based on mucoadhesive biopolymers and their derivatives (especially thiolated and catecholated derivatives) is a promising strategy for the pharmaceutical development of safe and effective dosage forms. Solid, semi-solid and liquid pharmaceutical formulations based on biopolymers have several advantageous properties, such as prolonged residence time on the mucosa due to high mucoadhesion, unidirectional and modified drug release capabilities, and enhanced drug permeability. Biopolymers are non-toxic, biocompatible, biodegradable and may possess intrinsic bioactivity. A rational approach to the design of oromucosal delivery systems requires an understanding of both the anatomy/physiology of the oral mucosa and the physicochemical and biopharmaceutical properties of the drug molecule/biopolymer, as presented in this review. This review summarizes the advances in the pharmaceutical development of mucoadhesive oromucosal dosage forms (e.g., patches, buccal tablets, and hydrogel systems), including nanotechnology-based biopolymer nanoparticle delivery systems (e.g., solid lipid particles, liposomes, biopolymer polyelectrolyte particles, hybrid nanoparticles, etc.).

show abstract

Section: Dosage Forms For Oromucosal Applicationmentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…This concept doesn't require any physical interaction between polymer chains and mucus strands that makes it suitable for studying the bioadhesion of rigid polymers that lack flexible chains. 20,23,24 Mucoadhesion properties depend upon the bioadhesive polymer and the surface on which polymer is present. Factors that affect the mucoadhesive properties of a polymer are summarized below.…”

Section: Wetting Theorymentioning

confidence: 99%

A Comprehensive Review on Mucoadhesive Drug Delivery

Chauhan¹,

Singh²

2022

J. Drug Delivery Ther.

View full text Add to dashboard Cite

The two major problems in the development of new drugs are low aqueous solubility and low oral bioavailability. Although, drug delivery via oral route is most preferred for years but it also has some drawbacks. Various techniques for improving the solubility have been developed, however the success of these techniques depends on the physical and chemical properties of the drug under development. In recent years, mucoadhesive drug delivery gained high popularity in comparison to other routes of drug delivery as it can circumvent the drawbacks of conventional delivery system such as first pass metabolism, enzymatic degradation, GI toxicity of some drugs, instability in acidic or alkaline environment and poor bioavailability. Various mucoadhesive dosage forms have been developed recently including tablets, patches, films, ointments, gels etc. The objective of current review is to provide a comprehensive overview of mucoadhesive drug delivery including the mechanism and theories behind mucoadhesion, factors affecting mucoadhesion, different dosage forms, polymers used in mucoadhesive formulations, characterization techniques, marketed products and current scenario & future challenges. Keywords: Mucoadhesion, Buccal mucosa, Mucoadhesive drug delivery, Mucoadhesive polymers, Mucus membrane, Patents

show abstract

“…Therefore, simplification of the manufacturing process to meet safety, efficacy, and regulatory requirements is needed to develop novel buccal dosage forms. [16] The future challenge of pharmaceutical scientists will not only be polypeptide cloning and synthesis, but also to develop effective nonparenteral delivery of intact proteins and peptides to the systemic circulation.…”

Section: Pipeline Development Of Buccal Drug Delivery Systemmentioning

confidence: 99%

Rospective designing and types of buccal drug delivery system: The Review

Rathod¹,

Tekade²,

Bhajipale³

et al. 2020

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. The mucosa of the buccal cavity is the most easily accessible transmucosal site. This fast dissolving drug delivery system (FDDS) is suited for the drugs which undergo high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to mouth plasma peak levels, which in turn minimize adverse/side effects and also make it cost effective This article aims to review the recent Designs of buccal patches and their developments in the buccal adhesive drug delivery systems, & Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules.

show abstract

Recent progress in mucoadhesive polymers for buccal drug delivery applications

Cited by 6 publications

References 48 publications

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

A Comprehensive Review on Mucoadhesive Drug Delivery

Rospective designing and types of buccal drug delivery system: The Review

Contact Info

Product

Resources

About