Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors

MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell

“…17,18 Therefore, the development of safe and efficient miRNA carriers is a prerequisite for the success of combination therapy. Currently, the combination of gene and chemical drugs can be classified into three categories: 1) chemotherapy combined with gene carrying nanoparticles; 19 2) codelivery; 20 and 3) use of multiple nanocarriers.…”

miRNA-182 and the regulation of the glioblastoma phenotype - toward miRNA-based precision therapeutics

“…2,56 A silica-based nanoparticle conjugated with a disialoganglioside GD2 antibody as targeting moiety was used to express miR-34a in neuroblastoma, which reduced tumor growth and vascularization by decreasing the levels of N-myc and increasing tissue inhibitor of metallopeptidase 2 (TIMP2). 57 Polymer-based particles, such as poly(lactic-co-glycolic acid) (PLGA) and polyethyleneimine (PEI) based materials were used to transfer miR-21 and -10b antagonists, and miR-145 into colon carcinomas, 58 where they regulated the avian myelocytomatosis viral oncogene (c-Myc) and ERK5 (see Table 1 for nano-based miRNA therapeutics [59][60][61][62] ).…”

BMI1 as a Potential Target of miR-330-3p in Colorectal Cancer

“…It has been suggested that BMI1 plays a central role in maintaining colorectal cancer cells growth and tumor progression through regulation of self-renewal (29). MiRNAs are considered key factors in cancer genetics and potentially can be used as anti-cancer drugs through their transfer to the cell (30). In addition, miRNAs should be considered as promising targets for cancer diagnosis and treatments monitoring (31).…”