Recent progress in microcalorimetry By E. Calvet and H. Prat, translated from the French by H. A. Skinner. Pp. xii + 177. Pergamon Press, Oxford. 1963. 60s. net

Mortimer, Carole

doi:10.1016/0160-9327(64)90017-1

Cited by 3 publications

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“…1) is responsible for major production losses in New Zealand livestock as the causative agent of the photosensitizing disorder facial eczema. The primary lesion involves liver and bile-duct damage, manifested in sheep as transient hepatocyte degeneration followed by intraand extrahepatic bile-duct injury (Mortimer, 1963). Rats are less susceptible to hepatobiliary injury, but within 1 h of perfusion of 2 mg of sporidesmin to isolated rat liver there was inhibition of bile flow and of bile acid and bilirubin secretion, accompanied by degeneration of the hepatocyte canalicular membrane (Bullock et al, 1974).…”

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Inhibition by sporidesmin of hepatocyte bile acid transport

Cordiner¹,

Jordan²

1983

Biochemical Journal

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Exposure of isolated rat hepatocytes (approx. 2 x 10(7)--5 x 10(7) cells/10ml of incubation mixture) to 0.5 mg of the mycotoxin sporidesmin for 30--60 min at 37 degrees C produced loss of plasma-membrane microvilli with some disruption of organelle distribution in the sub-surface region. There was accompanying inhibition of [14C]cholate and [14C]taurocholate transport, but bile acid conjugation was not altered. Inhibition of cholate uptake was maximal after exposure of hepatocytes to sporidesmin for 1 min, and was not reversed by washing cells free of extracellular sporidesmin. N-Ethylmaleimide (0.1 mM) or dithiothreitol (1 mM) partially protected hepatocytes from sporidesmin inhibition of bile acid uptake. Significant protection was not given by other thiols or by zinc sulphate, cholesterol, ascorbate or alpha-tocopherol. The results are discussed in terms of sporidesmin action on cell membranes and the toxin's effect on bile secretion.

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confidence: 99%

Inhibition by sporidesmin of hepatocyte bile acid transport

Cordiner¹,

Jordan²

1983

Biochemical Journal

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“…Crystalline sporidesmin was prepared (Done, Mortimer, Taylor & Russell, 1961; Ronaldson, Taylor, White & Abraham, 1963) and experimental poisoning of normal sheep was found to be similar to field cases of facial eczema in sheep (Done, Mortimer & Taylor, 1960). Publications on the experimental sporidesmin poisoning of sheep have dealt with clinical and post-mortem observations , with biochemical changes in some serum constituents (Done, Mortimer & Taylor, 1962), with haematological and liver-function disturbances (Mortimer, 1962), and with histological and histochemical observations (Mortimer, 1963).…”

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The composition of the liver lipids of sheep and the effect of early sporidesmin poisoning

Peters¹,

Smith²

1964

Biochemical Journal

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“…Bile-duct and liver lesions in mice were in some respects similar to those described in sporidesmin poisoning of other species such as guineapigs (Evans, McFarlane, Reid, and Perrin 1957), rabbits (Dodd 1960), rats and calves (Mortimer, to be published), and sheep (Mortimer 1963). However, bile-ductular proliferation was not such a marked feature in mouse liver as in other susceptible species, and the extensive degeneration of centrilobular hepatocytes appears to be unique to the mouse.…”

Section: Discussionmentioning

confidence: 67%

“…Sporidesmin, the highly toxic metabolic product of the fungus Pithomyces chartarum (Synge and White 1959), is responsible for pathological changes in the livers of sheep (Mortimer 1963) and cattle (Mortimer, in preparation) which produce in these species a hepatogenous photosensitivity disease known as facial eczema.…”

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confidence: 99%

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The toxic effects of sporidesmin on mice

Mortimer¹

1970

New Zealand Journal of Agricultural Research

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The susceptibility of mice to sporidesmin has been determined in oral feeding experiments in which daily dosing continued until animals were in extremis or dead. Female mice were significantly more susceptible than males. The average total amount given female mice dosed with 0.2 mg daily was 2.7 mg/ 10 g body weight, and at 0.1 mg daily the average total given was 2.2 mg/lO g body weight. These figures, compared with lethal dose levels for other species, indicate that mice are considerably less susceptible to sporidesmin than are rats, chickens, guinea-pigs, and rabbits.The pathological changes produced in the bile ducts and livers of mice were in some respects similar to those produced in the other susceptible animals, and icterus was a usual symptom. In the experimental mice severe pleural effusions and pulmonary oedema were often the cause of death. Previously, sporidesmin-induced thoracic lesions have been seen only in rats and, to a lesser degree, in chickens.

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Recent progress in microcalorimetry By E. Calvet and H. Prat, translated from the French by H. A. Skinner. Pp. xii + 177. Pergamon Press, Oxford. 1963. 60s. net

Cited by 3 publications

References 0 publications

Inhibition by sporidesmin of hepatocyte bile acid transport

Inhibition by sporidesmin of hepatocyte bile acid transport

The composition of the liver lipids of sheep and the effect of early sporidesmin poisoning

The toxic effects of sporidesmin on mice

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