Recent progress in fluorescent probes for detection of carbonyl species: Formaldehyde, carbon monoxide and phosgene

A Ruthenium(II) complex-based probe for colorimetric and luminescent detection and imaging of hydrogen sulfide in living cells and organisms

“…Following the biological investigations of nitric oxide (NO) and carbon monoxide (CO), recent researches have also identified the endogenous H 2 S as a signaling gasotransmitter. Therefore, this gaseous biomolecule has been found to be associated with some of neurodegeneration processes [10][11][12][13]. In principle, endogenous H 2 S in the mammalian systems is mainly produced enzymatically by cystathionine-β-synthase (CBS), cystathionine γ-lyase (CSE), cysteine lyase (CL) and 3-mercaptopyruvate sulfur-transferase (3-MST) [14][15][16][17].…”

Optical chemosensors for the gas phase detection of aldehydes: mechanism, material design, and application

“…26 More recently, gave special attention to the research progress of fluorescent probes based on organic small-molecule dyes with amino group that are capable of detecting three carbonyl species including FA, and enabling solution-phase bioimaging. 30 Although these reviews cover well the current technical status of detection of FA, it remains crucial to provide a more comprehensive review to cover broader sensing mechanisms in correlation with the unique molecular designs, which can potentially expand the detection scope from FA to many other aldehydes.…”

Recent Advances in Fluorescence Light‐Up Endogenous and Exogenous Carbon Monoxide Detection in Biology

“…[1] But the twist in the story lies on the fact that at very low concentration CO acts as a cell-signalling agents thus carry positive influence in biological systems as well. [2][3][4][5] However, abnormal metabolism of CO is the reason for several diseases like hypertension, inflammation, Alzheimer's disease, heart failure, etc. Thus, the act of CO has become inevitably significant to biological systems when its amount is optimum and even can has the potential to act as therapeutic agent.…”

“…[1,[9][10][11][12][13] Research, clinical trials and also treatment for the prevention and cure of these diseases are highly in demand and carried out by introducing low level of CO. [1] But understanding the mechanism is still in its infancy due to detection of low level endogenous CO in subcellular organelles is very tough and promising results are shown mostly by fluorescent detection of the small molecules among various other techniques like piezoelectric sensors, semiconductor sensors, colorimetric probes, quartz crystal microbalance, Raman spectroscopy, transmission electron microscopy, gas chromatography, liquid chromatography and Xray diffraction. [2,[14][15][16][17][18][19][20][21][22][23][24] Although, various methods are available for detection of CO, the fluorescence light-up detection is considered the best method due to its easy and accurate sensing capability. There are mostly three types of mechanism regarding fluorescence turn-on detection of CO molecule both in vivo and in vitro reported often by the scientists in this field (Scheme 1).…”

“…There is a recent review focusing on development of fluorescent probes for the detection of carbonyl species, formaldehyde, carbon monoxide (CO), and phosgene molecules. [2] Up to now, several review articles are available, focusing on the development and detection of several small molecules together with carbon monoxide (CO) in a noninvasive manner. [31][32][33][34] But none of the above are dedicated to cellular non-targetable and targetable CO detection in living cells.…”