A Ruthenium(II) complex-based probe for colorimetric and luminescent detection and imaging of hydrogen sulfide in living cells and organisms

Abstract

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Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

“…The metabolites of H 2 S, such as polysulfides and persulfides, are also important RSS that may have similar or divergent regulatory roles in living systems [ 206 , 207 ]. Recently, by exploiting the response mechanisms of sulfoxide reduction [ 194 ], displacement of Cu 2+ [ 137 ], cleavage of 7-nitro-2,1,3-benzoxadiazoles (NBD) [ 208 ] and DNP [ 209 ], a few Ru(II) complexes have been developed as chemosensors for RSS detection [ 194 ], and these RSS-responsive Ru(II) complexes will be discussed in this section.…”

“…By exploiting the H 2 S-triggered thiolysis of NBD, Ru(II) complex 51 was recently developed by Liu et al for the detection of H 2 S in PBS buffer and in living organisms (Fig. 24 B) [ 208 ]. Similar to complex 50 , the emission quenching of complex 51 was attributed to the PeT from the Ru(II) center to DNB.…”

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

“…The metabolites of H 2 S, such as polysulfides and persulfides, are also important RSS that may have similar or divergent regulatory roles in living systems [206,207]. Recently, by exploiting the response mechanisms of sulfoxide reduction [194], displacement of Cu 2+ [137], cleavage of 7-nitro-2,1,3-benzoxadiazoles (NBD) [208] and DNP [209], a few Ru(II) complexes have been developed as chemosensors for RSS detection [194], and these RSS-responsive Ru(II) complexes will be discussed in this section.…”

“…By exploiting the H 2 S-triggered thiolysis of NBD, Ru(II) complex 51 was recently developed by Liu et al for the detection of H 2 S in PBS buffer and in living organisms (Fig. 24B) [208]. Similar to complex 50, the emission quenching of complex 51 was attributed to the PeT from the Ru(II) center to DNB.…”

Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells

“…Liu et al [ 80 ] reported a ruthenium (Ru) (II) complex-based probe for colorimetric and luminescent detection and imaging of H 2 S in live cells and organisms. This Ru(II) complex was yellow color and nonluminescent in aqueous solution.…”