Recent progress in circular RNAs in human cancers

Huang, Guofu; Li, Shuaihu; Yang, Nuo; Zou, Yongdong; Zheng, Duo; Xiao, Tian

doi:10.1016/j.canlet.2017.07.002

Cited by 94 publications

(75 citation statements)

References 85 publications

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“…Deficiency of Nrf2 in mice could replicate transcriptomic changes in patients with AD [15]. Exacerbation of degeneration of nigral dopaminergic neurons and increased expression of α-synuclein were observed in Nrf2-knockout mice, which cooperated to aggravate neuronal death and inflammation in early-stage PD [16].…”

Section: Introductionmentioning

confidence: 95%

“…Moreover, circRNAs are preferentially expressed in neural tissues along neural genes [18] that are associated with various diseases in the central nervous system (CNS), such as AD, PD and ischaemia [19][20][21]. CircRNA CDR1as, an antisense transcript of CDR1, was reported to be involved with the pathogenesis of PD [20].…”

Section: Introductionmentioning

confidence: 99%

“…As an evolutionarily conserved type of non-coding RNAs, circular RNAs (circRNAs) are formed by exon skipping or back-splicing events that are expressed abundantly in mammalian cells [15]. Moreover, circRNAs are preferentially expressed in neural tissues along neural genes [18] that are associated with various diseases in the central nervous system (CNS), such as AD, PD and ischaemia [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

Yang¹,

Zhang²,

Lin³

et al. 2018

Cell Physiol Biochem

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Background/Aims: The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway plays a protective role in both acute neuronal damage and chronic neurodegeneration-related oxidative stress. Circular RNAs (circRNAs) are involved with various diseases in the central nervous system (CNS). This study aimed to identify the key circRNAs involved in Nrf2-neuroprotection against oxidative stress. Methods: The differentially expressed circRNAs (DEcircRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice were identified by microarray analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) was then used to validate the expression of selected DEcircRNAs in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice. Based on our previous microarray analysis of the differentially expressed mRNAs (DEmRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice, the DEcircRNA-miRNA-DEmRNA interaction network was constructed. Functional annotation of DEmRNAs that shared the same binding miRNAs with DEcircRNAs was performed using gene ontology (GO) and pathway analyses. Results: A total of 65 and 150 significant DEcircRNAs were obtained in the substantia nigra and corpus striatum of Nrf2 (-/-) mice, respectively, and seventeen shared DEcircRNAs were found in both these two tissues. The qRT-PCR results were generally consistent with the microarray results. The DEcircRNA-miRNA-DEmRNA interaction network and pathway analysis indicated that mmu_circRNA_34132, mmu_circRNA_017077 and mmu-circRNA-015216 might be involved with Nrf2-mediated neuroprotection against oxidative stress. Mmu_circRNA_015216 and mmu_circRNA_017077 might play roles in the Nrf2-related transcriptional misregulation and Nrf2-mediated processes of rheumatoid arthritis, respectively. In addition to these two processes, mmu_circRNA_34132 may be a potential regulator of Nrf2-mediated protection for diabetes mellitus and Nrf2-mediated defence against ROS in hearts. Conclusion: In conclusion, our study identified the key DEcircRNAs in the substantia nigra and corpus striatum of Nrf2 (-/-) mice, which might provide new clues for further exploring the mechanism of Nrf2-mediated neuroprotection against oxidative stress and other Nrf2-mediated processes.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

Yang¹,

Zhang²,

Lin³

et al. 2018

Cell Physiol Biochem

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“…MiRNAs frequently are dysregulated in cancer and have shown great potential as tissue‐based markers for cancer classification and prognostication . Because some miRNAs also are secreted into the blood as cell‐free miRNAs, which can be detected in serum in highly stable form, circulating miRNAs are emerging as promising, minimally invasive biomarkers for diagnosing and monitoring human cancers …”

Section: Introductionmentioning

confidence: 99%

Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer

Zhang

Raju

Chang

et al. 2017

Cancer

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“…They could also serve as a transcriptional regulator or protein-binding RNA [16,17], or even be translated directly into proteins under certain circumstances [18]. Many potential circRNA molecular markers and their pathways as miRNA sponges have been discovered in many tumors, including esophageal squamous carcinoma, gastric cancer, pancreatic ductal adenocarcinoma, liver cancer, colorectal cancer, early-stage lung adenocarcinoma, glioma, and ovarian cancer [19][20][21]. However, the role of circRNA in the progression of cervical cancer has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

Liu

Wang

Long

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) play a significant role in the development and progression of various human cancers. However, the expression and function of circRNAs in cervical cancer (CC) have rarely been explored. The aim of this study was to investigate the biological function of circRNA8924 in CC and elucidate the possible molecular mechanism involved. Methods: Quantitative polymerase chain reaction was used to determine mRNA expression of circRNA8924, miR-518d-5p/519-5p and CBX8 in CC tissues and cells. CBX8 protein expression was measured by Western blotting. The CCK-8 assay was used to evaluate cell proliferation, and the transwell assay to determine cell migration and invasion. The luciferase reporter assay was used to determine the direct regulation of miR-518d-5p/519-5p and circRNA8924 or CBX8 Results: The study demonstrated that the expression level of circRNA8924 in CC was significantly higher than that in the adjacent normal tissues (P < 0.001), and that it was also associated with tumor size, FIGO staging and myometrial invasion. The knockdown of circRNA8924 significantly inhibited the proliferation, migration and invasion of CC cells SiHa and HeLa. The expression level of miR-518d-5p/519-5p was negatively correlated with circRNA8924, and circRNA8924 regulated CBX8 by competitively binding to miR-518d-5p/519-5p. Conclusions: CircRNA8924 is highly expressed in CC tissue and can be considered a competitive endogenous RNA of the miR-518d-5p/519-5p family to promote the malignant biological behavior of CC cells. It is suggested that it may serve as a new biomarker for CC diagnosis and disease progression and provide potential targets for targeted therapy.

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Recent progress in circular RNAs in human cancers

Cited by 94 publications

References 85 publications

The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

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