Recent Progress in Artificial Organ Research at Tohoku University

Yambe, Tomoyuki; Yoshizawa, Makoto; Abe, Ken; Kawano, Shoichi; Matsuki, H.; Maruyama, Shigenao; Amae, Shintato; Wada, Naoshi; Kamiyama, Takamichi; Takagi, Toshiyuki; Luo, Run; Hayashi, Junko; Kovalev, Yuri A.; Sha, Dan X.D.; Nanka, S.; Saijo, Yoshifumi; Mibiki, Yoshiyuki; Shibata, Manabu; Nitta, Shin Ichi

doi:10.1046/j.1525-1594.2003.07181.x

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…With the squeezing action of direct cardiac compression, there is a possibility coronary blood flow may be limited, which may even lead to LV ischemia. So in the surgical technique used to insert EHAM, it is important not to tighten the belt diaphragm excessively in order to avoid limited the coronary blood flow (4).…”

Section: Discussionmentioning

confidence: 99%

An Artificial Myocardium Assist System: Electrohydraulic Ventricular Actuation Improves Myocardial Tissue Perfusion in Goats

et al. 2004

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Section: Discussionmentioning

confidence: 99%

An Artificial Myocardium Assist System: Electrohydraulic Ventricular Actuation Improves Myocardial Tissue Perfusion in Goats

et al. 2004

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“…However, a patient using a VAD has a weak heart; therefore, pulse generation becomes dependent solely on the VAD. We have developed the artificial myocardium (21), a system that helps contraction. The artificial myocardium and RP were used in combination in this study.…”

Section: Pulsation Devicesmentioning

confidence: 99%

Development of the Pulsation Device for Rotary Blood Pumps

et al. 2005

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A rotary blood pump (RP) is desirable as a small ventricular assist device (VAD). However, an RP is nonpulsatile. We tried to develop a device that attaches a pulse to the RP. We also tried to develop a pulse-generating equipment that was not air-pressure driven. The ball screw motor was considered a candidate. The application of a small-sized shape memory alloy was also attempted. An electrohydraulic system was adopted, and actuator power was connected to the diaphragm. The diaphragm was placed on the outer side of the ventricle. Most RPs that have been developed all over the world drain blood from the ventricle. The wave of a pulse should be generated if a pulse is added by the drawn part. The output assistance from the outer side of the ventricle was attempted in animal experiments, and the device operated effectively. This device can be used during implantable operation of RP. This may serve as an effective device in patients experiencing problems in peripheral circulation and in the function of internal organs.

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“…For the system to be totally implantable, one of the important considerations is the energy support system (15–19). In Tohoku University, a highly efficient transcutaneous energy transmission system (TETS) has been developed by the use of amorphous fibers for the magnetic shielding (20). For the UPVAD a smaller TETS was developed and this is shown in Fig.…”

Section: Implantable Undulation Pump Ventricular Assist Devicementioning

confidence: 99%

Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

et al. 2004

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It is well known that a rotary blood pump (RP) is effective as a small ventricular assist device (VAD). It might be still more effective if pulsation was available. The undulation pump (UP), which is a type of small RP, can also produce pulsation. In Japan, a development project for an implantable type UP ventricular assist device (UPVAD) is now advanced. Six universities and some companies together have been in charge of the development project for 5 years. In this study, the influence which the UP under development has on circulation in internal organs was investigated. Goats with the same weight as an average Asian person were used for the experiment. The left chest cavity was opened after resection of the fourth rib and the heart was approached. A cannula was inserted in the left ventricle from the apex. An outflow cannula was inserted into the left descending aorta. Heart muscle was excised using a newly developed puncher. The UPVAD was implanted using a left-heart bypass system. The myocardial blood flow, carotid arterial blood flow, and the kidney blood flow were recorded together with an electrocardiogram, blood pressure, and the flow rate. In these animal experiments, the blood circulation dynamic state was stabilized and sufficient support of the left heart was observed. Myocardial blood flow, carotid arterial flow, and a kidney blood flow increase resulting from UPVAD support was observed. Often the problem of multiple organ failure is important at the time of clinical application of a ventricular assist device. Assisting circulation to internal organs is important for prevention of multiple organ failure. It was concluded that the UPVAD might be useful for prevention of multiple organ failure.

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Recent Progress in Artificial Organ Research at Tohoku University

Cited by 13 publications

References 10 publications

An Artificial Myocardium Assist System: Electrohydraulic Ventricular Actuation Improves Myocardial Tissue Perfusion in Goats

An Artificial Myocardium Assist System: Electrohydraulic Ventricular Actuation Improves Myocardial Tissue Perfusion in Goats

Development of the Pulsation Device for Rotary Blood Pumps

Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

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