Recent preclinical study offers a promising clue: Role of regulatory T cells as biomarkers in migraine

Arumugam, Murugesan; S, Sugin Lal Jabaris

doi:10.1016/j.imlet.2021.09.004

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…These may reflect specific alterations associated with the pathophysiology and severity of migraine. Among the most relevant findings that can be highlighted are a reduction in CD4+ CD25+ regulatory T cells [418][419][420]; higher CD3, CD4, CD8, and CD19 in patients with chronic migraine compared with episodic migraine [421]; or increased proportion of Treg CD45R0+ CD62L−, and CD45R0-CD62L− cells [422]. Also, a study comparing episodic migraine patients with healthy controls revealed higher values of several lymphocyte-related blood parameters in migraineurs.…”

Section: Immune Systemmentioning

confidence: 99%

Understanding the Biological Relationship between Migraine and Depression

Viudez-Martínez,

Torregrosa,

Navarrete

et al. 2024

Biomolecules

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Migraine is a highly prevalent neurological disorder. Among the risk factors identified, psychiatric comorbidities, such as depression, seem to play an important role in its onset and clinical course. Patients with migraine are 2.5 times more likely to develop a depressive disorder; this risk becomes even higher in patients suffering from chronic migraine or migraine with aura. This relationship is bidirectional, since depression also predicts an earlier/worse onset of migraine, increasing the risk of migraine chronicity and, consequently, requiring a higher healthcare expenditure compared to migraine alone. All these data suggest that migraine and depression may share overlapping biological mechanisms. Herein, this review explores this topic in further detail: firstly, by introducing the common epidemiological and risk factors for this comorbidity; secondly, by focusing on providing the cumulative evidence of common biological aspects, with a particular emphasis on the serotoninergic system, neuropeptides such as calcitonin-gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), substance P, neuropeptide Y and orexins, sexual hormones, and the immune system; lastly, by remarking on the future challenges required to elucidate the etiopathological mechanisms of migraine and depression and providing updated information regarding new key targets for the pharmacological treatment of these clinical entities.

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Section: Immune Systemmentioning

confidence: 99%

Understanding the Biological Relationship between Migraine and Depression

Viudez-Martínez,

Torregrosa,

Navarrete

et al. 2024

Biomolecules

View full text Add to dashboard Cite

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“…Conventional Th cells control adaptive immunity by activating other effector cells, such as CD8 + cytotoxic T cells, B cells, and macrophages ( Feau et al, 2012 ). Treg cells are defined as T cells in charge of suppression of potentially deleterious activities of Th cells, regulation of the effector class of the immune response, and suppression of T-cell activation ( Corthay, 2009 ; Arumugam and Sugin Lal Jabaris, 2021 ). The study of CD4 + T cells has tremendous potential to contribute to cancer immunotherapy ( Yuan et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

Yao

et al. 2021

Front. Cell Dev. Biol.

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Gastric cancer (GC) is a malignant disease of the digestive tract and a life-threatening disease worldwide. Ferroptosis, an iron-dependent cell death caused by lipid peroxidation, is reported to be highly correlated with gastric tumorigenesis and immune cell activity. However, the underlying relationship between ferroptosis and the tumor microenvironment in GC and potential intervention strategies have not been unveiled. In this study, we profiled the transcriptome and prognosis data of ferroptosis-related genes (FRGs) in GC samples of the TCGA-STAD dataset. The infiltrating immune cells in GC were estimated using the CIBERSORT and XCELL algorithms. We found that the high expression of the hub FRGs (MYB, PSAT1, TP53, and LONP1) was positively correlated with poor overall survival in GC patients. The results were validated in an external GC cohort (GSE62254). Further immune cell infiltration analysis revealed that CD4+ T cells were the major infiltrated cells in the tumor microenvironment of GC. Moreover, the hub FRGs were significantly positively correlated with activated CD4+ T cell infiltration, especially Th cells. The gene features in the high-FRG score group were enriched in cell division, DNA repair, protein folding, T cell receptor, Wnt and NIK/NF-kappaB signaling pathways, indicating that the hub FRGs may mediate CD4+ T cell activation by these pathways. In addition, an upstream transcriptional regulation network of the hub FRGs by lncRNAs was also developed. Three lncRNAs (A2M-AS1, C2orf27A, and ZNF667-AS1) were identified to be related to the expression of the hub FRGs. Collectively, these results showed that lncRNA A2M-AS1, C2orf27A, and ZNF667-AS1 may target the hub FRGs and impair CD4+ T cell activation, which finally leads to poor prognosis of GC. Effective interventions for the above lncRNAs and the hub FRGs can help promote CD4+ T cell activation in GC patients and improve the efficacy of immunotherapy. These findings provide a novel idea of GC immunotherapy and hold promise for future clinical application.

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Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine

Zhou,

Pang,

et al. 2023

Mol Neurobiol

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Recent preclinical study offers a promising clue: Role of regulatory T cells as biomarkers in migraine

Cited by 4 publications

References 12 publications

Understanding the Biological Relationship between Migraine and Depression

Understanding the Biological Relationship between Migraine and Depression

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine

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