Recent pharmacological advances on genistein in clinical trials

Mathew, Shimy; Vazhappilly, Cijo George

doi:10.17179/excli2020-2675

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Among the evidence, the anthocyanin-rich extract from black rice has been reported to alleviate chronic alcohol consumption-induced liver injury; naringin has beneficial effects in reducing alcohol expose-caused oxidative stress in the zebrafish liver; , quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-κB and STAT3 pathways; catechin alleviates alcoholic liver disease by suppressing the induction of the NF-κB pathway; resveratrol administration decreased lipid synthesis, increased fatty acid oxidation, and prevented alcoholic hepatic steatosis by upregulating the SIRT1–AMPK signaling pathway. , The isoflavone genistein is the main polyphenol component of the soybean. It has been claimed to possess pharmacological properties against various chronic diseases, such as cardiovascular disease, obesity, type 2 diabetes mellitus, and fatty liver disease. − Among the known mechanisms behind the beneficial roles of genistein, antioxidation is the most recognized one based on the evidence from epidemiological, clinical, and experimental animal studies. − Oxidative stress is a state of imbalance between oxidation and antioxidation. It plays an essential role in almost all stages of ALD pathogenesis .…”

Section: Discussionmentioning

confidence: 99%

Genistein Protects against Acetaldehyde-Induced Oxidative Stress and Hepatocyte Injury in Chronic Alcohol-Fed Mice

Ding

Hao

et al. 2023

J. Agric. Food Chem.

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Alcohol-related liver disease (ALD) is one of the most prevalent forms of liver disease in the world. Acetaldehyde, an intermediate product of alcohol catabolism, is a cause of liver injury caused by alcohol. This study was designed to evaluate the protective role and mechanism(s) of genistein against acetaldehyde-induced liver injury in the pathological process of ALD. We found that genistein administration significantly ameliorated alcohol-induced hepatic steatosis, injury, and inflammation in mice. Genistein supplementation markedly reversed hepatic oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and hepatocellular apoptosis in both alcohol-fed mice liver and acetaldehyde-treated hepatocytes. The mechanistic experiments revealed that the restoration of genistein administration rescued heme oxygenase-1 (HO-1) reduction at both transcriptional and protein levels in either alcohol-fed mice liver or acetaldehyde-treated hepatocytes, and the beneficial aspects derived from genistein were abolished in antioxidase heme oxygenase-1 (HO-1)-deficient hepatocytes. Moreover, we confirmed that genistein administrationrestored hepatic nuclear factor erythroid 2-related factor 2 (NRF2), a key transcriptional regulator of HO-1, was involved in the protective role of genistein in ALD. This study demonstrated that genistein ameliorated acetaldehyde-induced oxidative stress and liver injury by restoring the hepatic NRF2−HO-1 signaling pathway in response to chronic alcohol consumption. Therefore, genistein may serve as a potential therapeutic choice for the treatment of ALD.

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Section: Discussionmentioning

confidence: 99%

Genistein Protects against Acetaldehyde-Induced Oxidative Stress and Hepatocyte Injury in Chronic Alcohol-Fed Mice

Ding

Hao

et al. 2023

J. Agric. Food Chem.

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“…Genistein is an isoflavone (5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one), the main source of which is legumes, especially soybeans. It is also present in broad beans, chickpeas, vegetables, fruits, and nuts [ 76 ]. It is worth noting that genistein, which is an aglycone of genistin, is present in soy products because genistin is dominant in unprocessed soybeans [ 77 ].…”

Section: Survey Of Antioxidants That Affected Bpa Toxicitymentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

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BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the molecular level, bisphenol A (BPA) causes an increased production of ROS and hence a change in the redox balance, mitochondrial dysfunction, and modulation of cell signaling pathways. Importantly, these changes accumulate in animals and humans, and BPA toxicity may be aggravated by poor diet, metabolic disorders, and coexisting diseases. Accordingly, approaches using antioxidants to counteract the negative effects of BPA are being considered. The preliminary results that are described in this paper are promising, however, it should be emphasized that further studies are required to determine the optimal dosage and treatment regimen to counteract BPA toxicity. It also seems necessary to have a more holistic approach showing, on the one hand, the influence of BPA on the overall human metabolism and, on the other hand, the influence of antioxidants in doses that are acceptable with the diet on BPA toxicity. This is due in part to the fact that in many cases, the positive effect of antioxidants in in vitro studies is not confirmed by clinical studies. For this reason, further research into the molecular mechanisms of BPA activity is also recommended.

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“…Genistein is a phytoestrogen obtained from soy-derived foods [ 81 ]. Genistein protects against sodium fluoride (NaF)-induced molecular toxicity.…”

Section: Nephroprotective Effects Of Flavonoidsmentioning

confidence: 99%

Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

Alsawaf

Alnuaimi

Afzal

et al. 2022

Biology

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The kidney is susceptible to reactive oxygen species-mediated cellular injury resulting in glomerulosclerosis, tubulointerstitial fibrosis, tubular cell apoptosis, and senescence, leading to renal failure, and is a significant cause of death worldwide. Oxidative stress-mediated inflammation is a key player in the pathophysiology of various renal injuries and diseases. Recently, flavonoids’ role in alleviating kidney diseases has been reported with an inverse correlation between dietary flavonoids and kidney injuries. Flavonoids are plant polyphenols possessing several health benefits and are distributed in plants from roots to leaves, flowers, and fruits. Dietary flavonoids have potent antioxidant and free-radical scavenging properties and play essential roles in disease prevention. Flavonoids exert a nephroprotective effect by improving antioxidant status, ameliorating excessive reactive oxygen species (ROS) levels, and reducing oxidative stress, by acting as Nrf2 antioxidant response mediators. Moreover, flavonoids play essential roles in reducing chemical toxicity. Several studies have demonstrated the effects of flavonoids in reducing oxidative stress, preventing DNA damage, reducing inflammatory cytokines, and inhibiting apoptosis-mediated cell death, thereby preventing or improving kidney injuries/diseases. This review covers the recent nephroprotective effects of flavonoids against oxidative stress-mediated inflammation in the kidney and their clinical advancements in renal therapy.

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Recent pharmacological advances on genistein in clinical trials

Cited by 4 publications

References 25 publications

Genistein Protects against Acetaldehyde-Induced Oxidative Stress and Hepatocyte Injury in Chronic Alcohol-Fed Mice

Genistein Protects against Acetaldehyde-Induced Oxidative Stress and Hepatocyte Injury in Chronic Alcohol-Fed Mice

Can Antioxidants Reduce the Toxicity of Bisphenol?

Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

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