Recent Patents Review in Microencapsulation of Pharmaceuticals Using the Emulsion Solvent Removal Methods

Abstract

Several methods and techniques are potentially useful for the preparation of polymeric microparticles in the broad field of microencapsulation. The preparation method determines the type and the size of microparticle and influence the ability of the interaction among the components used in microparticle formulations. This review is devoted to describe and allocate the recently awarded and pending patents regarding the technical and formulation innovations in microparticles involved in drug delivery that are based mainly on the emulsion solvent removal methods. The term microparticle designates systems larger than one micrometer in diameter and is used usually to describe both microcapsules and microspheres. Microparticle-containing drugs are employed for various purposes including--but not restricted to--controlled drug delivery, masking the taste and odor of drugs, protection of the drugs from degradation, and protection of the body from the toxic effects of the drugs. Polymeric carriers being essentially multidisciplinary are commonly utilized in microparticle fabrication and they can be of an erodible or a non-erodible type.

Fabrication of Fucoxanthin-Loaded Microsphere(F-LM) By Two Steps Double-Emulsion Solvent Evaporation Method and Characterization of Fucoxanthin before and after Microencapsulation

“…This frequently leads to a decrease in microsphere size 40 . Keegan 31 pointed out that the stabilization of the microsphere emulsion with PVA is due to surface hydroxyl groups.…”

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

“…10 The ability of hyaluronic acid and chondroitin sulfate to thicken enables formation of a gelled structure with which the drug interacts and in which it remains trapped, thus delaying its release. 25 After 25 days of incubation, the microparticles remaining in the dialysis membrane were observed by scanning electron microscopy ( Figure 6).…”

“…9 Microparticles are a novel therapy in arthritis, because they can act as small reservoir systems for drugs such as methylprednisolone. 10 The drug release profile depends on various parameters, including size, morphology, porosity, degradability, polymer permeability, and surface features of the active compound. 11 Another feature of microparticles is their ability to target drugs, in particular those with high toxicity and those having a low therapeutic index, to specific tissues 12,13 Drug targeting can reduce the number of doses required while increasing the drug concentration at the desired site, thus contributing to a decrease or inhibition of toxic effects.…”

Cyclodextrin-Based Microcapsule Materials - Their Preparation and Physiochemical Properties

“…Microencapsulation products (microparticles) are small entities in the diameter range of 1-1000 μm containing an active agent or core material surrounded by a shell or embedded within a matrix structure [5]. Commercial microparticles typically possess diameters ~ 3-800 μm with ~10-90% w/w core material [5].…”

“…Microencapsulation products (microparticles) are small entities in the diameter range of 1-1000 μm containing an active agent or core material surrounded by a shell or embedded within a matrix structure [5]. Commercial microparticles typically possess diameters ~ 3-800 μm with ~10-90% w/w core material [5]. Various core materials can be used for encapsulation of adhesives, agrochemicals, live cells, active enzymes, flavors, fragrances, pharmaceuticals, inks, and so forth [5].…”