Fabrication of Fucoxanthin-Loaded Microsphere(F-LM) By Two Steps Double-Emulsion Solvent Evaporation Method and Characterization of Fucoxanthin before and after Microencapsulation

Noviendri, Dedi; Jaswir, Irwandi; Taher, Muhammad; Mohamed, Farahidah; Salleh, Hamzah Mohd.; Noorbatcha, Ibrahim Ali; Octavianti, Fitri; Lestari, Widya; Hendri, Ridar; Ahmad, Hasna; Miyashita, Kazuo; Abdullah, Alias

doi:10.5650/jos.ess16018

Cited by 30 publications

(18 citation statements)

References 39 publications

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“…They demonstrated that PVA could produce the smallest MPs dimensions, while SDS the biggest one. In particular from this comparative study, PVA showed to give the appropriate size value for the preparation for MPs for inhalatory route (Noviendri et al 2016). Particle size is of fundamental importance for the chosen route of administration, for example, for intra-myocardial applications, the appropriate size value is around 5-8 um while for inhalatory or parental is around 1-5 μm.…”

Section: Physicochemical Characterization: Morphology Size Aerodynamentioning

confidence: 83%

“…Other methods/analyses have been recently reported in literature to evaluate encapsulation efficacy and structural and chemical integrity of drugs. For example, thermogravimetry analysis (TGA), glass transition (T g ) temperature measured using differential scanning calorimetry (DSC) (Dwivedi et al 2018), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) (Noviendri et al 2016) and X-ray diffraction (XRD) (Xia et al 2017) of PLGA MPs were employed for controlling drug stability. The interaction between drug and polymer can be studied by FITR spectroscopy: Keles et al (2014) used FTIR spectroscopic imaging to evaluate the redistribution and release of hGH from a range of PLGA/PLA MPs.…”

Section: Drug Encapsulation and Its Loading Efficiency Evaluationmentioning

confidence: 99%

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Recent advances in the formulation of PLGA microparticles for controlled drug delivery

et al. 2020

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Polymeric microparticles (MPs) are recognized as very popular carriers to increase the bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different kinds of polymers, poly-(lactic-co-glycolic acid) (PLGA) is one of the most accepted materials for this purpose, because of its biodegradability (due to the presence of ester linkages that are degraded by hydrolysis in aqueous environments) and safety (PLGA is a Food and Drug Administration (FDA)-approved compound). Moreover, its biodegradability depends on the number of glycolide units present in the structure, indeed, lower glycol content results in an increased degradation time and conversely a higher monomer unit number results in a decreased time. Due to this feature, it is possible to design and fabricate MPs with a programmable and time-controlled drug release. Many approaches and procedures can be used to prepare MPs. The chosen fabrication methodology influences size, stability, entrapment efficiency, and MPs release kinetics. For example, lipophilic drugs as chemotherapeutic agents (doxorubicin), anti-inflammatory non-steroidal (indomethacin), and nutraceuticals (curcumin) were successfully encapsulated in MPs prepared by single emulsion technique, while water-soluble compounds, such as aptamer, peptides and proteins, involved the use of double emulsion systems to provide a hydrophilic compartment and prevent molecular degradation. The purpose of this review is to provide an overview about the preparation and characterization of drug-loaded PLGA MPs obtained by single, double emulsion and microfluidic techniques, and their current applications in the pharmaceutical industry. Graphic abstract

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Section: Physicochemical Characterization: Morphology Size Aerodynamentioning

confidence: 83%

Section: Drug Encapsulation and Its Loading Efficiency Evaluationmentioning

confidence: 99%

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

et al. 2020

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“…As a result, the Tg of leuprorelin-containing PLGA microspheres increased gradually from 42 to 47 • C, with its payload rising from 0 to 8%. Noviendri et al performed a TG experiment to suggest that there were no strong chemical interactions between fucoxanthin and the polymeric matrix of PLGA microspheres [10]. Most relevant studies, however, did not take into account the inter-relationships between residual solvent, drug, and PLGA.…”

Section: Effect Of Progestrone Upon Thermal Behavior Of Ethyl Formatementioning

confidence: 99%

“…Further, when a following thermal event overlaps any stages of a preceding thermal event, it is not easy to assess each event qualitatively or quantitatively. Therefore, in many studies of characterizing PLGA-based micro-/nano-particles through TG experiments, information on residual solvents was not thoroughly discussed [8][9][10][11]. To identify and quantify gas byproducts, TG should be combined with the so-called evolved gas analysis (EGA).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry

Shim

Sah

2020

Pharmaceutics

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Thermogravimetry does not give specific information on residual organic solvents in polymeric matrices unless it is hyphenated with the so-called evolved gas analysis. The purpose of this study was to apply, for the first time, derivative thermogravimetry (DTG) to characterize a residual solvent and a drug in poly-d,l-lactide-co-glycolide (PLGA) microspheres. Ethyl formate, an ICH class 3 solvent, was used to encapsulate progesterone into microspheres. DTG provided a distinct peak, displaying the onset and end temperatures at which ethyl formate started to evolve from to where it completely escaped out of the microspheres. DTG also gave the area and height of the solvent peak, as well as the temperature of the highest mass change rate of the microspheres. These derivative parameters allowed for the measurement of the amount of residual ethyl formate in the microspheres. Interestingly, progesterone affected not only the residual solvent amount but also these derivative parameters. Another intriguing finding was that there was a linear relationship between progesterone content and the peak height of ethyl formate. The residual solvent data calculated by DTG were quite comparable to those measured by gas chromatography. In summary, DTG could be an efficient and practical quality control tool to evaluate residual solvents and drugs in various polymeric matrices.

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“…The mixture is then dispersed in the liquid manufacturing vehicle with continuous agitation to obtain tiny capsules with desired size (Figure 4). In the pharmaceutical industries, the obtained polymer microspheres with an active drug trapped inside can degrade and release the encapsulated drug slowly with a specific release profile [57,58,59]. Misal [3] prepared fucoxanthin-loaded microspheres (F-LM) via a two step w/o/w double emulsion solvent evaporation method with poly ( l -lactic-co-glycolic acid) (PLGA) as the carrier.…”

Section: Research Advances In Microencapsulationmentioning

confidence: 99%

Research Advances of Microencapsulation and Its Prospects in the Petroleum Industry

Guo

et al. 2017

Materials

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Additives in the petroleum industry have helped form an efficient system in the past few decades. Nowadays, the development of oil and gas has been facing more adverse conditions, and smart response microcapsules with the abilities of self-healing, and delayed and targeted release are introduced to eliminate obstacles for further exploration in the petroleum industry. However, limited information is available, only that of field measurement data, and not mechanism theory and structural innovation data. Thus we propose that the basic type, preparation, as well as mechanism of microcapsules partly depend on other mature fields. In this review, we explore the latest advancements in evaluating microcapsules, such as X-ray computed tomography (XCT), simulation, and modeling. Finally, some novel microencapsulated additives with unparalleled advantages, such as flexibility, efficiency, and energy-conservation are described.

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Fabrication of Fucoxanthin-Loaded Microsphere(F-LM) By Two Steps Double-Emulsion Solvent Evaporation Method and Characterization of Fucoxanthin before and after Microencapsulation

Cited by 30 publications

References 39 publications

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry

Research Advances of Microencapsulation and Its Prospects in the Petroleum Industry

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