Recent Patents, Formulation Techniques, Classification and Characterization of Liposomes

Sheoran, Reena; Khokra, Sukhbir Lal; Chawla, Viney; Dureja, Harish

doi:10.2174/1872210513666181127110413

Cited by 43 publications

(23 citation statements)

References 50 publications

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“…Liposomes are lipid vesicles that can incorporate drugs or genetic material inside (hydrophilic compartment) or in the hydrophobic side (lipidic membrane) depending on the hydrophilic or hydrophobic characteristics of the molecules, respectively. Different methods can be used to synthesize liposomal formulations and for their characterization and numerous patented formulations have been described (for a more comprehensive review on this see [204]). The delivery of cargo in non-targeted liposomes is mediated by the EPR effect [205].…”

Section: Lipid Basedmentioning

confidence: 99%

Gene Therapy in Cancer Treatment: Why Go Nano?

et al. 2020

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The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications.

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Section: Lipid Basedmentioning

confidence: 99%

Gene Therapy in Cancer Treatment: Why Go Nano?

et al. 2020

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“…Studies on liposomes in the biomedical field have focused primarily on their application as drug nanocarriers for disease treatment (Li et al, 2017). However, liposomes also have application value in disease diagnosis because of their cell-specific targeting ability (Lamichhane et al, 2018;Sheoran et al, 2019). Reported methods for the preparation of liposomes include ultrasonic, ethanol injection, lipid membrane hydration, and microemulsion methods (Sheoran et al, 2019).…”

Section: Liposome-based Nanomaterialsmentioning

confidence: 99%

“…However, liposomes also have application value in disease diagnosis because of their cell-specific targeting ability (Lamichhane et al, 2018;Sheoran et al, 2019). Reported methods for the preparation of liposomes include ultrasonic, ethanol injection, lipid membrane hydration, and microemulsion methods (Sheoran et al, 2019). Liposomes are able to separate and dissolve both hydrophilic and hydrophobic materials.…”

Section: Liposome-based Nanomaterialsmentioning

confidence: 99%

Advanced Biomimetic Nanomaterials for Non-invasive Disease Diagnosis

et al. 2021

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In modern society, the incidence of cancer, inflammatory diseases, nervous system diseases, metabolic diseases, and cardiovascular diseases is on the rise. These diseases not only cause physical and mental suffering for patients, but also place an enormous burden on society. Early, non-invasive diagnosis of these diseases can reduce the physical and mental pain of patients and social stress. There is an urgent need for advanced materials and methods for non-invasive disease marker detection, large-scale disease screening, and early diagnosis. Biomimetic medical materials are synthetic materials designed to be biocompatible or biodegradable, then developed for use in the medical industry. In recent years, with the development of nanotechnology, a variety of biomimetic medical materials with advanced properties have been introduced. Biomimetic nanomaterials have made great progress in biosensing, bioimaging, and other fields. The latest advance of biomimetic nanomaterials in disease diagnosis has attracted tremendous interest. However, the application of biomimetic nanomaterials in disease diagnosis has not been reviewed. This review particularly focuses on the potential of biomimetic nanomaterials in non-invasive disease marker detection and disease diagnosis. The first part focuses on the properties and characteristics of different kinds of advanced biomimetic nanomaterials. In the second part, the recent cutting-edge methods using biosensors and bioimaging based on biomimetic nanomaterials for non-invasive disease diagnosis are reviewed. In addition, the existing problems and future development of biomimetic nanomaterials is briefly described in the third part. The application of biomimetic nanomaterials would provide a novel and promising diagnostic method for non-invasive disease marker detection, large-scale clinical screening, and diagnosis, promoting the exploitation of devices with better detection performance and the development of global clinical public health.

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“…Liposomes are small spherical vesicles consisting of phospholipid bilayers [98]. They have been extensively used as potent drug delivery systems for various biologically active substances due to their low cytotoxicity, high solubility, excessive biocompatibility, and limited biodegradability [99].…”

Section: Curcumin Nanoformulations and Their Implications In Pcmentioning

confidence: 99%

Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention

et al. 2021

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Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in recent decades are focused on investigating the anti-tumor effects of natural compounds in PC. Curcumin is widely recognized and now of huge prestige for its anti-proliferative abilities in different types of cancer. However, its limited solubility, compatibility, and instability in the aqueous phase are major hurdles when administering. Nanoformulations have proven to be an excellent drug delivery system for various drugs and can be used as potential delivery platforms for curcumin in PC. In this review, a shed light is given on the miRNAs-mediated regulation of androgen receptor (AR) signaling and miRNA-curcumin interplay in PC, as well as on curcumin-based nanoformulations that can be used as possible therapeutic solutions for PC.

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Recent Patents, Formulation Techniques, Classification and Characterization of Liposomes

Cited by 43 publications

References 50 publications

Gene Therapy in Cancer Treatment: Why Go Nano?

Gene Therapy in Cancer Treatment: Why Go Nano?

Advanced Biomimetic Nanomaterials for Non-invasive Disease Diagnosis

Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention

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