Recent life events and obsessive–compulsive disorder (OCD): the role of pregnancy/delivery

Maina, Giuseppe; Albert, Umberto; Bogetto, Filippo; Vaschetto, P.; Ravizza, L.

doi:10.1016/s0165-1781(99)00090-6

Cited by 165 publications

(110 citation statements)

References 16 publications

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“…126 Another interesting observation is that the rates of OCD among new mothers is substantially higher than rates among the population and vary from 11 to 47%. [127][128][129][130][131] Most of these cases begin during late pregnancy or a few days to 2 weeks after delivery and involve intrusive worries of the mother doing harm to the newborn. Indeed, there are even anecdotal reports that new fathers may also be at increased risk.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…However, only a few studies have investigated the occurrence of stressful or potentially triggering events in the history of individuals with OCD. [127][128][129]131,136,137 Frequently reported precipitants include a recent move, sexual or marital problems and the illness or death of a near relative. [127][128][129] However, these studies have methodological weaknesses such as assessment of event occurrence without reliable and valid schedules, investigation of ill-defined premorbid study periods and absence of comparison groups.…”

Section: Environmental Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Obsessive-compulsive disorder phenotypes: implications for genetic studies

et al. 2004

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Obsessive-compulsive disorder (OCD) clinical presentation is remarkably diverse, and can vary both within and across patients over time. This variability in the phenotypic expression has led to the hypothesis that OCD is a heterogeneous disorder and that this heterogeneity obscures the findings of clinical, natural history and treatment response studies and complicates the search for vulnerability genes. A complete understanding of what comprises OCD and the underlying etiological mechanisms will require a dramatic change in how the disorder is conceptualized. In this review, several different approaches that may represent the first steps in this reconceptualization are discussed. These approaches include (1) narrowing the phenotype to identify categorically defined more homogeneous and mutually exclusive subtypes of OCD, (2) considering OC symptom dimensions as quantitative components of the more complex OCD phenotype and (3) broadening the phenotype to include other etiologically related conditions. A combined dimensional approach within distinctive subgroups is proposed as probably the most effective in helping to identify the heritable components of OCD. By identifying heritable components of OCD, it should be possible to find genes for these separate components. The review continues with the illustration of the possible role of some epigenetic risk and protective factors in the OCD presentation and the relevance of examining associated traits and/or endophenotypes to enhance our ability to understand the genetic basis of OCD. To conclude, we discuss the variability in treatment outcome and the significance of the development of specific pharmacological and/or behavioral based therapies tailored to each of these phenotypes. Molecular Psychiatry (2005) 10, 258-275.

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Section: Environmental Factorsmentioning

confidence: 99%

Section: Environmental Factorsmentioning

confidence: 99%

Obsessive-compulsive disorder phenotypes: implications for genetic studies

et al. 2004

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“…Buttolph and Holland 37 reported that OCD symptoms in 39 women increased in the postpartum period in 4 women (10%) after the birth of a first child and in 2 women (5%) after the birth of a subsequent child. Another study 76 assessed the occurrence of potentially traumatizing life events among patients with OCD. When examining types of stressful life events, women with OCD were found to be more likely than normal women subjects to report exposure to postpartum events, and high rates of obstetric complications were observed in these patients.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

“…These findings confirm that the postpartum period represents a risk factor for OCD in some individuals and suggest that obstetric complications may be relevant to the development of OCD. 76 …”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

An Update on Mood and Anxiety Disorders During Pregnancy and the Postpartum Period

Altshuler¹,

Hendrick²,

Cohen³

2000

Prim. Care Companion CNS Disord.

119

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“…Há vários estudos retrospectivos que têm verificado que o puerpério é o principal evento de vida relacionado ao desencadeamento ou à exacerbação do transtorno obsessivo-compulsivo (TOC), provavelmente devido às alterações hormonais e psicossociais próprias desse período [85][86][87][88][89] . Mas ainda poucos estudos estimam a prevalência do TOC especificamente no pós-parto.…”

Section: Transtorno Obsessivo-compulsivo (Toc)unclassified

Transtornos psiquiátricos no pós-parto

Cantilino¹,

Zambaldi²,

Sougey³

et al. 2010

Rev. psiquiatr. clín.

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ResumoObjetivo: O pós-parto é um período de alterações biológicas, psicológicas e sociais. Essa é considerada a época mais vulnerável para a ocorrência de transtornos psiquiátricos. A disforia puerperal, a depressão pós-parto e a psicose pós-parto têm sido classicamente relacionadas ao pós-parto. Atualmente, tem sido observado que os transtornos ansiosos também estão associados a esse período. Método: Neste artigo é feita uma revisão da bibliografia acerca de transtornos psiquiátricos no pós-parto a partir de artigos encontrados no PubMed e no SciELO entre os anos de 2000 e 2009. Livros, teses e outros artigos considerados relevantes citados no material consultado também foram incluídos. Resultados: A disforia puerperal ocorre em 50% a 85% das mulheres, o quadro é leve e transitório e não requer tratamento. A depressão pós-parto tem prevalência em torno de 13%, pode causar repercussões negativas na interação mãe-bebê e em outros aspectos da vida da mulher e deve ser tratada. A psicose pós-parto é rara, aparecendo em cerca de 0,2% das puérperas. Tem quadro grave que envolve sintomas psicóticos e afetivos, havendo risco de suicídio e infanticídio e geralmente requerendo internação hospitalar. Os transtornos ansiosos podem ser exacerbados ou precipitados no pós-parto, especialmente o transtorno de ansiedade generalizada, o transtorno de estresse pós-traumático e o transtorno obsessivo-compulsivo. Conclusão: Apesar de não serem reconhecidos como entidades diagnósticas pelos sistemas classificatórios atuais, os transtornos mentais no puerpério apresentam peculiaridades clínicas que merecem atenção por parte de clínicos e pesquisadores.Cantilino A, et al. / Rev Psiq Clín. 2010;37(6):278-84 Palavras-chave: Transtornos psiquiátricos, pós-parto, depressão, ansiedade, psicose. AbstractObjective: The postpartum period is marked by biological, psychological and social changes. Women are considered most susceptible to psychiatric disorders during the postpartum period. Puerperal blues, postpartum depression and postpartum psychosis have been classically associated to the postpartum. Anxiety disorders have also recently been associated to this period. Method: The present article reports a review of the literature on postpartum psychiatric disorders based on articles found on the PubMed and SciELO databases, published between 2000 and 2009. Relevant books, theses and other articles cited in the articles found were also included in this review. Results: Puerperal dysphoria occurs in 50% to 85% of women following childbirth and is typically mild and transient in nature and requires no treatment. Postpartum depression has a prevalence rate of around 13% and can have negative repercussions on mother-infant interaction and other life events and must therefore be treated. Postpartum psychosis is rare, occurring in approximately 0.2% of puerperium cases. This condition is severe with psychotic and affective symptoms as well as risk of suicide and infanticide. Postpartum psychosis patients generally require hospital treatment. Anxi...

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Recent life events and obsessive–compulsive disorder (OCD): the role of pregnancy/delivery

Cited by 165 publications

References 16 publications

Obsessive-compulsive disorder phenotypes: implications for genetic studies

Obsessive-compulsive disorder phenotypes: implications for genetic studies

An Update on Mood and Anxiety Disorders During Pregnancy and the Postpartum Period

Transtornos psiquiátricos no pós-parto

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