Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation

Shin, Minsang; Kang, Hye Suk; Park, Jae Hyung; Bae, Jae Hoon; Song, Dong Hyun; Im, Seung Soon

doi:10.3803/enm.2017.32.1.11

Cited by 28 publications

(12 citation statements)

References 30 publications

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“…IGFBP-2 has been suggested as a biomarker for metabolic diseases, such as diabetes and insulin resistance [33]. In our study, IGFBP-2 concentrations were until 6-fold higher in patients, compared with controls.…”

Section: Discussionsupporting

confidence: 48%

Noninvasive Biomarkers for the Diagnosis of Liver Fibrosis and Cirrhosis

Rosique-Oramas¹,

Martínez-Castillo²,

Guzmán³

et al. 2019

Liver Cirrhosis - Debates and Current Challenges

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The clinical importance of monitoring liver fibrosis lies in the morbidity and mortality of the chronic liver diseases in relation to the stage and progression of fibrosis. Whether the fibrosis stabilizes or regresses depends on the specific treatment. Liver biopsy, the current standard for the diagnosis, has implicit limitations due to sampling heterogeneity. There are noninvasive imaging methods, such as transient elastography that measures the stiffness of the liver, but it has some limitations (feasibility and unreliability), particularly in obese patients. FibroTest is the most widely used noninvasive serological method worldwide which is efficacious in the extreme stages of fibrosis, but these methods cannot discern intermediate stages. Liver fibrosis is a dynamic response that involves multiple cellular and molecular events with an excessive deposit of extracellular matrix. Even though there is much information on the pathophysiology of fibrosis, that knowledge is still incomplete, greatly hindering the development of both an accurate treatment and a noninvasive diagnostic method with adequate sensitivity for all the stages of fibrosis. It is known that IGFBP participates in liver homeostasis, and thus these proteins can be used as serum biomarkers during the progression of liver fibrosis in chronic hepatitis C.

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Section: Discussionsupporting

confidence: 48%

Noninvasive Biomarkers for the Diagnosis of Liver Fibrosis and Cirrhosis

Rosique-Oramas¹,

Martínez-Castillo²,

Guzmán³

et al. 2019

Liver Cirrhosis - Debates and Current Challenges

View full text Add to dashboard Cite

show abstract

“…In mammals, Igfbp-2 is highly expressed during embryonic stages, and more lowly expressed in adult tissues, with highest levels in liver, adipocytes, the central nervous and reproductive systems, heart, and kidney ( 75 ). Mice embryos overexpressing Igfbp-2 show a reduced growth rate, likely through reduced Igf availability ( 76 ).…”

Section: Physiological Roles Of Teleost Igfbpsmentioning

confidence: 99%

Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

serrana

Macqueen

2018

Front. Endocrinol.

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The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation—with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.

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“…Medical interventions focusing on increasing caloric intake fail to counteract wasting (Fearon et al, 2012;Op den Kamp et al, 2009). Importantly, clinical work in humans has shown that cachexia and other disease conditions are associated with elevated levels of IGFBPs (Baxter, 2014;Huang et al, 2016;Shin et al, 2017).…”

Section: Insulin Signalingmentioning

confidence: 99%

Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death

Wang

Ragsdale

2018

Journal of Experimental Biology

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Post-reproductive life in the female octopus is characterized by an extreme pattern of maternal care: the mother cares for her clutch of eggs without feeding until her death. These maternal behaviors are eradicated if the optic glands, the octopus analog of the vertebrate pituitary gland, are removed from brooding females. Despite the optic gland's importance in regulating maternal behavior, the molecular features underlying optic gland function are unknown. Here, we identify major signaling systems of the optic gland. Through behavioral analyses and transcriptome sequencing, we report that the optic gland undergoes remarkable molecular changes that coincide with transitions between behavioral stages. These include the dramatic upregulation and downregulation of catecholamine, steroid, insulin and feeding peptide pathways. Transcriptome analyses in other tissues demonstrate that these molecular changes are not generalized markers of senescence, but instead, specific features of the optic glands. Our study expands the classic optic gland-pituitary gland analogy and more specifically, it indicates that, rather than a single 'self-destruct' hormone, the maternal optic glands employ multiple pathways as systemic hormonal signals of behavioral regulation.

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Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation

Cited by 28 publications

References 30 publications

Noninvasive Biomarkers for the Diagnosis of Liver Fibrosis and Cirrhosis

Noninvasive Biomarkers for the Diagnosis of Liver Fibrosis and Cirrhosis

Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death

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