Recent discoveries of anticancer flavonoids

Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Plescia, Fulvio; Daidone, Giuseppe

doi:10.1016/j.ejmech.2017.07.034

Cited by 299 publications

(182 citation statements)

References 80 publications

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“…The flavonoid compounds, one of the secondary metabolites, are crucial constituents due to the active hydroxyl groups (39). In this study, the results of total flavonoid were found to range from 9.22 ± 0.92 mg QEE/g dry weight to 1.40 ± 0.02 mg QE/g dry weight.…”

Section: Discussionmentioning

confidence: 73%

Investigation of antioxidant, α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of Vaccinium arctostaphylos L.

Barut¹,

Barut²,

Engin³

et al. 2018

tjps

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GİRİŞ ve AMAÇ:Bu çalışmanın amacı Vaccinium arctostaphylos (V. arctostaphylos) L.'den hazırlanan etanol (EE), metanol (ME) ve su (AE) ekstraktlarının toplam fenolik, antosiyanin, flavonoit içerikleri ve biyolojik özelliklerinin incelenmesidir. YÖNTEM ve GEREÇLER: V. arctostaphylos'un EE, ME ve AE ekstraktları hazırlandı. Bu ekstraktların total fenolik, antosiyanin ve flavonoid içerikleri, antioksidan (DPPH, metal iyon şelatlama ve FRAP metotları), α-glukozidaz, anti-inflamatuvar ve DNA koruma özellikleri araştırılmıştır. BULGULAR: EE, 44.42 ± 1.22 mg GAE/g kuru ağırlık, 8.46 ± 0.49 mg/CGE/g kuru ağırlık ve 9.22 ± 0.92 mg QEE/g kuru ağırlık değerleriyle en yüksek toplam fenolik, antosiyanin ve flavonoid içeriğine sahip olduğu görülmüştür. Bununla birlikte ekstraktların antioksidan aktiviteleri sırasıyla EE > ME > AE olduğu belirlendi. EE ve ME α-glukozidaz enzimini sırasıyla 0.301 ± 0.002 mg/mL ve 0.477 ± 0.003 mg/mL IC50 değerleriyle inhibe etmiştir. Ayrıca, EE ve ME'nin inhibisyon sabiti (Ki) değerleri 0.48 ± 0.02 mg/mL ve 0.46 ± 0.01 mg/mL bulunarak, yarışmasız inhibisyon gerçekleştirdikleri belirlenmiştir. EE'nin 100 ve 300 mg/kg dozları farelerde formalin ile indüklenen ödemi önemli derecede azalttığı belirlenmiştir. DNA koruma çalışmalarında, ekstraktlar radikal süpürme aktivitesinden dolayı Fenton reaktifiyle oluşturulan hasara karşı süpersarmal plasmid pBR322 DNA'yı korumuştur. TARTIŞMA ve SONUÇ: Sonuçlarımız, V. arctostaphylos L.'nin EE'sinin güçlü antioksidan, anti-inflamatuar, α-glukozidaz inhibisyon ve DNA koruyucu etkilere sahip olduğunu göstermiştir; bu, oksidatif hasar ve iltihaplanma ile ilişkili hastalıkları önlemek veya tedavi etmek için etkili bir tıbbi bitki olabileceğini düşündürmektedir.Anahtar Kelimeler: antioksidan, anti-inflamatuvar, DNA, α, -glukozidaz, V. arctostaphylos. INTRODUCTION:The scope of this study was to investigate total phenolic, anthocyanin, flavonoid contents and biological properties of ethanol extract (EE), methanol extract (ME) and aqueous extract (AE) from Vaccinium arctostaphylos (V. arctostaphylos) L. METHODS: EE, ME and AE of V. arctostaphylos were prepared. Various biological activities such as total phenolic, anthocyanin and flavonoid contents, antioxidant (DPPH, u n c o r r e c t e d p r o o f ferrous ion-chelating and FRAP assays), α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of these extracts were studied. RESULTS: EE exhibited the highest total phenolic, anthocyanin and flavonoid contents with 44.42 ± 1.22 mg GAE/g dry weight, 8.46 ± 0.49 mg/CGE/g dry weight and 9.22 ± 0.92 mg QEE/g dry weight, respectively. The antioxidant activities of extracts followed order: EE > ME > AE. EE and ME inhibited α-glucosidase enzyme and their IC50 values were 0.301 ± 0.002 mg/mL and 0.477 ± 0.003 mg/mL respectively. In addition, EE and ME were determined as noncompetitive inhibitor with the inhibitory constant (Ki) values of 0.48 ± 0.02 mg/mL and 0.46 ± 0.01 mg/mL. 100 and 300 mg/kg doses of EE caused a significant reduction in formalin-induced ede...

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Section: Discussionmentioning

confidence: 73%

Investigation of antioxidant, α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of Vaccinium arctostaphylos L.

Barut¹,

Barut²,

Engin³

et al. 2018

tjps

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“…There are many reports on biological activities of phenolic acids, coumarins and flavonoids, chlorogenic acid and derivatives have multiple properties including anti-inflammatory [06], antispasmodic [35], inhibition of the HIV-1 integrase [36], antibacterial and antioxidant [07]. In the same context, therapeutic potencies of flavonoids and coumarins as antioxidant, cardiovascular disease protection, vascular fragility, antinflammatory, neurodegenerative diseases prevention and anti-platelet aggregation were widely published [8].…”

Section: Discussionmentioning

confidence: 99%

“…Phenolics are one of the most groups of phytochemicals studied in recent times due to their high and various biological activities. Phenolic acids, flavonoids, coumarins, stilbens, lignans, tanins and more of other phenolic compounds have been found to exhibit properties as anti-hypertensive, anti-inflammatory, antiproliferative, anticarcinogenic, antimicrobial and antioxidants [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD profiling and antioxidant activity of the n-butanol extract from aerial parts of Algerian Crithmum maritimum L.

Boutellaa

Zellagui

Öztürk

et al. 2019

Acta Scientifica Naturalis

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In this study, phenolic compounds from Crithmum maritimum L. n-butanol soluble fraction were quantified and identified spectrophotometrically and by using HPLC-DAD technics. They equally investigated for their antioxidant potential utilizing six in vitro assays: DPPH • , ABTS •+ , O 2 •-, Bleaching of β-carotene in linoleic acid, CUPRAC and Ferric reducing power. High amounts of total phenolics and flavonoids were recorded: 161.57± 0.479 µg GA eq .mg -1 and 31.56± 0.291 µg Q eq .mg -1 respectively. Nine compounds among them hydroxicinnamic acid and hydroxybenzoic acid derivatives, coumarins and flavonoids were identified. Chlorogenic acid known for their various pharmacological properties was detected as major compound of the extract. Rutin, vanillin, ellagic acid, ferrulic acid,6,7 dihydroxy coumarin, methyl 1,4 benzoquinone and trans-cinnamic acid were also detected. The extract was found to exhibit strong antioxidant capacities in all systems. Based on these results, it is right to conclude the n-butanol extract is promising source of natural antioxidants.Atlantic coast [9,11]. In Algeria, the genus Crithmum is represented by only the species C.maritimum L. [12]. Researches on this species demonstrated the presence of essential oils [11], phenolic compounds [13][14][15][16], Vitamins and minerals [17,18], proteins and amino acids [19] and fatty acids [20].The soluble phenolic constituents of the n-butanol fraction from C. maritimum L. have not been studied previously. The present research aimed to identify and quantified phenolic components present in the n-butanol extract from aerial parts of C.maritimum L. in full flowering stage using Folin Ciocalteu, aluminum chloride and HPLC-DAD analysis and to determine their antioxidant potential by different methods: DPPH • , ABTS •+ and O 2•scavenging, lipid peroxidation, ferric reducing power and CUPRAC. Material and methods Plant materialAerial parts of marine fennel (Crithmum maritimum L.) were collected in August 2016 at full flowering stage, in the region of Jijel North eastern of Algeria (36°47′16.33″ N Lat., 5°38′53.45″ E Long. and 3 m altitude). A voucher specimen (ZA / 144) was deposited at the laboratory of Biomolecules and Plant Breeding, FeCl 3 (0.1%) were added to the mixture. Absorbance was measured at 700 against a blank (methanol). Results were given as absorbance and compared with those of BHT and BHA used as positive controls. Cupric reducing capacity (CUPRAC)The cupric reducing antioxidant capacity was determined using the method of Apak et al.[30] modified by Öztürk et al. [31] A mixture constituted for 60 µL ammonium acetate buffer (1M, pH 7.0), 50 µL of 7.5 mM neocuproin and 50 µL 10 mM (Cu Cl 2 , 2H 2 O) was prepared and then 40 µL of sample solution at concentrations (6.25-200) µg/mL was added to the initial mixture. After one hour of incubation at room temperature, the absorbance at 450 nm was read against a blank reagent. Standard antioxidants used in this test were BHT and BHA. Results were given as absorbance and A 0.5 (µg/mL) values cor...

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“…It is found in abundance in onions, apples, broccoli and berries. Flavonoid is involved in the scavenging of oxygen derived free radicals [63], and is also a potent hypolipidemic agent [64]. They possess a high antioxidant potential due to their hydroxyl groups and protect efficiently against diseases like arteriosclerosis [65] [66].…”

Section: Active Secondary Metabolitesmentioning

confidence: 99%

Naturally Derived Formulations and Prospects towards Cancer

Masarkar¹,

Mukherjee²,

Goel³

et al. 2019

Health

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Traditional Medicine (TM) and their secondary metabolites are being increasingly recognized as useful complementary treatments toward the cancer. A large number of clinical studies have reported and proven concern of cancer patients. Here we have also reported recent studies on the biochemical and cellular mechanisms of Traditional Medicine (TM). Nowadays, Chemotherapy and surgery are standard methods for treatment of cancer, but still it's not been fully successful. Some progress has been made in cancer diagnosis and treatment, but high incidence rate of cancer and low survival rate of patient are still being reported worldwide. Since ancient times, a number of traditional medicines known as Ayurveda, Siddha, Unani, Iranian, Chinese, Korean, acupuncture, Muti, Ifa, and African medicine are widely used for therapeutic purposes and are becoming popular as Traditional Medicine (TM). It has been reported that plants synthesize plethora of "secondary metabolites" or "phytochemicals", proven to possess anti-mutagenic and anti-cancer properties in many research studies. There are many possibilities for further organized research for screening of medicinal plants for their potential and efficacy against chronic diseases such as a cancer and other inflammatory diseases. Therefore, researcher's interest should be in identification and standardization of new anti-cancer drug with low side effects and greater efficacy, that is easily acceptable in medical community and which may overcome the challenges in present and future cancer therapy. This review explores therapeutic value of certain bio-active principals of plant which could serve as potential pharmacologically active drug for treatment of cancer in future.

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Recent discoveries of anticancer flavonoids

Cited by 299 publications

References 80 publications

Investigation of antioxidant, α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of Vaccinium arctostaphylos L.

Investigation of antioxidant, α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of Vaccinium arctostaphylos L.

HPLC-DAD profiling and antioxidant activity of the n-butanol extract from aerial parts of Algerian Crithmum maritimum L.

Naturally Derived Formulations and Prospects towards Cancer

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