Investigation of antioxidant, α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of Vaccinium arctostaphylos L.

Barut, Burak; Barut, Elif Nur; Engin, Seçkin; Özel, Arzu; Sezen, Feride Sena

doi:10.4274/tjps.28247

Cited by 5 publications

(8 citation statements)

References 39 publications

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“…Although numerous NPs have been successfully manufactured utilizing biological agents (microorganisms and plants), the development of novel NPs with biological, physical, and chemical properties is still at the cutting‐edge of nanotechnology research. Fruit extract of V. arctostaphylos L. has a noteworthy amount of anthocyanins with widely beneficial effects that are used in several preparations of traditional medicine due to its rich antioxidant, inflammatory, and antihyperlipidemia properties (Barut et al, 2019; Mohtashami et al, 2019). In this study, we introduced an efficient and green approach to the synthesis of SeNPs using fruit extract of V. arctostaphylos L.…”

Section: Discussionmentioning

confidence: 99%

Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer

Gharbavi

Mousavi

Pour-Karim

et al. 2022

Cell Biology International

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Biogenic synthesis of selenium nanoparticles (SeNPs) using plant extracts has emerged as a promising alternative approach to traditional chemical synthesis. The current study aims to introduce a safe, low-cost, and green synthesis of SeNPs using fresh fruit extract of Vaccinium arctostaphylos L. The biogenic synthesis of SeNPs was confirmed by different analyses including ultraviolet-visible spectrophotometry, Fourier transform infrared, and energy-dispersive X-ray. Also, the crystalline nature, size, and morphology of the obtained SeNPs were characterized by X-ray diffraction, dynamic light scattering, field emission scanning electron microscopy, and transmission electron microscopy techniques. The SeNPs were successfully synthesized with fruit extract of V. arctostaphylos L. in a regular spherical form and narrow size distribution with suitable zeta-potential values and exhibited appropriate biocompatibility. It revealed that the synthesized SeNPs can significantly inhibit the growth of 4T1 breast cancer cells with an IC 50 of ∼84.19 ± 25.96 µg/ml after 72 h treatment. Overall, it can be concluded that the green synthesized SeNPs can be attractive, nontoxic, and eco-friendly candidates for drug delivery or medicinal applications.

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Section: Discussionmentioning

confidence: 99%

Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer

Gharbavi

Mousavi

Pour-Karim

et al. 2022

Cell Biology International

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“…In this work, the mixture containing 50 mM Tris-HCl (pH 7.0), plasmid DNA, FeSO 4 (1 mM), H 2 O 2 (2 % (v/v)), and polydatin at 12.5, 25, 50 and 100 μM were treated at 37 °C for 1 h. The electrophoresis experiments were carried out as detailed above. [33]…”

Section: Supercoiled Pbr322 Plasmid Dna Hydrolytic Nuclease Effectsmentioning

confidence: 99%

In Vitro and in Silico Investigation of DNA Interaction, Topoisomerase I and II Inhibitory Properties of Polydatin

Şöhretoğlu

Barut

Sarı

et al. 2022

Chemistry & Biodiversity

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Polydatin or piceid, is the 3-O-glucoside of resveratrol and is found abundantly in grapes, peanuts, wine, beer, and cacao products. Although anticancer activity of polydatin was reported before, and potential antiproliferative mechanisms of polydatin have been proposed, its direct effects on DNA and inhibitory potential against topoisomerase enzymes have remained unknown. In this study we aimed to reveal the link between polydatin's effects on DNA and DNA-topoisomerases and its antiproliferative promise. For this purpose, we evaluated the effects of polydatin on DNA and DNA topoisomerase using in vitro and in silico techniques. Polydatin was found to protect DNA against Fenton reaction-induced damage while not showing any hydrolytic nuclease effect. Further, polydatin inhibited topoisomerase II but not topoisomerase I. According to molecular docking studies, polydatin preferably showed minor groove binding to DNA where the stilbene moiety was important for binding to the DNA-topoisomerase II complex. As a result, topoisomerase II inhibition might be another anticancer mechanism of polydatin.

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“…The inhibitory properties of the compounds on α-glucosidase were investigated according to our previously reported methods [31]. The results were expressed as IC 50 values.…”

Section: α-Glucosidase Inhibitory Properties Of the Compoundsmentioning

confidence: 99%

Pyridine substituted BODIPYs: synthesis, characterization and cholinesterease, α-glucosidase inhibitory, DNA hydrolytic cleavage effects

Barut¹,

Baş²,

Bıyıklıoğlu³

2021

Turk J Chem

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In this study, the synthesis of new monostyryl (BDPY-2) and distyryl BODIPY dyes (BDPY-4, BDPY-5) containing pyridine groups to has been reported for the first time. The acetylcholinesterase from Electrophorus electricus (AChE), butyrylcholinesterase from equine serum (BuChE), α-glucosidase from Saccharomyces cerevisiae and DNA hydrolytic cleavage actions of BDPY-2, BDPY-4, BDPY-5 were investigated using various techniques.The results indicated that the compounds had varying inhibition properties against AChE, BuChE, and α-glucosidase. BDPY-4 was the most potent compound on AChE with IC 50 of 54.78 ± 4.51 µM and Lineweaver-Burk plots indicated that the compound is bound to a site other than the active site as a noncompetitive inhibitor. The compound-protein binding experiment showed that BDPY-4 changed the microenvironment around AChE. On the other hand, the compounds showed lower α-glucosidase inhibition than the positive control. The DNA hydrolytic cleavage effects were not observed on supercoiled plasmid DNA in the presence of the compounds as compared to negative controls. These findings results suggested that BDPY-4 might be a promising compound to treat Alzheimer's diseases.

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Investigation of antioxidant, α-glucosidase inhibitory, anti-inflammatory and DNA protective properties of Vaccinium arctostaphylos L.

Cited by 5 publications

References 39 publications

Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer

Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer

In Vitro and in Silico Investigation of DNA Interaction, Topoisomerase I and II Inhibitory Properties of Polydatin

Pyridine substituted BODIPYs: synthesis, characterization and cholinesterease, α-glucosidase inhibitory, DNA hydrolytic cleavage effects

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