Recent developments on gold nanostructures for surface enhanced Raman spectroscopy: Particle shape, substrates and analytical applications. A review

López‐Lorente, Ángela I.

doi:10.1016/j.aca.2021.338474

Cited by 77 publications

(46 citation statements)

References 197 publications

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“…Even though this method is less easy than the previous one, using this technique one can still fabricate the plasmon active substrate without capping agents, which allows an easier functionalization of nanoparticles [19]. [6], (b) e-beam lithography [32], (c) soft lithography [33].…”

Section: Sers Substrates Used For Biosensingmentioning

confidence: 99%

“…The SERS substrate can be optimized for the near-infrared excitation laser, thus avoiding auto-fluorescence from biological samples and minimizing their photo damage. Within the group of noble metal nanostructures, gold-based nanostructures or gold nanoparticles (AuNPs) are mostly used for biosensing applications due to their biocompatibility, tunability, their unique optical and electronic properties, together with their nontoxic nature when compared to other nanomaterials, such as metal oxides or carbon-based nanomaterials in general [6][7][8]. As a result, there have been several impressive developments and applications of SERS active gold nanostructures for biosensing applications [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Figure 2. Scheme of the different procedures of SERS substrate fabrication, (a) nanoparticles in suspension and immobilized on the solid substrate[6], (b) e-beam lithography[32], (c) soft lithography[33].…”

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confidence: 99%

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Biosensing Using SERS Active Gold Nanostructures

et al. 2021

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Surface-enhanced Raman spectroscopy (SERS) has become a powerful tool for biosensing applications owing to its fingerprint recognition, high sensitivity, multiplex detection, and biocompatibility. This review provides an overview of the most significant aspects of SERS for biomedical and biosensing applications. We first introduced the mechanisms at the basis of the SERS amplifications: electromagnetic and chemical enhancement. We then illustrated several types of substrates and fabrication methods, with a focus on gold-based nanostructures. We further analyzed the relevant factors for the characterization of the SERS sensor performances, including sensitivity, reproducibility, stability, sensor configuration (direct or indirect), and nanotoxicity. Finally, a representative selection of applications in the biomedical field is provided.

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Section: Sers Substrates Used For Biosensingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biosensing Using SERS Active Gold Nanostructures

et al. 2021

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“…It is highly sensitive and can be used for single molecule detection and resistant to photobleaching and photodegradation. Besides, it is suitable for long-term monitoring ( Zhao et al, 2021a ; Lopez-Lorente, 2021 ). SERS technology is widely used in various biomedical fields, such as nucleic acid, protein, human cells, human tissues and human body fluids ( Calderon et al, 2021 ; Ma et al, 2021 ; Xi and Liang, 2021 ), and has important applications in the diagnosis of tumors ( Guerrini et al, 2021 ; Shen et al, 2021 ; Sun et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Yang

Jia

2022

Front. Bioeng. Biotechnol.

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Exosomes are small nanoscale vesicles with a double-layered lipid membrane structure secreted by cells, and almost all types of cells can secrete exosomes. Exosomes carry a variety of biologically active contents such as nucleic acids and proteins, and play an important role not only in intercellular information exchange and signal transduction, but also in various pathophysiological processes in the human body. Surface-enhanced Raman Spectroscopy (SERS) uses light to interact with nanostructured materials such as gold and silver to produce a strong surface plasmon resonance effect, which can significantly enhance the Raman signal of molecules adsorbed on the surface of nanostructures to obtain a rich fingerprint of the sample itself or Raman probe molecules with ultra-sensitivity. The unique advantages of SERS, such as non-invasive and high sensitivity, good selectivity, fast analysis speed, and low water interference, make it a promising technology for life science and clinical testing applications. In this paper, we briefly introduce exosomes and the current main detection methods. We also describe the basic principles of SERS and the progress of the application of unlabeled and labeled SERS in exosome detection. This paper also summarizes the value of SERS-based exosome assays for early tumor diagnosis.

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“…While the light is focused on different areas of the SERS substrate such as A, B, C and D, the different numbers of nanoparticles are contained within the illuminated area and the definition of the duty cycle of nanostructures is used to describe this situation. The enhanced effect is related to the nanostructures [38][39][40], so different enhancement effects are obtained while the exciting light is irradiated at different places. Hence, we should consider the effect of the duty cycle of nanostructures on the spectral enhancement effect.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Duty Cycle of Flower-like Silver Nanostructures Fabricated with a Lyotropic Liquid Crystal on the SERS Spectrum

et al. 2021

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Surface-enhanced Raman scattering (SERS) has been widely reported to improve the sensitivity of Raman spectra. Ordinarily, the laser is focused on the sample to measure the Raman spectrum. The size of the focused light spot is comparable with that of micro-nano structures, and the number of micro-nano structures contained in the light spot area (defined as duty cycle) will severely affect the spectrum intensity. In this study, flower-like silver nanostructures were fabricated with a soft lyotropic liquid crystal template in order to investigate the effect of duty cycle. They were observed under a scanning electron microscope, and their spectrum enhancement factor was computed with the obtained Raman spectrum. Then, their duty cycles were measured using a SERS substrate at different locations. A formula was derived to represent the relation between the duty cycle of the nanoflowers and the Raman spectral intensity. This work could promote the actual applications of SERS in high-sensitivity spectrum testing.

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Recent developments on gold nanostructures for surface enhanced Raman spectroscopy: Particle shape, substrates and analytical applications. A review

Cited by 77 publications

References 197 publications

Biosensing Using SERS Active Gold Nanostructures

Biosensing Using SERS Active Gold Nanostructures

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Effect of the Duty Cycle of Flower-like Silver Nanostructures Fabricated with a Lyotropic Liquid Crystal on the SERS Spectrum

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