Recent developments of metal N-heterocyclic carbenes as anticancer agents

Aher, Sainath Babaji; Muskawar, Prashant Narayan; Thenmozhi, Kathavarayan; Bhagat, Pundlik Rambhau

doi:10.1016/j.ejmech.2014.05.036

Cited by 120 publications

(62 citation statements)

References 65 publications

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“…近些年来, 有关金络合物超分子抗癌作用的研究主要集中在金的唑类氮杂环卡宾(NHC)方面 [70,71] . 金属氮杂环卡宾能够抑制硫氧还蛋白还原酶(Thioredoxin reductase, TrxR)和其它蛋白质的活性导致癌细胞死亡 [72] , 因此, 构建基于氮杂环卡宾的金属超分子对抗癌药物的研发有重要意义.…”

Section: 金类唑超分子作为抗癌药物unclassified

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Cheng¹,

Wang²,

Addla³

et al. 2016

Chin. J. Org. Chem.

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Noncovalent bond forces-based supramolecular chemistry grows quite rapidly and has been revealed to have extensively potential applications and huge development values in chemistry, physics, materials and information science, medicine and so on. Azole compounds such as imidazoles, thiazoles, oxazoles, pyrazoles, triazoles, tetrazoles and carbazoles containing special nitrogen aromatic heterocyclic structure, can exert non-covalent forces to form supramolecular complexes with inorganic and/or organic compounds and exhibit broad biological activity. In recent years, heterocyclic azole-based supramolecular complexes have been expeditiously expanding in the field of medicine, and have become a quite hot topic. Combined with our work and referring to other literature in recent 5 years, this paper systematically reviews the researches and applications of azole-based supermolecules as medicinal agents including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, anti-inflammatory drugs and other ones. Finally, the perspectives of the future development of azole-based supermolecules as medicinal agents are also presented.

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Section: 金类唑超分子作为抗癌药物unclassified

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Cheng¹,

Wang²,

Addla³

et al. 2016

Chin. J. Org. Chem.

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“…These drawbacks limit the use and efficiency of cisplatin and related Pt(II) complexes in cancer therapy [3][4][5]. These considerations have stimulated the search for new non-platinum anticancer agents that possess reduced side effects, lower resistance, lower cost and greater efficacy toward a wider range of cancers [6,7]. Hence, in the past few decades, transition metal complexes have been extensively studied as anticancer and antibacterial agents [8,9].…”

Section: Introductionmentioning

confidence: 99%

Syntheses, crystal structures and in vitro anticancer activities of oxovanadium(IV) complexes of amino acid Schiff base and 1,10-phenanthroline ligands

Cao

et al. 2016

Transit Met Chem

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Four oxovanadium(IV) complexes, namely [VO(desa-met)(phen)]ÁMeOHÁ2H 2 O (1) (desa-met = Schiff base derived from 4-(diethylamino)salicylaldehyde and DLmethionine, phen = 1,10-phenanthroline), [VO(o-van-met)-(phen)]ÁMeOHÁCH 2 Cl 2 Á3H 2 O (2) (o-van-met = Schiff base derived from o-vanillin and DL-methionine), [VO(dtbsnapa)(phen)]Á2H 2 O (3) (dtbs-napa = Schiff base derived from 3,5-di-tert-butyl salicylaldehyde and 3-(1-naphthyl)-Lalanine) and [VO(hyna-napa)(phen)]Á1.5H 2 O (4) (hynanapa = Schiff base derived from 2-hydroxy-1-naphthaldehyde and 3-(1-naphthyl)-L-alanine), were synthesized and characterized by IR, HRMS, UV-vis spectra, molar conductance and single-crystal X-ray diffraction (XRD). X-ray structural analysis showed that the V(IV) atoms in all four complexes are six-coordinated in a distorted octahedral environment. In the crystals of complexes 1 and 2, p-p stacking interactions together with hydrogen bonds connect the molecular units into 2D networks. Meanwhile, CH-p stacking interactions are observed between the aromatic rings in the crystals of 1 and 4, while the p-p stacking interactions between aromatic rings in the crystals of 2 and 3 are arranged with a face-to-face mode. The in vitro anticancer activities of these complexes against A-549 and HeGp2 cells were tested by MTT assay.

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“…14 Recent developments in inorganic drug discovery of metal NHCs, focus on coinage (Au, Ag, Cu) and platinum-group metals (Pt, Ru, Pd, Os, Ir) and their structure-activity relationships as well as biological targets are being elucidated. [15][16][17][18][19]20 The biological modes of action of antiproliferative NHC complexes have been investigated for several of these metal ions and led to the identification of different potential molecular targets. 12,[15][16][17][19][20][21][22][23] Among these mechanisms, cell cycle arrest and mitochondrial dysfunctions (e.g.…”

Section: Fig 1 -Structures Of Organometallic Compounds Used For Medimentioning

confidence: 99%

“…[15][16][17][18][19]20 The biological modes of action of antiproliferative NHC complexes have been investigated for several of these metal ions and led to the identification of different potential molecular targets. 12,[15][16][17][19][20][21][22][23] Among these mechanisms, cell cycle arrest and mitochondrial dysfunctions (e.g. ROS production, changes in mitochondrial membrane potential, cytochrome c release and caspase activation) may be responsible for triggering apoptosis in cancer cells and this is on the one hand caused by the interaction of such metal-based drug candidates with proteins.…”

Section: Fig 1 -Structures Of Organometallic Compounds Used For Medimentioning

confidence: 99%

On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging

et al. 2017

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Recent developments of metal N-heterocyclic carbenes as anticancer agents

Cited by 120 publications

References 65 publications

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Syntheses, crystal structures and in vitro anticancer activities of oxovanadium(IV) complexes of amino acid Schiff base and 1,10-phenanthroline ligands

On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging

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