Syntheses, crystal structures and in vitro anticancer activities of oxovanadium(IV) complexes of amino acid Schiff base and 1,10-phenanthroline ligands

Abstract

Four oxovanadium(IV) complexes, namely [VO(desa-met)(phen)]ÁMeOHÁ2H 2 O (1) (desa-met = Schiff base derived from 4-(diethylamino)salicylaldehyde and DLmethionine, phen = 1,10-phenanthroline), [VO(o-van-met)-(phen)]ÁMeOHÁCH 2 Cl 2 Á3H 2 O (2) (o-van-met = Schiff base derived from o-vanillin and DL-methionine), [VO(dtbsnapa)(phen)]Á2H 2 O (3) (dtbs-napa = Schiff base derived from 3,5-di-tert-butyl salicylaldehyde and 3-(1-naphthyl)-Lalanine) and [VO(hyna-napa)(phen)]Á1.5H 2 O (4) (hynanapa = Schiff base derived from 2-hydroxy-1-naphthaldehyde and 3-(1-naphthyl)-L-alanine), were synthesized and characterized by IR, HRMS, UV-vis spectra, molar conductance and single-crystal X-ray diffraction (XRD). X-ray structural analysis showed that the V(IV) atoms in all four complexes are six-coordinated in a distorted octahedral environment. In the crystals of complexes 1 and 2, p-p stacking interactions together with hydrogen bonds connect the molecular units into 2D networks. Meanwhile, CH-p stacking interactions are observed between the aromatic rings in the crystals of 1 and 4, while the p-p stacking interactions between aromatic rings in the crystals of 2 and 3 are arranged with a face-to-face mode. The in vitro anticancer activities of these complexes against A-549 and HeGp2 cells were tested by MTT assay.

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

“…This complex can be replaced with oxygen to form oxyhemoglobin and maintain normal physiological functions in organisms [ 25 ]. In addition, studies on the biological activities of essential metal complexes, such as antimicrobial, antiphlogistic, oxidation resisting, antidiabetic, and antineoplastic, have aroused the interest of scientific researchers [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

“…Only V‐33 and V‐34 were found to have weak anticancer activity towards A‐549 and Hep‐G2 cells with IC 50 values of 28.4 to 45.2 μmol L −1 . Furthermore, the activity of these complexes was shown to be lower than the cisplatin and VO(acac) 2 controls [94] (Figure 8, Table 6).…”

L-alanine Derived Schiff Base Ligated Vanadium(IV) Complex with Phenanthroline as Co-ligand: Synthesis, Crystal Structure and Hirshfeld Surface Analysis

“…2 The crystal structures of complexes involving the Schiff base derived from salicylaldehyde and amino acids revealed that the Schiff base ligands mainly act as tridentate ligands, coordinating through the phenolato oxygen, imine nitrogen and carboxylate oxygen. [3][4][5] Supramolecular architectures with coordination bonds, hydrogen bonds and π-π stacking interactions have received much attention for its prospective applications in the elds of host-guest chemistry, biochemistry, electronics, magnetism, optics, gas absorbent, catalysis and molecular recognition. [6][7][8][9] These interactions are becoming increasingly important in supramolecular chemistry and crystal engineering.…”