Recent developments of coumarin-containing derivatives and their anti-tubercular activity

Hu, Yuan‐Qiang; Xu, Zhi; Zhang, Shu; Wu, Xiang; Ding, Junwei; Lv, Ziquan; Feng, Lian‐Shun

doi:10.1016/j.ejmech.2017.05.004

Cited by 191 publications

(37 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This disease threatens the human life by affecting lungs primarily (pulmonary TB) distant from other vital organs. Drug-resistant TB (DR-TB), multidrugresistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and totally drug resistant TB (TDR) emerging nowadays are completely resistant for the action of presently available standard drugs [59]. The infection of TB is so common that it has caused around 1.4 million deaths and 10.4 million clinical cases all over globe as reported in 2015 [60,61].…”

Section: Synthesis Of Chlorine Bearing Anti-tuberculosis Drugsmentioning

confidence: 99%

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

Fang

Lekkala

Rakesh

et al. 2019

European Journal of Medicinal Chemistry

162

View full text Add to dashboard Cite

a b s t r a c tAt present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. This review describes the recent advances in the synthesis of chlorine containing heterocyclic compounds as diverse biological agents and drugs in the pharmaceutical industries for the inspiration of the discovery and development of more potent and effective chlorinated drugs against numerous death-causing diseases.

show abstract

Section: Synthesis Of Chlorine Bearing Anti-tuberculosis Drugsmentioning

confidence: 99%

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

Fang

Lekkala

Rakesh

et al. 2019

European Journal of Medicinal Chemistry

162

View full text Add to dashboard Cite

show abstract

“…This disease is a threat to the human life affecting lungs primarily (pulmonary TB) apart from other vital organs. Drug-resistant TB (DR-TB), multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and totally drug resistant TB (TDR) are emerging now a day's which are completely resistant for the action of presently available standard drugs [169]. The infection of TB is so high that it has caused deaths of around 1.4 million and 10.4 million clinical cases all over globe as reported in 2015 [170,171].…”

Section: Tuberculosis Activitymentioning

confidence: 99%

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

Zhao

Rakesh

Ravidar

et al. 2019

European Journal of Medicinal Chemistry

383

183

View full text Add to dashboard Cite

a b s t r a c tSulfur (S VI ) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new less toxic, low cost and highly active sulfonamides containing analogues are hot research topics in medicinal chemistry. Currently, more than 150 FDA approved Sulfur (S VI )-based drugs are available in the market, and they are widely used to treat various types of diseases with therapeutic power. This comprehensive review highlights the recent developments of sulfonyl or sulfonamides based compounds in huge range of therapeutic applications such as antimicrobial, anti-inflammatory, antiviral, anticonvulsant, antitubercular, antidiabetic, antileishmanial, carbonic anhydrase, antimalarial, anticancer and other medicinal agents. We believe that, this review article is useful to inspire new ideas for structural design and developments of less toxic and powerful Sulfur (S VI ) based drugs against the numerous death-causing diseases.

show abstract

“…Moreover, coumarins are considered as a privileged scaffold in the design of compounds with several biological targets. Coumarin derivatives displayed a wide range of pharmacological activities like anti-cancer [188], among others [189][190][191][192][193].…”

Section: Coumarin Derivativesmentioning

confidence: 99%

Synthesis of Biologically Active Molecules through Multicomponent Reactions

et al. 2020

View full text Add to dashboard Cite

Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review.Molecules 2020, 25, 505 2 of 71 acetylcholinesterase inhibitors, anti-HIV, antimicrobial, antioxidant, anti-mycobacterial and anticancer activities ( Figure 1). It is noteworthy that 64% and 16% of the supporting literature found for this review correspond to heterocyclic structures with anticancer and antimicrobial activities, respectively. Scheme 2. Three-component synthesis of 3,4-dihydropyrimidinones/thiones type 7 under microwave irradiation, for anti-inflammatory activity.Patil et al., reported a one-pot pseudo-five-component synthesis of highly functionalized tetrahydropyridines 9 using Cu(OTf) 2 as catalyst, Scheme 3. In vitro anti-inflammatory activity of the obtained compounds 9 was determined against matrix metalloproteinases (MMPs) as MMP-2 and MMP-9 by using gelatin zymography [29]. Scheme 3. Multicomponent Cu(OTf) 2 catalyzed synthesis of substituted tetrahydropyridines 9 for anti-inflammatory activity.A highly diastereoselective synthesis (exclusively the cis isomer is formed), of chromeno β-lactam hybrids 13/14 was also achieved by an efficient one-pot three-component reaction between either 5,5-dimethylcyclohexane-1,3-dione (10a) or 4-hydroxycoumarin (10b), diverse benzaldehydes 11 and malononitrile (12), in the presence of DABCO under reflux conditions (Scheme 4). Scheme 4. Three-component synthesis of β-lactam hybrids 13/14 for anti-inflammatory activity.The synthesized compounds (13 in 80-95% yield) and (14 in 82-95% yield) were screened for anti-inflammatory activity (as well as for anticancer activity, please see Section 3.13.13. Compound 13b (Ar = 4-ClC 6 H 4 , Ar 1 = 4-MeC 6 H 4 ) was the most active of all the chromeno β-lactam hybrids 13/14 tested, with a 19.8 anti-inflammatory ratio, although, it resulted less active than the reference drug dexamethasone corticosteroid used for the treatment of rheumatoid and skin inflammation [30].

show abstract

Recent developments of coumarin-containing derivatives and their anti-tubercular activity

Cited by 191 publications

References 84 publications

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

Synthesis of Biologically Active Molecules through Multicomponent Reactions

Contact Info

Product

Resources

About