Recent developments of collagen-based materials for medical applications and drug delivery systems

Rao, K. Panduranga

doi:10.1163/156856295x00526

Cited by 109 publications

(31 citation statements)

References 47 publications

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“…As a fully biodegradable, restorable, and haemostatic in nature, collagen has more advantages in wound healing over synthetic biomaterials [2,28]. With regard to the infected wound, effective wound bed preparation depends on the management of microbial balance as well as the treatment of infection.…”

Section: Discussionmentioning

confidence: 99%

Triphala Incorporated Collagen Sponge—A Smart Biomaterial for Infected Dermal Wound Healing

Muthusamy

Shanmugam

Sripriya

et al. 2010

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Triphala Incorporated Collagen Sponge—A Smart Biomaterial for Infected Dermal Wound Healing

Muthusamy

Shanmugam

Sripriya

et al. 2010

Journal of Surgical Research

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“…Collagen is a biopolymer with regenerative and tissue reconstruction properties used in various treatments in medicine [12], drugs [13] or urinary drains [14]. In addition, collagen is used as food supplements [15] and antimicrobial emulsion formulations for cosmetic purposes [16].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Properties of Nanofibres Based on Concentrated Collagen Hydrolysate Loaded with Thyme and Oregano Essential Oils

et al. 2020

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This research aimed to obtain biocompatible and antimicrobial nanofibres based on concentrated collagen hydrolysate loaded with thyme or oregano essential oils as a natural alternative to synthesis products. The essential oils were successfully incorporated using electrospinning process into collagen resulting nanofibres with diameter from 471 nm to 580 nm and porous structure. The presence of essential oils in collagen nanofibre mats was confirmed by Attenuated Total Reflectance -Fourier Transform Infrared Spectroscopy (ATR-FTIR), Ultraviolet–visible spectroscopy (UV–VIS) and antimicrobial activity. Scanning Electron Microscopy with Energy Dispersive Spectroscopy analyses allowed evaluating the morphology and constituent elements of the nanofibre networks. Microbiological tests performed against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans showed that the presence of essential oils supplemented the new collagen nanofibres with antimicrobial properties. The biocompatibility of collagen and collagen with essential oils was assessed by in vitro cultivation with NCTC clone 929 of fibroblastic cells and cell viability measurement. The results showed that the collagen and thyme or oregano oil composites have no cytotoxicity up to concentrations of 1000 μg·mL−1 and 500 μg mL−1, respectively. Optimization of electrospinning parameters has led to the obtaining of new collagen electrospun nanofibre mats loaded with essential oils with potential use for wound dressings, tissue engineering or protective clothing.

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“…Gelatin has a wide range of applications in the food, pharmaceutical, cosmetic, and photographic industries because of its unique physicochemical and technological properties. In particular, gelatin has been used as an emulsifier, foaming agent, colloid stabilizer, fining agent and biodegradable packaging material with foods (Gómez-Guilén, Giménez, López-Caballero, & Montero, 2011); as a matrix for implants, in injectable drug-delivery microspheres, and in intravenous infusions in the pharmaceutical field (Saddler & Horsey, 1987;Pollack, 1990;Rao, 1995); as an application for manufacturing hard and soft capsules, plasma expanders and in wound care (Ahmed, Ptaszek, & Basu, 2016). Additionally, gelatin is recommended for use in foodstuffs to enhance protein levels, especially in body-building food because it is low in calories.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Hue¹,

Hang²,

R.G.³

2017

Turk. J. Fish. Aquat. Sci.

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The main purpose of this study was to extract and characterize gelatin from skins of fishes: European perch (Perca fluviatilis) and Volga pikeperch (Sander volgensis), which were collected from the Volga-Caspian basin in Russia. The gelatins were prepared using an alkaline pretreatment. The gelatin yield was in the range of 10.2-13.8% on a wet weight basis, and the gel strength exceeded 184 and 193 g for samples from European perch and Volga pikeperch skins, respectively. The pH values of gelatins were 5.49 and 5.73, melting points were 24.5 and 25.5 o C and protein content was 88.6 and 91.0%, respectively. Water-holding and fat-binding capacities of gelatins were 227-235 and 439-453%, respectively. The gelatins were composed of α-chains, β-chains, and γ-chains. The apparent valine content of the two gelatins was significantly higher than those of gelatins from other fish species. The total apparent proportions of imino acids were 192 and 203 residues/1000 residues. The gelatins from European perch and Volga pikeperch skins had relatively high gel strengths, melting points, water-holding and fat-binding capacities as compared with those of other types of fish and could be recommended as potential replacements for mammalian gelatin in the food industry.

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Recent developments of collagen-based materials for medical applications and drug delivery systems

Cited by 109 publications

References 47 publications

Triphala Incorporated Collagen Sponge—A Smart Biomaterial for Infected Dermal Wound Healing

Triphala Incorporated Collagen Sponge—A Smart Biomaterial for Infected Dermal Wound Healing

Bioactive Properties of Nanofibres Based on Concentrated Collagen Hydrolysate Loaded with Thyme and Oregano Essential Oils

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