Recent developments made in the assessment of the antidiabetic potential of gymnema species - From 2016 to 2020

Synergistic antimalarial treatment of Plasmodium berghei infection in mice with dihydroartemisinin and Gymnema inodorum leaf extract

“…The many therapeutic phytochemical substances discovered in the leaves of G. inodorum include phenolics, flavonoids, terpenoids, triterpenoid saponin, and glycosides. These have been shown to have antioxidant, anti-inflammatory, anti-diabetic, anti-hypoglycemic, anti-adipogenesis, anti-microbial, and anti-cancerous properties [ 8 ]. Previous studies of G. inodorum leaf extract using in vivo models have found this plant to exhibit potent antimalarial activity and protection against hypoglycemia, dyslipidemia, liver damage, and acute kidney injury, with normalization of hematological parameters that have been dysregulated by Plasmodium berghei infection in mice [ 9 – 11 ].…”

Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus

“…Therefore, the identification of novel functional Asian foods regulating blood glucose levels has emerged as an important project of research in T2DM (Brand-Miller et al 2012;Gunnerud et al 2012;Shishehbor et al 2017). Many natural products such as Asian apricots and their processed foods have been taken as daily foods and folk medicine in many Asian countries including Japan and also widely consumed throughout the world because of their possible health benefits (Hao da and Xiao 2014; Wu et al 2018;Aoi et al 2020;Aoi et al 2021;Chakraborty and Roy 2021;Georgiev et al 2021;Rambaran and Nordström 2021;Kahksha et al 2022;Ma et al 2022;Pan et al 2022;Zahedipour et al 2022;Zhu et al 2022). However, we have little information on the molecular mechanisms how the natural products show their health benefits.…”

Triterpenoid saponins and C21 steroidal glycosides from Gymnema tingens and their glucose uptake activities

“…22–27 In traditional herbal medicine, the Gymnema species has been well known for the anti-diabetic potential. 28…”