Recent developments in thyroid eye disease

Cawood, Tom; Moriarty, Paul; O’Shea, Donal

doi:10.1136/bmj.329.7462.385

Cited by 63 publications

(31 citation statements)

References 27 publications

(18 reference statements)

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“…In fact, the HRQOL has been studied principally in the setting of orbitopathy [11,12], where it seems that a worsening HRQOL is related to the grade of ophthalmopathy [12]. However, no studies have so far focused on the impact of surgery on the subsequent HRQOL in GD patients.…”

Section: Introductionmentioning

confidence: 99%

Does thyroid surgery for Graves’ disease improve health-related quality of life?

et al. 2012

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Purpose Graves' disease can induce alterations of the psychosocial well-being that negatively influence the overall well-being of patients. Among the current treatments, surgery has limited indications, and its impact on the health-related quality of life has not been well clarified. The aim of this study was to assess the impact of surgery on the quality of life. Methods Fifty-seven patients who underwent total thyroidectomy for Graves' disease in our surgical unit between April 2002 and December 2009 were administered a questionnaire concerning four issues: organic alterations and clinical manifestations, neurovegetative system disturbances, impairment of daily activities, psychosocial problems. Patients were retrospectively questioned after thyroidectomy about the presence of these symptoms in both the pre and postoperative periods. Results There was a significant improvement after surgery in all four areas. Organic manifestations and psychosocial problems had higher average improvements, as did some aspects of the neurovegetative system and difficulties in undertaking daily activities. There were no reports of a worsening of symptoms. Conclusions Surgery resolved the hyperthyroidism in 100 % of cases, and was associated with a quality of life improvement of about 70 % in the patients. Surgery can therefore provide an immediate and effective resolution of Graves' disease, with benefits in health-related quality of life.

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Section: Introductionmentioning

confidence: 99%

Does thyroid surgery for Graves’ disease improve health-related quality of life?

et al. 2012

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“…Genetic susceptibility and endogenous and environmental factors play a role in its development. [2][3][4] The genetic factors are poorly defined but appear to have the lesser role. 2 The risk of developing TED increases with age and women are more likely to develop Graves' disease than men.…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking and thyroid eye disease: a systematic review

Kelly

et al. 2006

Eye

169

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“…A reported UK prevalence of thyrotoxicosis is 2.2%, 14 of which nearly two-thirds is autoimmuneFthat is, 1.4% prevalence. There have been various and changing reported incidences for overt ophthalmopathy in patients with autoimmune thyroid disease, 15 but a recent UK estimate is about 30% 16 Fgiving a UK population estimated prevalence of about 0.4% (30% of 1.4%); at this prevalence, there should have been no more than two cases of orbitopathy among our 369 lymphoma patients. The observed prevalence of at least 6/369 (1.63%) patients with thyroid ophthalmopathy in our series is, therefore, highly unlikely to have occurred by chance (P ¼ 0.007).…”

Section: Discussionmentioning

confidence: 96%