2004
DOI: 10.1136/bmj.329.7462.385
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Recent developments in thyroid eye disease

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Cited by 63 publications
(31 citation statements)
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“…In fact, the HRQOL has been studied principally in the setting of orbitopathy [11,12], where it seems that a worsening HRQOL is related to the grade of ophthalmopathy [12]. However, no studies have so far focused on the impact of surgery on the subsequent HRQOL in GD patients.…”
Section: Introductionmentioning
confidence: 99%
“…In fact, the HRQOL has been studied principally in the setting of orbitopathy [11,12], where it seems that a worsening HRQOL is related to the grade of ophthalmopathy [12]. However, no studies have so far focused on the impact of surgery on the subsequent HRQOL in GD patients.…”
Section: Introductionmentioning
confidence: 99%
“…Genetic susceptibility and endogenous and environmental factors play a role in its development. [2][3][4] The genetic factors are poorly defined but appear to have the lesser role. 2 The risk of developing TED increases with age and women are more likely to develop Graves' disease than men.…”
Section: Introductionmentioning
confidence: 99%
“…A reported UK prevalence of thyrotoxicosis is 2.2%, 14 of which nearly two-thirds is autoimmuneFthat is, 1.4% prevalence. There have been various and changing reported incidences for overt ophthalmopathy in patients with autoimmune thyroid disease, 15 but a recent UK estimate is about 30% 16 Fgiving a UK population estimated prevalence of about 0.4% (30% of 1.4%); at this prevalence, there should have been no more than two cases of orbitopathy among our 369 lymphoma patients. The observed prevalence of at least 6/369 (1.63%) patients with thyroid ophthalmopathy in our series is, therefore, highly unlikely to have occurred by chance (P ¼ 0.007).…”
Section: Discussionmentioning
confidence: 96%