Recent Developments in the Chemistry of Pyrido[1,2-a]pyrimidines

Synthesis, characterization, and antimicrobial evaluation of novel 4‐pyrrol‐1‐yl‐5,6,7,8‐tetrahydro‐pyrido[4′,3′:4,5] thieno[2,3‐d]pyrimidine derivatives

“…1 H NMR spectra were recorded on a Varian 400 spectrometer in DMSO-d 6 as a solvent and TMS as an internal standard. Peak values are shown in d ppm.…”

“…This is evident, in particular, from publications of regular reviews on the chemistry of systems where the pyrimidine ring is fused to various heterocycles, such as, purines [1], pteridines [2], quinazolines [3], pyridopyrimidines [4,5], triazolopyrimidines [6], pyrazolopyrimidines [7], pyrimidoazepines [8], furopyrimidines, and pyrrolopyrimidines. Thienopyrimidines occupy a special position among these compounds.…”

N-bridged heterocycles: regiospecific synthesis of 2-methyl-4H-pyrimido[2,1-b]benzothiazol-4-ones

“…The N-bridged heterocycles containing nitrogen atom common to two rings, particularly fused heterosystems, have been the subject of great concern in the chemical research not only from the theoretical point of view, but also for the preparation of potential pharmaceuticals [1][2][3][4][5][6][7][8][9][10]. In view of the structural diversity and pharmacological significance of N-bridged heterocycles resulting in the fusion of two biodynamic heterosystems and our continuing efforts of synthesizing especially nitrogen-and sulfur-containing heterocycles of potential therapeutic interest [11][12][13], we have synthesized novel bioactive heterocycles, 2-methyl-4H-pyrimido [2,1-b]benzothiazol-4-ones, which involve the structural fusion of two structurally as well pharmacologically interesting heterocyclic systems [14][15][16]; benzothiazole and pyrimidine.…”